Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

scientific journal article

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M002095200
P698PubMed publication ID10887202

P2093author name stringS. Ross
T. Burgess
B. D. Bennett
M. Haniu
P. Denis
S. Kahn
M. Citron
J. Fuller
G. Rogers
V. Katta
Y. Young
R. Vassar
J. O. Hui
E. A. Mendiaz
P2860cites workMembrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activityQ22010912
Purification and cloning of amyloid precursor protein beta-secretase from human brainQ22010914
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)21099–21106
P577publication date2000-07-14
P1433published inJournal of Biological ChemistryQ867727
P1476titleCharacterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties
P478volume275

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cites work (P2860)
Q40859157A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase
Q31816631A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein
Q34072320Abeta-generating enzymes: recent advances in beta- and gamma-secretase research
Q36515891Activation of protein kinase C modulates BACE1-mediated beta-secretase activity
Q28477836Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging
Q36016766Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme
Q34566551Amyloid metabolism and secretases in Alzheimer's disease
Q34208401Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease
Q53240567Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors.
Q38493207Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates
Q31123558Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent
Q34156758BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease
Q38120669BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status
Q35809329BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice
Q32063781BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
Q33202614BACE1: the beta-secretase enzyme in Alzheimer's disease
Q30749785Beta-secretase (BACE) as a drug target for Alzheimer's disease
Q37866692Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors
Q34976280Beta-secretase as a target for the treatment of Alzheimer's disease
Q34066765Beta-secretase: structure, function, and evolution
Q37210063Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease
Q48217048Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis
Q37416750Cell biology, regulation and inhibition of beta-secretase (BACE-1).
Q30661499Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.
Q94464057Circulating Exosomal miRNA as Diagnostic Biomarkers of Neurodegenerative Diseases
Q34286933Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease
Q40672238Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme
Q97570180Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease
Q54111592Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models.
Q35019434Emerging Alzheimer's disease therapies: inhibition of beta-secretase
Q40674796Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation
Q28214776Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D
Q46818675Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.
Q34158282Enzymic properties of recombinant BACE2.
Q42049875Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells
Q33862796Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
Q48345479GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
Q40537045Human BACE forms dimers and colocalizes with APP.
Q37961866Identification and biology of β-secretase
Q40684851Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation
Q34080500In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase
Q36869427Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease
Q34007475Inhibition of BACE1 for therapeutic use in Alzheimer's disease
Q40545312Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein
Q37915426Intracellular trafficking of the β-secretase and processing of amyloid precursor protein
Q37781814Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions
Q37544756Mechanism-based treatments for Alzheimer's disease
Q36023269Membrane proteases in the bacterial protein secretion and quality control pathway
Q52655365Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation.
Q40014779NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.
Q30674796Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology
Q34180114Neurotoxic traffic: uncovering the mechanics of amyloid production in Alzheimer's disease
Q24292718PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein
Q28214125Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease
Q35009345Pharmacogenomics for the treatment of dementia
Q30486959Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis
Q33575863Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2
Q24803627Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH
Q34110227Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process
Q30494468Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway
Q40629788Recombinant insect cell expression and purification of human beta-secretase (BACE-1) for X-ray crystallography
Q34061109Regulation of APP cleavage by alpha-, beta- and gamma-secretases
Q37961881Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease
Q89287870Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement
Q28202553Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
Q57278508Sequential Virtual Screening Approach to the Identification of Small Organic Molecules as Potential BACE-1 Inhibitors
Q38059094Splice variants of the Alzheimer's disease beta-secretase, BACE1.
Q28363447Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease
Q37030825Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease
Q31032457Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases
Q36397690The Alzheimer's disease beta-secretase enzyme, BACE1.
Q37108142The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease
Q37987919The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond
Q37614747The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential
Q32061148The beta-secretase, BACE: a prime drug target for Alzheimer's disease
Q34398091The cell biology of Alzheimer's disease: uncovering the secrets of secretases
Q35570991The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal model
Q33722837The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.
Q28610071The normal and pathologic roles of the Alzheimer's β-secretase, BACE1
Q43510103The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase
Q37225050The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology
Q38127826The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors
Q90730208The β-Secretase BACE1 in Alzheimer's Disease
Q37884646The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
Q43715378Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production
Q26825722Trafficking regulation of proteins in Alzheimer's disease
Q38062499Transcriptional and post-transcriptional regulation of β-secretase.
Q40581861Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
Q46175385Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease
Q35140078gamma-Secretase inhibitors--from molecular probes to new therapeutics?
Q38785698miR-124 Regulates the Expression of BACE1 in the Hippocampus Under Chronic Cerebral Hypoperfusion
Q64892700pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo.
Q34240868Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis
Q36951145β-Secretase: its biology as a therapeutic target in diseases

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