Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site

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Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site is …
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scholarly articleQ13442814

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P819ADS bibcode2014NatCo...5.3037C
P6179Dimensions Publication ID1007507073
P356DOI10.1038/NCOMMS4037
P3181OpenCitations bibliographic resource ID3797889
P932PMC publication ID4082030
P698PubMed publication ID24390130

P2093author name stringChunyu Wang
David J Rosenman
Wen Chen
Yue-Ming Li
Jian Xie
Maria M Lopez
Eric Gamache
P2860cites workThe mechanism of γ-Secretase dysfunction in familial Alzheimer diseaseQ36000134
Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neuronsQ36324215
Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's diseaseQ36459592
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?Q36948254
A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysisQ37083598
Transmembrane structures of amyloid precursor protein dimer predicted by replica-exchange molecular dynamics simulationsQ37307178
Expression, purification, and reconstitution of the transmembrane domain of the human amyloid precursor protein for NMR studiesQ39708958
Mutations in APP have independent effects on Abeta and CTFgamma generationQ40506128
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifsQ41822677
Shifting a complex debate on γ-secretase cleavage and Alzheimer's diseaseQ41828981
Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.Q43697159
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogsQ46028454
The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulatorsQ46772118
Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD productionQ47880180
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.Q51776761
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.Q53207278
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).Q53214445
A simple apparatus for generating stretched polyacrylamide gels, yielding uniform alignment of proteins and detergent micellesQ77587741
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACEQ22010705
Purification and cloning of amyloid precursor protein beta-secretase from human brainQ22010914
Purification and characterization of the human gamma-secretase complexQ24300026
Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environmentQ24321998
The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds CholesterolQ27679405
A transmembrane helix dimer: structure and implicationsQ27735013
Automated NMR structure calculation with CYANAQ27860754
The Xplor-NIH NMR molecular structure determination packageQ27860805
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
Evaluating protein structures determined by structural genomics consortiaQ29547577
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's diseaseQ29614374
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formationQ29616564
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.Q30336360
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's diseaseQ30955688
Liquid crystalline phase of G-tetrad DNA for NMR study of detergent-solubilized proteinsQ31156343
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.Q33276402
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutantsQ33317424
Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motifQ33572654
A cell biological perspective on Alzheimer's diseaseQ34141335
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.Q34148927
Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor proteinQ34535890
{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.Q34635580
Gamma-secretase-mediated proteolysis in cell-surface-receptor signallingQ34810184
Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease.Q34856213
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor proteinQ35065215
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)3037
P577publication date2014-01-01
P1433published inNature CommunicationsQ573880
P1476titleFamilial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site
P478volume5

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cites work (P2860)
Q27011749Alzheimer's disease--a panorama glimpse
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Q90661748Helix-Switch Enables C99 Dimer Transition between the Multiple Conformations
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