Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

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Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/CB4005063
P932PMC publication ID3833349
P698PubMed publication ID24015914
P5875ResearchGate publication ID256478272

P50authorGunter SchneiderQ1554915
James Henderson NaismithQ17507299
Robert SchnellQ84817083
Ylva LindqvistQ28324830
David W. GrayQ55175940
Lucile MoyniéQ60678342
P2093author name stringMahavir Singh
Ayssar A Elamin
Anthony G Hope
Holger Kneuper
Susanne Schach
Cyprian D Cukier
P2860cites workPseudomonas Genome Database: improved comparative analysis and population genomics capability for Pseudomonas genomesQ24609340
Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymesQ24642281
Structure-based virtual screening for drug discovery: a problem-centric reviewQ27022502
Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basisQ27635477
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesisQ27639230
Crystal structure of a 3-oxoacyl-(acylcarrier protein) reductase (BA3989) from Bacillus anthracis at 2.4-A resolutionQ27648489
Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolutionQ27673602
The AEROPATH project targetingPseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discoveryQ27675787
Crystal structure and fluorescence studies reveal the role of helical dimeric interface of staphylococcal FabG1 in positive cooperativity for NADPHQ27676871
Crystal structure of hexanoyl-CoA bound to β-ketoacyl reductase FabG4 of Mycobacterium tuberculosisQ27683485
Structural insights into the mechanism and inhibition of the β-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonas aeruginosaQ27683498
Pseudomonas aeruginosa: all roads lead to resistanceQ28240246
Integration-proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strainsQ73301855
Finding the sweet spot: the role of nature and nurture in medicinal chemistryQ84032484
Prediction and analysis of the protein interactome in Pseudomonas aeruginosa to enable network-based drug target selectionQ28481505
Isolation and characterization of beta-ketoacyl-acyl carrier protein reductase (fabG) mutants of Escherichia coli and Salmonella enterica serovar TyphimuriumQ28563574
A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutantsQ29547327
Ligand efficiency: a useful metric for lead selectionQ29617403
NMR spectroscopy techniques for screening and identifying ligand binding to protein receptorsQ30887851
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoidsQ33244527
Lessons learnt from assembling screening libraries for drug discovery for neglected diseasesQ33309109
Bacterial fatty acid biosynthesis: targets for antibacterial drug discoveryQ34090225
The antibacterial efficacy of an aceraceous plant [Shantung maple (Acer truncatum Bunge)] may be related to inhibition of bacterial beta-oxoacyl-acyl carrier protein reductase (FabG).Q34587342
Forty years of bacterial fatty acid synthesisQ34610848
Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomesQ34766191
Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?Q35350186
Fatty acid biosynthesis as a target for novel antibacterialsQ35713880
Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabGQ35879195
The reductase steps of the type II fatty acid synthase as antimicrobial targetsQ36052456
Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.Q36724203
Fatty acid synthesis in protozoan parasites: unusual pathways and novel drug targets.Q37160877
In vitro precursor-directed synthesis of polyketide analogues with coenzyme a regeneration for the development of antiangiogenic agentsQ37350442
Pseudomonas aeruginosa - a phenomenon of bacterial resistanceQ37520253
Pseudomonas aeruginosa: a formidable and ever-present adversaryQ37584596
Current understanding of fatty acid biosynthesis and the acyl carrier proteinQ37775996
Recent developments for Pseudomonas vaccinesQ37937369
Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.Q37979307
Novel therapeutic strategies to counter Pseudomonas aeruginosa infections.Q37984505
Design, synthesis, and evaluation of pharmacological properties of cinnamic derivatives as antiatherogenic agents.Q40338190
Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesisQ42095354
Macrolactin S, a new antibacterial agent with FabG-inhibitory activity from Bacillus sp. AT28.Q44616531
Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG.Q44796688
Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthaseQ44888115
Know your chemical spaceQ57932475
P433issue11
P921main subjectPseudomonas aeruginosaQ31856
allosteric inhibitorQ70361704
P304page(s)2518-2527
P577publication date2013-09-23
P1433published inACS Chemical BiologyQ165583
P1476titleDiscovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa
P478volume8

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cites work (P2860)
Q35839906A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA
Q55311481Advance in Research on Mycobacterium tuberculosis FabG4 and Its Inhibitor.
Q91594249An integrated genomic regulatory network of virulence-related transcriptional factors in Pseudomonas aeruginosa
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Q30278363Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae
Q38264138Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering
Q39309646Stabilization of Multimeric Proteins via Intersubunit Cyclization.
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Q55316125Tachyplesin Causes Membrane Instability That Kills Multidrug-Resistant Bacteria by Inhibiting the 3-Ketoacyl Carrier Protein Reductase FabG.
Q28080940Using modern tools to probe the structure-function relationship of fatty acid synthases
Q61446735Validation of the anti-infective potential of a polyherbal 'Panchvalkal' preparation, and elucidation of the molecular basis underlining its efficacy against Pseudomonas aeruginosa

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