| scholarly article | Q13442814 |
| P50 | author | Thomas Kukar | Q42165296 |
| P2093 | author name string | Barbara A Cottrell | |
| Edward H Koo | |||
| Hiroko Maruyama | |||
| Pritam Das | |||
| Todd E Golde | |||
| Paul Robertson | |||
| Zhao Ren | |||
| Thomas B Ladd | |||
| Simone Eggert | |||
| Karen Jansen-West | |||
| Guriqbal S Basi | |||
| Brenda Moore | |||
| Sean A Pintchovski | |||
| Maralyssa A Bann | |||
| Kim Malphrus | |||
| P2860 | cites work | Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages | Q40077211 |
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| gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain | Q40374588 | ||
| Mutations in APP have independent effects on Abeta and CTFgamma generation | Q40506128 | ||
| The triplet of lysine residues (Lys724-Lys725-Lys726) of Alzheimer's amyloid precursor protein plays an important role in membrane anchorage and processing | Q41542810 | ||
| Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs | Q41822677 | ||
| Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability. | Q43697159 | ||
| Snorkeling of lysine side chains in transmembrane helices: how easy can it get? | Q44462799 | ||
| Electrophoretic mobility of Alzheimer’s amyloid-β peptides in urea–sodium dodecyl sulfate–polyacrylamide gel electrophoresis | Q44658826 | ||
| Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation | Q45078363 | ||
| A two-step procedure for efficient electrotransfer of both high-molecular-weight (greater than 400,000) and low-molecular-weight (less than 20,000) proteins | Q47196480 | ||
| Medicine. Avoiding unintended toxicity | Q47905309 | ||
| gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. | Q51776761 | ||
| Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. | Q51808780 | ||
| Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein | Q51837859 | ||
| Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor. | Q53532102 | ||
| gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length | Q77336168 | ||
| A novel substrate for analyzing Alzheimer's disease gamma-secretase | Q77998329 | ||
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics | Q27860914 | ||
| Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production | Q28245521 | ||
| The canonical Notch signaling pathway: unfolding the activation mechanism | Q29547725 | ||
| Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells | Q29614268 | ||
| Amyloid precursor protein trafficking, processing, and function | Q29617429 | ||
| Combinatorial alanine-scanning | Q30695340 | ||
| Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. | Q33207923 | ||
| GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. | Q33276402 | ||
| Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio | Q33516237 | ||
| Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease | Q33687945 | ||
| Beta-amyloid precursor protein mutants respond to gamma-secretase modulators | Q33885289 | ||
| How proteins adapt to a membrane-water interface | Q34023262 | ||
| Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization | Q34093329 | ||
| Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process | Q34110227 | ||
| Topogenic signals in integral membrane proteins | Q34167358 | ||
| Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein | Q35065215 | ||
| Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein | Q35562828 | ||
| Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1 | Q35626369 | ||
| Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease | Q35998995 | ||
| Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity | Q36423126 | ||
| A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? | Q36674481 | ||
| The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry | Q36835366 | ||
| Substrate specificity of gamma-secretase and other intramembrane proteases | Q37073568 | ||
| Substrate-targeting gamma-secretase modulators | Q37182828 | ||
| Molecular genetics of Alzheimer's disease: an update | Q37209771 | ||
| Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain. | Q37394529 | ||
| Orientation and dynamics of transmembrane peptides: the power of simple models | Q37658378 | ||
| Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. | Q39659066 | ||
| Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis | Q39695174 | ||
| Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay | Q40026669 | ||
| P433 | issue | 46 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | proteolysis | Q33123 |
| P304 | page(s) | 39804-39812 | |
| P577 | publication date | 2011-08-25 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region | |
| P478 | volume | 286 |
| Q48300002 | APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38. |
| Q28828789 | Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease? |
| Q47878038 | Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation. |
| Q35848336 | Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. |
| Q46277930 | Comparing the Aggregation Free Energy Landscapes of Amyloid Beta(1-42) and Amyloid Beta(1-40). |
| Q38737649 | Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators |
| Q37634392 | Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production |
| Q41447351 | Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase. |
| Q58771128 | Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein |
| Q38101383 | Development and mechanism of γ-secretase modulators for Alzheimer's disease |
| Q39623334 | Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2 |
| Q64990450 | Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators. |
| Q33707858 | FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage |
| Q30612060 | Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes. |
| Q35371482 | Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity |
| Q38543419 | Lipids in Amyloid-β Processing, Aggregation, and Toxicity |
| Q36479662 | Sampling the conformational space of the catalytic subunit of human γ-secretase |
| Q41733034 | Specific Binding of Cholesterol to C99 Domain of Amyloid Precursor Protein Depends Critically on Charge State of Protein. |
| Q37118735 | Steroids as γ-secretase modulators |
| Q52558853 | Structure of APP-C991-99 and implications for role of extra-membrane domains in function and oligomerization. |
| Q44967903 | Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology. |
| Q35562828 | Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein |
| Q27679405 | The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol |
| Q42092456 | The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase |
| Q38212604 | The role of cholesterol metabolism in Alzheimer's disease |
| Q42005373 | Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ. |
| Q39016079 | Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production |
| Q47156917 | β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing |
| Q26830462 | γ-Secretase inhibitors and modulators |
| Q35071626 | γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells |
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