| P50 | author | Bengt Winblad | Q66000726 |
| P2093 | author name string | Johan Lundkvist | |
| | Jan Näslund | |
| | Anna Bergman | |
| | Hanna Laudon | |
| P2860 | cites work | Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state | Q22254058 |
| | Calsenilin reverses presenilin-mediated enhancement of calcium signaling | Q22254629 |
| | Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing | Q24290265 |
| | X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains | Q24290528 |
| | Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch | Q24307727 |
| | Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo | Q24315707 |
| | Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1 | Q28139001 |
| | Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans | Q28145545 |
| | Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide | Q28201180 |
| | A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 | Q28205099 |
| | Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins | Q28206918 |
| | Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment | Q28285327 |
| | Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch | Q28346677 |
| | Mice lacking both presenilin genes exhibit early embryonic patterning defects | Q28508946 |
| | Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 |
| | APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos | Q33894454 |
| | Notch receptor cleavage depends on but is not directly executed by presenilins | Q34021542 |
| | aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation | Q34137893 |
| | Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex | Q35105866 |
| | Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex | Q36381474 |
| | A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis | Q36690193 |
| | Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. | Q39659066 |
| | Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein | Q40576938 |
| | Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin | Q40599286 |
| | Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex | Q40600321 |
| | APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations | Q40640846 |
| | PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin | Q40708428 |
| | A sensitive and quantitative assay for measuring cleavage of presenilin substrates | Q40763358 |
| | The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins | Q40795556 |
| | Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases | Q40845419 |
| | Biochemistry. Intramembrane proteases--mixing oil and water | Q44037183 |
| | Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). | Q44270913 |
| | Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin | Q44511126 |
| | Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin | Q44529190 |
| | Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. | Q53341822 |
| P433 | issue | 44 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 45564-45572 | |
| P577 | publication date | 2004-08-20 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity | |
| P478 | volume | 279 | |