Lessons learnt from assembling screening libraries for drug discovery for neglected diseases

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Lessons learnt from assembling screening libraries for drug discovery for neglected diseases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CMDC.200700139
P932PMC publication ID2628535
P698PubMed publication ID18064617
P5875ResearchGate publication ID5782923

P50authorIan H. GilbertQ38322743
Paul G. WyattQ41782047
Ruth BrenkQ50638394
P2093author name stringDaniel James
Alessandro Schipani
Julie Frearson
Agata Krasowski
P2860cites workHit and lead generation: beyond high-throughput screeningQ28204526
Drug development for neglected diseases: a deficient market and a public-health policy failureQ28207953
Molecular similarity analysis in virtual screening: foundations, limitations and novel approachesQ28290933
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsQ28842973
The art and practice of structure-based drug design: A molecular modeling perspectiveQ29029768
Drugs for bad bugs: confronting the challenges of antibacterial discoveryQ29547723
Protein kinases--the major drug targets of the twenty-first century?Q29615339
Can the pharmaceutical industry reduce attrition rates?Q29616077
Opportunities and Challenges in Antiparasitic Drug DiscoveryQ29999214
Pursuing the leadlikeness concept in pharmaceutical research.Q30832332
A novel approach to combinatorial library designQ30833119
Property distribution of drug-related chemical databases.Q30855791
Molecular complexity and its impact on the probability of finding leads for drug discoveryQ30993107
Is there a difference between leads and drugs? A historical perspectiveQ31017131
A fresh look at pharmaceutical screening library designQ31154316
A new approach to finding natural chemical structure classesQ33185162
Drug-like annotation and duplicate analysis of a 23-supplier chemical database totalling 2.7 million compoundsQ33199870
"In-house likeness": comparison of large compound collections using artificial neural networksQ33220365
Recent developments in focused library design: targeting gene-familiesQ33232966
Relationships between Molecular Complexity, Biological Activity, and Structural DiversityQ33237552
An empirical process for the design of high-throughput screening deck filters.Q33244050
Virtual ligand screening: strategies, perspectives and limitationsQ33247681
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screeningQ33267859
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activityQ33267962
A high-throughput screening approach to anthrax lethal factor inhibitionQ33275326
Identifying druglike inhibitors of myelin-reactive T cells by phenotypic high-throughput screening of a small-molecule libraryQ33283649
On sampling of fragment spaceQ33287567
A ‘Rule of Three’ for fragment-based lead discovery?Q33973131
In silico approaches to prediction of aqueous and DMSO solubility of drug-like compounds: trends, problems and solutionsQ34493552
Protein kinases as drug targets in trypanosomes and LeishmaniaQ34578463
Two decades of orphan product developmentQ34932215
Integration of virtual and high-throughput screeningQ34988235
Designing screens: how to make your hits a hit.Q35096198
Targeting metabolic pathways in microbial pathogens: oxidative stress and anti-folate drug resistance in trypanosomatidsQ35139370
A journey of hope: lessons learned from studies on rare diseases and orphan drugsQ36514274
Innovative lead discovery strategies for tropical diseasesQ36642049
Drug discovery and development for neglected parasitic diseasesQ36654913
Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitorsQ36723753
A decade of fragment-based drug design: strategic advances and lessons learnedQ36732253
How many leads from HTS?Q56627226
Strategic Pooling of Compounds for High-Throughput ScreeningQ56854153
Patent senseQ60099865
Database diversity assessment: new ideas, concepts, and toolsQ73913472
Virtual exploration of the small-molecule chemical universe below 160 DaltonsQ81327462
Virtual Exploration of the Small-Molecule Chemical Universe below 160 DaltonsQ99234037
P433issue3
P921main subjectdrug discoveryQ1418791
drug screeningQ10505555
P304page(s)435-444
P577publication date2008-03-01
P1433published inChemMedChemQ2962252
P1476titleLessons learnt from assembling screening libraries for drug discovery for neglected diseases
P478volume3

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