| P2093 | author name string | C Dingwall | |
| P2860 | cites work | Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state | Q22254058 |
| | Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor | Q27627346 |
| | Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties | Q28114877 |
| | Lipid rafts and signal transduction | Q28131735 |
| | Alzheimer's disease: genes, proteins, and therapy | Q28131806 |
| | Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1 | Q28139001 |
| | Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease | Q28140038 |
| | BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics | Q28201876 |
| | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor | Q28238069 |
| | Targeting of membrane proteins to endosomes and lysosomes | Q28612146 |
| | A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic Pathway | Q28612864 |
| | Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease | Q28910345 |
| | Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease | Q29614374 |
| | Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 |
| | Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides | Q30986734 |
| | Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production | Q31816667 |
| | Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation | Q32063777 |
| | BACE1 is the major beta-secretase for generation of Abeta peptides by neurons | Q32063781 |
| | Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline | Q33895797 |
| | Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. | Q33921362 |
| | Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo | Q34063772 |
| | Abeta-generating enzymes: recent advances in beta- and gamma-secretase research | Q34072320 |
| | Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts | Q34088442 |
| | Genes, models and Alzheimer's disease | Q34240266 |
| | Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities | Q36689365 |
| | The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain | Q40818712 |
| | A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase | Q40859157 |
| | L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity | Q40865987 |
| | Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease | Q40870554 |
| | Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells | Q40939308 |
| | Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase | Q40942994 |
| | Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein | Q41226800 |
| | Presenilins: genes for life and death | Q41496815 |
| | Processing of beta-secretase by furin and other members of the proprotein convertase family | Q43509576 |
| | Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain | Q43516537 |
| | Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology | Q43749044 |
| | Tau protein pathology in neurodegenerative diseases | Q48368290 |
| | Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease | Q48761995 |
| | Alzheimer's disease. In search of gamma-secretase. | Q52569584 |
| | A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. | Q53220934 |
| | Alzheimer's disease. A firm base for drug development. | Q53231809 |
| | Amyloid beta vaccination: reduced plaques and improved cognition. | Q53239669 |
| | Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. | Q53341822 |
| | Protofibrils, the unifying toxic molecule of neurodegenerative disorders? | Q53348485 |
| | The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities | Q71763263 |
| | The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation | Q73396476 |
| | Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease | Q77314168 |
| | gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length | Q77336168 |
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Alzheimer's disease | Q11081 |
| P304 | page(s) | 1243-6 | |
| P577 | publication date | 2001-11-01 | |
| P1433 | published in | Journal of Clinical Investigation | Q3186904 |
| P1476 | title | Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease | |
| P478 | volume | 108 | |