Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

scientific article published in January 2019

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0217828
P932PMC publication ID6544269
P698PubMed publication ID31150492
P4011Semantic Scholar paper IDb9f0651df2c3c650af36cdb3f5c2861719c66e90

P50authorFabio ZuccottoQ55175938
David W. GrayQ55175940
Manu De RyckerQ56872400
Leah S TorrieQ88131715
Ian H. GilbertQ38322743
David A RobinsonQ39769935
P2860cites workThe CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1BQ22010528
Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruziQ24815881
Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein PhosphorylationQ27654063
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsQ27861111
The unconventional kinetoplastid kinetochore: from discovery toward functional understandingQ28071855
Biochemical characterization and localization of the dual specificity kinase CLK1Q28144343
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysQ28145712
Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screenQ28538804
Recent Development of Visceral Leishmaniasis Treatments: Successes, Pitfalls, and PerspectivesQ57166879
Chagas diseaseQ58842312
Human African trypanosomiasisQ58842320
Challenges and recent progress in drug discovery for tropical diseasesQ59073293
Kinetic mechanism of the p38-alpha MAP kinase: phosphoryl transfer to synthetic peptidesQ73469218
The kinetochore-microtubule interface at a glanceQ90987690
LeishmaniasisQ91045453
Protein kinases: evolution of dynamic regulatory proteinsQ30014836
Mechanism of activation of ERK2 by dual phosphorylationQ31443949
Lessons learnt from assembling screening libraries for drug discovery for neglected diseasesQ33309109
The kinetochoreQ33796368
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosomeQ33833378
High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma bruceiQ33930895
From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead moleculesQ34775438
Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomesQ35516152
OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and ProteinsQ35846188
Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein KinasesQ36294025
Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected].Q36998826
Through the "gatekeeper door": exploiting the active kinase conformationQ37650047
Discovery of unconventional kinetochores in kinetoplastids.Q37690124
Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.Q38948559
Divergent polo box domains underpin the unique kinetoplastid kinetochoreQ39879158
The properties of known drugs. 1. Molecular frameworksQ40933327
Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics.Q41582222
A dynamic hydrophobic core orchestrates allostery in protein kinases.Q42292504
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma bruceiQ33244
P304page(s)e0217828
P577publication date2019-05-31
P1433published inPLOS OneQ564954
P1476titleIdentification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase
P478volume14

Reverse relations

cites work (P2860)
Q90407108Characterization of unconventional kinetochore kinases KKT10/19 in Trypanosoma brucei
Q97530013Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

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