Mutations in APP have independent effects on Abeta and CTFgamma generation

scientific article

Mutations in APP have independent effects on Abeta and CTFgamma generation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.NBD.2004.04.018
P698PubMed publication ID15474359
P5875ResearchGate publication ID8242204

P50authorAlison GoateQ45660395
Silva HecimovicQ56832004
P2093author name stringJun Wang
Georgia Dolios
Rong Wang
Maribel Martinez
P2860cites workMembrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activityQ22010912
Purification and cloning of amyloid precursor protein beta-secretase from human brainQ22010914
P433issue2
P304page(s)205-218
P577publication date2004-11-01
P1433published inNeurobiology of DiseaseQ15716606
P1476titleMutations in APP have independent effects on Abeta and CTFgamma generation
P478volume17

Reverse relations

cites work (P2860)
Q37081815A TAG on to the neurogenic functions of APP
Q37083598A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis
Q37678589A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman
Q34683369A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase
Q40387366APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation
Q42674921APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1.
Q60313667Alzheimer's disease
Q37195665Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio
Q36380671Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.
Q37389332Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.
Q40077211Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages
Q31088092Amyloid-β metabolism in Niemann-Pick C disease models and patients
Q43198294An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production
Q92596034Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors
Q34555722Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation
Q33785336Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts
Q56769946Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation
Q38101383Development and mechanism of γ-secretase modulators for Alzheimer's disease
Q30512265Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease
Q51808780Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.
Q51052529Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheim
Q27681185Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site
Q40377263Identification of putative SNPs in progressive retinal atrophy affected Canis lupus familiaris using exome sequencing
Q37431194Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production
Q40183194Insulysin cleaves the APP cytoplasmic fragment at multiple sites.
Q35246412Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease
Q35768842Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.
Q35562694Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane re
Q41843325Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long
Q33515793Modulation of gamma-secretase specificity using small molecule allosteric inhibitors
Q38001784Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
Q34352043Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates
Q41899989Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway
Q38248506Pregnane X Receptor and P-glycoprotein: a connexion for Alzheimer's disease management
Q36109130Presenilin function and gamma-secretase activity
Q36481949Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease
Q28817811Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection
Q34110227Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process
Q39912930S-palmitoylation of gamma-secretase subunits nicastrin and APH-1
Q41126914Stable insertion of Alzheimer Abeta peptide into the ER membrane strongly correlates with its length
Q52620416The genes associated with early-onset Alzheimer's disease.
Q37961985The physiology of the β-amyloid precursor protein intracellular domain AICD.

Search more.