| scholarly article | Q13442814 |
| P50 | author | Shohei Koide | Q42628149 |
| P2093 | author name string | Georgia Dolios | |
| Rong Wang | |||
| Akiko Koide | |||
| Xianzhong Wu | |||
| Marcin Paduch | |||
| Steven L Wagner | |||
| Sangram S Sisodia | |||
| Phuong Nguyen | |||
| Xulun Zhang | |||
| Yueming Li | |||
| Robert Hoey | |||
| P2860 | cites work | Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease | Q24298408 |
| Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity | Q39978729 | ||
| Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2. | Q40360520 | ||
| Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. | Q40472890 | ||
| A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1. | Q40493609 | ||
| Mutations in APP have independent effects on Abeta and CTFgamma generation | Q40506128 | ||
| The role of presenilin cofactors in the gamma-secretase complex | Q40661006 | ||
| Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch | Q40718061 | ||
| Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. | Q40812654 | ||
| Single chain Fab (scFab) fragment | Q41982040 | ||
| gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation | Q44313369 | ||
| Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates | Q44488079 | ||
| Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin | Q44511126 | ||
| Nicastrin functions as a gamma-secretase-substrate receptor | Q46646587 | ||
| Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. | Q51808780 | ||
| Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. | Q53341822 | ||
| The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation | Q73396476 | ||
| Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch | Q24307727 | ||
| Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo | Q24315707 | ||
| Toward the structure of presenilin/γ-secretase and presenilin homologs | Q27002018 | ||
| T cell receptor-like recognition of tumor in vivo by synthetic antibody fragment | Q27322455 | ||
| Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1 | Q28139001 | ||
| A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain | Q28141707 | ||
| A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid | Q28207898 | ||
| Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex | Q28252335 | ||
| Trafficking and proteolytic processing of APP | Q28265871 | ||
| Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain | Q28273268 | ||
| Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line | Q29616392 | ||
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
| Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains | Q30728721 | ||
| Analysis of proteins and peptides directly from biological fluids by immunoprecipitation/mass spectrometry | Q30906375 | ||
| Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease | Q33687945 | ||
| Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. | Q33759792 | ||
| Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate | Q34014078 | ||
| Notch signaling: the core pathway and its posttranslational regulation | Q34017623 | ||
| Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production | Q34030951 | ||
| The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage | Q34173117 | ||
| Crystal structure of the γ-secretase component nicastrin | Q34218060 | ||
| Activation and intrinsic γ-secretase activity of presenilin 1 | Q34410897 | ||
| Turnover of amyloid precursor protein family members determines their nuclear signaling capability | Q34854001 | ||
| Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy | Q35065205 | ||
| Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch | Q35754149 | ||
| Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies | Q36001311 | ||
| Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex | Q36381474 | ||
| The Notch signaling pathway as a mediator of tumor survival | Q36971953 | ||
| Structure and function of gamma-secretase | Q37325174 | ||
| Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. | Q37459837 | ||
| The many substrates of presenilin/γ-secretase | Q37845036 | ||
| Development and mechanism of γ-secretase modulators for Alzheimer's disease | Q38101383 | ||
| Biological and clinical implications of nicastrin expression in invasive breast cancer | Q39728646 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| ImageQuant | Q112270642 | ||
| P433 | issue | 50 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 11 | |
| P304 | page(s) | 34851-34861 | |
| P577 | publication date | 2014-10-28 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase | |
| P478 | volume | 289 |
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