Screening-based discovery ofAspergillus fumigatusplant-type chitinase inhibitors

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Screening-based discovery ofAspergillus fumigatusplant-type chitinase inhibitors is …
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scholarly articleQ13442814

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P356DOI10.1016/J.FEBSLET.2014.07.015
P932PMC publication ID4158421
P698PubMed publication ID25063338
P5875ResearchGate publication ID264246939

P50authorDaan van AaltenQ58833300
P2093author name stringDavid E Blair
Deborah E A Lockhart
Alexander Schuettelkopf
P2860cites workAspergillus fumigatus: cell wall polysaccharides, their biosynthesis and organizationQ37506518
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From bacteria to human: a journey into the world of chitinasesQ38149651
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Extracellular DNA release acts as an antifungal resistance mechanism in mature Aspergillus fumigatus biofilms.Q39932219
An extracellular matrix glues together the aerial-grown hyphae of Aspergillus fumigatusQ40232088
Search for microbial insect growth regulators. II. Allosamidin, a novel insect chitinase inhibitorQ42074935
Disruption of the gene encoding the ChiB1 chitinase of Aspergillus fumigatus and characterization of a recombinant gene productQ44605345
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.Q45233933
Molecular cloning of a third chitinase gene (CHT1) from Candida albicansQ48065166
Kinetic characterization of recombinant human acidic mammalian chitinase.Q50335605
Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor.Q51937592
A Multistep Voriconazole-Related Phototoxic Pathway May Lead to Skin Carcinoma: Results From a French Nationwide StudyQ57779700
Functional analysis of the fungal/plant class chitinase family in Aspergillus fumigatusQ61485319
In vivo biofilm composition of Aspergillus fumigatusQ84846877
Search for microbial insect growth regulators. II Allosamidin, a novel insect chitinase inhibitor.Q104396031
A classification of glycosyl hydrolases based on amino acid sequence similaritiesQ24527325
High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: mimicry of carbohydrate substrateQ27639303
Crystal structures of allosamidin derivatives in complex with human macrophage chitinaseQ27640707
Structure of Saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitorsQ27644927
Acetazolamide-based fungal chitinase inhibitorsQ27665555
Natural Product–Guided Discovery of a Fungal Chitinase InhibitorQ27666337
Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like InhibitorQ27667980
Discovery of a Novel Class of Orally Active Trypanocidal N -Myristoyltransferase InhibitorsQ27676019
REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its useQ27860632
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Features and development of CootQ27861079
Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteinsQ28118880
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysQ28145712
Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteriaQ28295337
Hidden killers: human fungal infectionsQ29617101
Reporting data from high-throughput screening of small-molecule librariesQ31119136
Aspergillosis case-fatality rate: systematic review of the literatureQ31918085
Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.Q33223926
Lessons learnt from assembling screening libraries for drug discovery for neglected diseasesQ33309109
Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinasesQ33598650
Are we there yet? Recent progress in the molecular diagnosis and novel antifungal targeting of Aspergillus fumigatus and invasive aspergillosisQ35034171
Chitin synthesis as target for antifungal drugsQ35061083
Long-term antifungal treatment improves health status in patients with chronic pulmonary aspergillosis: a longitudinal analysisQ37111641
The changing face of epidemiology of invasive fungal disease in EuropeQ37458702
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectbiophysicsQ7100
cell biologyQ7141
structural biologyQ908902
P1104number of pages9
P304page(s)3282-3290
P577publication date2014-07-22
P1433published inFEBS LettersQ1388051
P1476titleScreening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors
P478volume588

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Q37562147The Mechanistic Targets of Antifungal Agents: An Overviewcites workP2860

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