Screening a protein kinase inhibitor library against Plasmodium falciparum

scientific article published on 7 November 2017

Screening a protein kinase inhibitor library against Plasmodium falciparum is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1092576388
P356DOI10.1186/S12936-017-2085-4
P2888exact matchhttps://scigraph.springernature.com/pub.10.1186/s12936-017-2085-4
P932PMC publication ID5678585
P698PubMed publication ID29115999

P50authorAlan FairlambQ4706598
Ian H. GilbertQ38322743
Paul G. WyattQ41782047
Beatriz BaragañaQ55175935
Irene HallyburtonQ114415548
Julie A FrearsonQ114415586
Torsten LukschQ114533529
Daniel SpinksQ117274704
P2093author name stringDaniel James
David Waterson
Didier Leroy
Andrew Woodland
Raffaella Grimaldi
P2860cites workThe protein kinase complement of the human genomeQ24324497
Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryoteQ24792290
Targeting Plasmodium PI(4)K to eliminate malariaQ27974482
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasitesQ28480979
A novel multiple-stage antimalarial agent that inhibits protein synthesisQ30044020
Drug resistance in eukaryotic microorganismsQ30248243
Protein kinases as targets for anti-parasitic chemotherapyQ30828981
Lessons learnt from assembling screening libraries for drug discovery for neglected diseasesQ33309109
Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488Q33990598
Malaria biology and disease pathogenesis: insights for new treatmentsQ34579700
Current kinase inhibitors cover a tiny fraction of fragment space.Q35614315
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screenQ36736936
Trisubstituted Pyrimidines as Efficacious and Fast-Acting AntimalarialsQ37101499
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo EfficacyQ37412029
The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?Q37591585
Exploring novel targets for antimalarial drug discovery: plasmodial protein kinasesQ37718296
A medicinal chemist's guide to molecular interactionsQ37719514
The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring typesQ37815587
Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticityQ37894319
Plasmodium kinases as targets for new-generation antimalarialsQ38066993
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.Q39337756
Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinicQ40106428
Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.Q40815932
Characteristics of a human diploid cell designated MRC-5.Q43462188
The influence of drug-like concepts on decision-making in medicinal chemistryQ46922861
Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparumQ47996321
A genomic perspective of protein kinases in Plasmodium falciparumQ56558814
Plasmodium falciparum: Assessment of in vitro growth by [3H]hypoxanthine incorporationQ70238538
P433issue1
P921main subjectPlasmodium falciparumQ311383
P304page(s)446
P577publication date2017-11-07
P1433published inMalaria JournalQ15749954
P1476titleScreening a protein kinase inhibitor library against Plasmodium falciparum
P478volume16

Reverse relations

cites work (P2860)
Q64064607High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites
Q90914855Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease
Q91871690Who Needs a Contractile Actomyosin Ring? The Plethora of Alternative Ways to Divide a Protozoan Parasite

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