| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.275.5.3173 |
| P698 | PubMed publication ID | 10652302 |
| P2093 | author name string | D J Selkoe | |
| W Xia | |||
| M S Wolfe | |||
| W T Kimberly | |||
| T Rahmati | |||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 3173-3178 | |
| P577 | publication date | 2000-02-01 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation | |
| P478 | volume | 275 |
| Q40851871 | A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells |
| Q40841627 | A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques |
| Q34683369 | A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase |
| Q36674481 | A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? |
| Q33337950 | APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease |
| Q34014078 | Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate |
| Q34651971 | Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease |
| Q74241797 | Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1 |
| Q48239128 | Alzheimer's disease proteins in cerebellar and hippocampal synapses during postnatal development and aging of the rat. |
| Q31057900 | Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes |
| Q36271097 | Alzheimer's disease: A hypothesis on pathogenesis |
| Q33765040 | Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol |
| Q38006665 | Amyloid and Alzheimer's disease: inside and out. |
| Q34566551 | Amyloid metabolism and secretases in Alzheimer's disease |
| Q30657683 | Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes |
| Q35125093 | Aspartic proteases involved in Alzheimer's disease |
| Q24336570 | BACE (beta-secretase) modulates the processing of APLP2 in vivo |
| Q37346926 | Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters |
| Q44814697 | Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation. |
| Q40616061 | Cell-based assay for β-secretase activity |
| Q34286933 | Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease |
| Q51843477 | Continuing strategies for inhibiting Alzheimer's gamma-secretase. |
| Q54965535 | Data on solubilization, identification, and thermal stability of human Presenilin-2. |
| Q34826547 | Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease |
| Q30987095 | Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex |
| Q24306785 | Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 |
| Q40676340 | Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes |
| Q33852318 | Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases |
| Q35575845 | Distinct presenilin‐dependent and presenilin‐independent γ‐secretases are responsible for total cellular Aβ production |
| Q34966217 | ER calcium and Alzheimer's disease: in a state of flux |
| Q40674796 | Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation |
| Q34158282 | Enzymic properties of recombinant BACE2. |
| Q28211750 | Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates |
| Q37785197 | Gamma-secretase and the intramembrane proteolysis of Notch |
| Q37394529 | Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain. |
| Q33809866 | Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana |
| Q40845419 | Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases |
| Q49093504 | Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic Mice |
| Q35575841 | Identity and function of γ‐secretase |
| Q33978840 | Implications of non-canonical G-protein signaling for the immune system |
| Q34185772 | Intramembrane proteolysis by presenilins |
| Q92932113 | Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase |
| Q92265666 | Membrane receptor activation mechanisms and transmembrane peptide tools to elucidate them |
| Q34509775 | Metabolism of presenilins |
| Q26865358 | Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention |
| Q35941365 | Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved |
| Q47155049 | Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease |
| Q73695319 | Neurodegeneration: diseases of the cytoskeleton? |
| Q34180114 | Neurotoxic traffic: uncovering the mechanics of amyloid production in Alzheimer's disease |
| Q34262805 | New approaches to diagnose and treat Alzheimer's disease: a glimpse of the future |
| Q33840662 | Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration |
| Q24292718 | PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein |
| Q30439489 | Pathogenesis of Alzheimer's disease |
| Q36432181 | Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment |
| Q43749044 | Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology |
| Q44483354 | Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model |
| Q51837859 | Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein |
| Q40630606 | Presenilin 1 is involved in maturation and trafficking of N‐cadherin to the plasma membrane |
| Q24530721 | Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation |
| Q35204147 | Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation |
| Q35172682 | Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex |
| Q33944227 | Presenilin, Notch, and the genesis and treatment of Alzheimer's disease |
| Q41889633 | Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane |
| Q42162160 | Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes |
| Q34030951 | Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production |
| Q28568133 | Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane |
| Q33930862 | Presenilin-dependent gamma-secretase activity modulates thymocyte development |
| Q73133100 | Presenilin-mediated modulation of capacitative calcium entry |
| Q28817811 | Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection |
| Q73949956 | Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1 |
| Q44529190 | Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin |
| Q30811532 | Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides |
| Q30494468 | Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway |
| Q44488079 | Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates |
| Q40529866 | Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor |
| Q39372364 | Sequential proteolytic processing of an interferon-alpha receptor subunit by TNF-alpha converting enzyme and presenilins |
| Q47673255 | Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing. |
| Q28363447 | Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease |
| Q92739032 | Structure and Function of the γ-Secretase Complex |
| Q33905871 | The Alzheimer's disease mitochondrial cascade hypothesis |
| Q54107587 | The Presenilin loop region is essential for Glycogen synthase kinase 3 beta mediated functions on motor proteins during axonal transport. |
| Q34014324 | The aging process: where are the drug opportunities? |
| Q34079605 | The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins |
| Q37845036 | The many substrates of presenilin/γ-secretase |
| Q36582358 | The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid |
| Q35107623 | The secretases of Alzheimer's disease |
| Q34743288 | Therapeutic strategies for human amyloid diseases |
| Q53341825 | Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. |
| Q34744950 | Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase |
| Q26782403 | Vitamin D and Alzheimer's Disease: Neurocognition to Therapeutics |
| Q36674736 | γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling. |
| Q39545955 | γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio |
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