| scholarly article | Q13442814 |
| P50 | author | Jeffrey S Nye | Q42873693 |
| P2093 | author name string | Chai-An Mao | |
| Ismail Kola | |||
| Kalpana M Merchant | |||
| Wenning Qin | |||
| Jinhe Li | |||
| Adele M Pauley | |||
| Gregory P Donoho | |||
| Carol S Himes | |||
| Richard L Myers | |||
| Gregory J Fici | |||
| Rongqing Shuang | |||
| P2860 | cites work | Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing | Q24290265 |
| Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation | Q24530721 | ||
| Skeletal and CNS defects in Presenilin-1-deficient mice | Q28238795 | ||
| Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein | Q28260479 | ||
| Processing of the Pre‐β‐amyloid Protein by Cathepsin d is Enhanced by a Familial Alzheimer's Disease Mutation | Q28286792 | ||
| Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency | Q28505078 | ||
| Mice lacking both presenilin genes exhibit early embryonic patterning defects | Q28508946 | ||
| Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm | Q28585594 | ||
| Nuclear access and action of notch in vivo | Q28646384 | ||
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
| Expression of a Delta homologue in prospective neurons in the chick | Q29619573 | ||
| Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate | Q34014078 | ||
| Abeta-generating enzymes: recent advances in beta- and gamma-secretase research | Q34072320 | ||
| The cell biology of Alzheimer's disease: uncovering the secrets of secretases | Q34398091 | ||
| gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? | Q34609917 | ||
| BiP binding keeps ATF6 at bay. | Q34731312 | ||
| The role of presenilin cofactors in the gamma-secretase complex | Q40661006 | ||
| PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin | Q40708428 | ||
| Identification and characterization of presenilin-independent Notch signaling | Q40760805 | ||
| A sensitive and quantitative assay for measuring cleavage of presenilin substrates | Q40763358 | ||
| A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling | Q40927150 | ||
| Drosophila nicastrin is essential for the intramembranous cleavage of notch | Q41473368 | ||
| Nicastrin binds to membrane-tethered Notch | Q43694706 | ||
| Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology | Q43749044 | ||
| Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila | Q47071721 | ||
| Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor | Q47072716 | ||
| Lack of requirement for presenilin1 in Notch1 signaling | Q50140758 | ||
| APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad. | Q52125379 | ||
| Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides. | Q52177773 | ||
| Notch1 is essential for postimplantation development in mice. | Q52512097 | ||
| Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. | Q53341825 | ||
| Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells. | Q53415286 | ||
| The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation | Q73396476 | ||
| Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1 | Q73949956 | ||
| P433 | issue | 35 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | murine model | Q122890741 |
| P1104 | number of pages | 5 | |
| P304 | page(s) | 33445-33449 | |
| P577 | publication date | 2003-06-18 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model | |
| P478 | volume | 278 |
| Q35590624 | A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases |
| Q36674481 | A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? |
| Q40976739 | Analysis of nicastrin gene phylogeny and expression in zebrafish. |
| Q37598601 | BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis |
| Q45068656 | BARHL1 Is Downregulated in Alzheimer's Disease and May Regulate Cognitive Functions through ESR1 and Multiple Pathways |
| Q26269918 | Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration |
| Q46527301 | Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model |
| Q56769946 | Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation |
| Q34752171 | Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex |
| Q37785197 | Gamma-secretase and the intramembrane proteolysis of Notch |
| Q34007475 | Inhibition of BACE1 for therapeutic use in Alzheimer's disease |
| Q28588005 | Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities |
| Q28306499 | Neprilysin activity and expression are controlled by nicastrin |
| Q24532080 | Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components |
| Q48527061 | Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in rats with a complex neurodevelopmental phenotype |
| Q37553976 | Protein SUMOylation in neuropathological conditions. |
| Q37108151 | Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease |
| Q26269843 | Synaptic function of nicastrin in hippocampal neurons |
| Q34677532 | The γ-secretase complex: from structure to function |
| Q34353695 | Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB |
| Q39894711 | gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity |
| Q40174843 | p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity |
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