| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M011152200 |
| P698 | PubMed publication ID | 11432849 |
| P50 | author | Taisuke Tomita | Q37377652 |
| P2093 | author name string | Iwatsubo T | |
| De Strooper B | |||
| Kopan R | |||
| Watabiki T | |||
| Morohashi Y | |||
| Takasugi N | |||
| Takikawa R | |||
| P2860 | cites work | FASEB Journal | Q520194 |
| Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state | Q22254058 | ||
| Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. | Q53341825 | ||
| Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42 | Q59099431 | ||
| Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome | Q72107326 | ||
| Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1 | Q73949956 | ||
| Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors | Q74071559 | ||
| ??? | Q22251293 | ||
| Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing | Q24290265 | ||
| The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin | Q24308766 | ||
| Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo | Q24315707 | ||
| The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue | Q24564792 | ||
| Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1 | Q28139001 | ||
| A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain | Q28141707 | ||
| Presenilin is required for activity and nuclear access of Notch in Drosophila | Q28141718 | ||
| Endoproteolytic processing and stabilization of wild-type and mutant presenilin | Q28249607 | ||
| Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein | Q28260479 | ||
| Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain | Q28273268 | ||
| Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice | Q28300764 | ||
| Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency | Q28505078 | ||
| Mice lacking both presenilin genes exhibit early embryonic patterning defects | Q28508946 | ||
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
| A common enzyme connects notch signaling and Alzheimer's disease | Q34088470 | ||
| Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene | Q34296093 | ||
| Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch | Q35754149 | ||
| Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations | Q36386575 | ||
| Evidence for phosphorylation and oligomeric assembly of presenilin 1. | Q36765433 | ||
| Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2. | Q40815594 | ||
| Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases | Q40845419 | ||
| A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells | Q40851871 | ||
| Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes | Q40873515 | ||
| Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? | Q40918121 | ||
| Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis | Q40920138 | ||
| A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling | Q40927150 | ||
| Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation | Q40993693 | ||
| Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. | Q41007310 | ||
| Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. | Q41018706 | ||
| The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex | Q41062110 | ||
| Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). | Q48092766 | ||
| Subunit composition and ATP site labeling of the coated vesicle proton-translocating adenosinetriphosphatase | Q48193686 | ||
| Effects of PS1 deficiency on membrane protein trafficking in neurons | Q48327056 | ||
| Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi | Q48334621 | ||
| Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors | Q48602444 | ||
| Pathogenic presenilin 1 mutations (P436S & I143F) in early-onset Alzheimer's disease in the UK. Mutations in brief no. 223. Online. | Q52034904 | ||
| Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. | Q52583319 | ||
| An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. | Q53207278 | ||
| Two novel presenilin-1 mutations (Ser169Leu and Pro436Gln) associated with very early onset Alzheimer's disease. | Q53225126 | ||
| Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function. | Q53232745 | ||
| The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation. | Q53338153 | ||
| Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. | Q53341822 | ||
| P433 | issue | 35 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 33273-33281 | |
| P577 | publication date | 2001-06-29 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins | |
| P478 | volume | 276 |
| Q33991052 | A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity |
| Q36674481 | A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? |
| Q33972134 | Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator |
| Q40472890 | Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. |
| Q33327152 | Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease |
| Q37598601 | BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis |
| Q40348234 | C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation |
| Q46375029 | Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins |
| Q53969139 | Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. |
| Q90131515 | Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase |
| Q39332775 | Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein |
| Q28206724 | Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development |
| Q43963328 | FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants |
| Q42049875 | Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells |
| Q30876784 | Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase". |
| Q33924221 | Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. |
| Q40541170 | Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins |
| Q28206918 | Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins |
| Q34509775 | Metabolism of presenilins |
| Q24292312 | Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4 |
| Q42633798 | Molecular cloning, sequencing, and expression analysis of presenilin cDNA from Schistosoma mansoni |
| Q47155049 | Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease |
| Q73847604 | Oligomerization of human presenilin-1 fragments |
| Q39627819 | Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase |
| Q28277779 | Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1 |
| Q36109130 | Presenilin function and gamma-secretase activity |
| Q40447332 | Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. |
| Q42044384 | Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles |
| Q37459837 | Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. |
| Q37108151 | Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease |
| Q38098975 | Structural biology of presenilins and signal peptide peptidases |
| Q36899183 | Studies of the role of ubiquitination in the interaction of ubiquilin with the loop and carboxyl terminal regions of presenilin-2 |
| Q39972714 | The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase. |
| Q53628647 | The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase. |
| Q45025052 | The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity |
| Q40696144 | The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals |
| Q40619751 | The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity |
| Q40661006 | The role of presenilin cofactors in the gamma-secretase complex |
| Q36777475 | The study of Golgi apparatus in Alzheimer's disease |
| Q40379284 | gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity |
| Q34609917 | gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? |
| Q51735096 | γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor. |
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