| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.C100649200 |
| P698 | PubMed publication ID | 11744687 |
| P50 | author | Urban Lendahl | Q5946139 |
| Helena Karlström | Q49219574 | ||
| P2093 | author name string | Johan Lundkvist | |
| Jan Näslund | |||
| Anna Bergman | |||
| P2860 | cites work | Notch signaling: from the outside in | Q28139768 |
| A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain | Q28141707 | ||
| Presenilin is required for activity and nuclear access of Notch in Drosophila | Q28141718 | ||
| Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease | Q29614374 | ||
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
| Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline | Q33895797 | ||
| Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture | Q36255422 | ||
| Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals | Q36382397 | ||
| L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity | Q40865987 | ||
| Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes | Q40873515 | ||
| Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch | Q40883659 | ||
| Amyloid, the presenilins and Alzheimer's disease | Q41433661 | ||
| Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling | Q41748279 | ||
| Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts | Q43803920 | ||
| Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). | Q48092766 | ||
| Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. | Q53341825 | ||
| Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease | Q77314168 | ||
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 4 | |
| P304 | page(s) | 6763-6766 | |
| P577 | publication date | 2001-12-13 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | A sensitive and quantitative assay for measuring cleavage of presenilin substrates | |
| P478 | volume | 277 |
| Q24544042 | A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling. |
| Q35590624 | A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases |
| Q43197086 | A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis. |
| Q28185671 | A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex |
| Q33498093 | A miniaturized 1536-well format gamma-secretase assay |
| Q28263814 | A nine-transmembrane domain topology for presenilin 1 |
| Q36875846 | A novel high throughput 1536-well Notch1 γ -secretase AlphaLISA assay |
| Q40640846 | APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations |
| Q54270877 | Akt1 phosphorylates Nicastrin to regulate its protein stability and activity. |
| Q37195665 | Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio |
| Q48273082 | Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy |
| Q40077211 | Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages |
| Q82316332 | BMP and FGF-2 regulate neurogenin-2 expression and the differentiation of sensory neurons and glia |
| Q42526585 | Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor. |
| Q51667074 | Blockade of Notch Signalling by γ-Secretase Inhibitor in Lung T Cells of Asthmatic Mice Affects T Cell Differentiation and Pulmonary Inflammation. |
| Q40304488 | Caspase cleaved presenilin-1 is part of active gamma-secretase complexes |
| Q30363483 | Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations. |
| Q35652417 | Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches |
| Q51806299 | DNA damage-inducing agent-elicited gamma-secretase activity is dependent on Bax/Bcl-2 pathway but not on caspase cascades. |
| Q34718530 | FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. |
| Q44820325 | Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis |
| Q40541170 | Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins |
| Q36719274 | Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase |
| Q33243260 | Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies |
| Q37702688 | Inhibition of gamma-secretase in Notch1 signaling pathway as a novel treatment for ovarian cancer |
| Q59120502 | Intrinsic phenotypic diversity of embryonic and fetal myoblasts is revealed by genome-wide gene expression analysis on purified cells. |
| Q47754380 | Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays |
| Q24307727 | Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch |
| Q35000965 | Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. |
| Q38418887 | Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing |
| Q47693788 | NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. |
| Q37766757 | Notch and Wnt signaling, physiological stimuli and postnatal myogenesis |
| Q39649080 | Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells. |
| Q21146059 | Notch promotes neural lineage entry by pluripotent embryonic stem cells |
| Q52562489 | Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production. |
| Q34440371 | Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease. |
| Q28277779 | Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1 |
| Q59099262 | Peptides inhibiting specific cleaving activities of presenilins |
| Q40485801 | Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. |
| Q34271178 | Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways |
| Q44483354 | Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model |
| Q44257207 | Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy. |
| Q33378681 | Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements |
| Q41975088 | Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site |
| Q44287879 | Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage |
| Q47673255 | Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing. |
| Q46055931 | Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production. |
| Q28833244 | Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis |
| Q43177076 | The beta amyloid peptide can act as a modular aggregation domain |
| Q47753639 | The effect of downhill running on Notch signaling in regenerating skeletal muscle. |
| Q45025052 | The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity |
| Q33726342 | The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing |
| Q40379284 | gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity |
| Q36655033 | β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology |
| Q39545955 | γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio |
| Q26830462 | γ-Secretase inhibitors and modulators |
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