| scholarly article | Q13442814 |
| P356 | DOI | 10.1111/J.1471-4159.2006.03881.X |
| P698 | PubMed publication ID | 16805816 |
| P50 | author | Alison Goate | Q45660395 |
| P2093 | author name string | Jun Wang | |
| Maribel Martinez | |||
| Emily S. Walker | |||
| P2860 | cites work | Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state | Q22254058 |
| Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing | Q24290265 | ||
| Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo | Q24315707 | ||
| Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Q24316501 | ||
| Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation | Q24530721 | ||
| Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1 | Q28118975 | ||
| APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes | Q28216835 | ||
| Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease | Q28241772 | ||
| Gamma-secretase complex assembly within the early secretory pathway | Q28297818 | ||
| APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development | Q28592373 | ||
| The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease | Q28610089 | ||
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
| Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two-dimensional native electrophoresis | Q29617482 | ||
| Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form | Q29619372 | ||
| Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo | Q34063772 | ||
| PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. | Q34169736 | ||
| Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene | Q34303468 | ||
| γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 | Q34648460 | ||
| Evidence for a physical interaction between presenilin and Notch | Q35071474 | ||
| Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation | Q35204147 | ||
| A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis | Q36690193 | ||
| Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. | Q37724159 | ||
| Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex. | Q40447129 | ||
| Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity. | Q40478080 | ||
| Mutations in APP have independent effects on Abeta and CTFgamma generation | Q40506128 | ||
| Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex | Q40600321 | ||
| Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain | Q40619177 | ||
| The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity | Q40619751 | ||
| The role of presenilin cofactors in the gamma-secretase complex | Q40661006 | ||
| Gamma-secretase activity is associated with a conformational change of nicastrin | Q40663039 | ||
| Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes | Q40676340 | ||
| PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin | Q40708428 | ||
| Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation | Q40716855 | ||
| Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease | Q43737357 | ||
| Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology | Q43749044 | ||
| gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation | Q44313369 | ||
| Reconstitution of gamma-secretase activity | Q44393107 | ||
| Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain | Q44405189 | ||
| Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model | Q44483354 | ||
| Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin | Q44511126 | ||
| The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex | Q44548884 | ||
| Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. | Q44930736 | ||
| Nicastrin functions as a gamma-secretase-substrate receptor | Q46646587 | ||
| Presenilins upregulate functional K+ channel currents in mammalian cells | Q47834643 | ||
| Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. | Q53341825 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 10 | |
| P304 | page(s) | 300-309 | |
| P577 | publication date | 2006-07-01 | |
| P1433 | published in | Journal of Neurochemistry | Q6295643 |
| P1476 | title | Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation | |
| P478 | volume | 98 |
| Q37598601 | BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis |
| Q36931020 | Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus |
| Q41846772 | High-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100 |
| Q37459837 | Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. |
| Q37108151 | Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease |
| Q42155167 | Structure of the transmembrane domain of human nicastrin-a component of γ-secretase |
| Q91908379 | Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies |
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