| P50 | author | Prajwal Nandekar | Q57975356 |
| P2093 | author name string | Abhay T Sangamwar | |
| | Rameshwar Prajapati | |
| | Vijay Rathod | |
| | Sumit Jain | |
| P2860 | cites work | 2013 Alzheimer's disease facts and figures | Q86421768 |
| | 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin | Q24294476 |
| | The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions | Q24310512 |
| | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding | Q24657908 |
| | Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease | Q24673502 |
| | The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity | Q27632611 |
| | Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor | Q27641809 |
| | Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans | Q27673547 |
| | Inflammation and Alzheimer's disease | Q28138617 |
| | P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells | Q28167506 |
| | The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux | Q28186424 |
| | The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism | Q28206406 |
| | Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin | Q28211706 |
| | Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production | Q28245521 |
| | An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway | Q28263744 |
| | Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure | Q28366014 |
| | Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter | Q28375489 |
| | The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution | Q28378587 |
| | Consistent immunohistochemical detection of intracellular beta-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex | Q44214690 |
| | Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier | Q45025187 |
| | In vitro and ex vivo evidence for modulation of P-glycoprotein activity by progestins | Q45153382 |
| | Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. | Q45984382 |
| | In silico model for P-glycoprotein substrate prediction: insights from molecular dynamics and in vitro studies | Q46111336 |
| | Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals | Q46801572 |
| | A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza. | Q46960440 |
| | Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor | Q48123921 |
| | In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation | Q48473453 |
| | Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans | Q48476417 |
| | Diagnostic criteria for neuropathologic assessment of Alzheimer's disease | Q48662480 |
| | Blood-brain barrier P-glycoprotein function in Alzheimer's disease. | Q50778486 |
| | Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function. | Q51797588 |
| | Influence of passive permeability on apparent P-glycoprotein kinetics. | Q52065825 |
| | Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells. | Q52201976 |
| | Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. | Q53189340 |
| | Activation of microglial cells by beta-amyloid protein and interferon-gamma. | Q53202007 |
| | Reanalysis of the first case of Alzheimer's disease. | Q53232780 |
| | The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein. | Q54062696 |
| | HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: lovastatin specifically targets P-glycoprotein-expressing cells | Q71031979 |
| | Are the major effects of P-glycoprotein modulators due to altered pharmacokinetics of anticancer drugs? | Q71656347 |
| | Progesterone and its metabolites: the potent inhibitors of the transporting activity of P-glycoprotein in the adrenal gland | Q72659510 |
| | Induction of the multixenobiotic defense mechanism (MXR), P-glycoprotein, in the mussel Mytilus californianus as a general cellular response to environmental stresses | Q73800907 |
| | Alzheimer's Disease Pathology in Non-Demented Elderly | Q74736001 |
| | Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression | Q79434234 |
| | Structure and function of the blood-brain barrier | Q29615699 |
| | Membrane transporters in drug development | Q29616802 |
| | Structure of a bacterial multidrug ABC transporter | Q29617308 |
| | In situ localization of P-glycoprotein (ABCB1) in human and rat brain | Q33248008 |
| | Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance | Q33327324 |
| | Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites | Q33832954 |
| | Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease | Q33862071 |
| | P-glycoprotein, secretory transport, and other barriers to the oral delivery of anti-HIV drugs | Q33933495 |
| | ABC transporters and the blood-brain barrier | Q33978165 |
| | Drug resistance in brain diseases and the role of drug efflux transporters. | Q33988704 |
| | The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain | Q34065062 |
| | RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters | Q34090439 |
| | Interaction of common azole antifungals with P glycoprotein | Q34104641 |
| | Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. | Q34140197 |
| | Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors. | Q34283903 |
| | Drug efflux transporters in the CNS. | Q34530624 |
| | ABC multidrug transporters: structure, function and role in chemoresistance. | Q34586418 |
| | Drugs as P-glycoprotein substrates, inhibitors, and inducers | Q34627908 |
| | Bacterial multidrug resistance mediated by a homologue of the human multidrug transporter P-glycoprotein | Q34743834 |
| | Inflammatory proteins in plasma are associated with severity of Alzheimer's disease | Q34769550 |
| | Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice | Q35030142 |
| | Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease | Q35481648 |
| | Multidrug resistance reversal agents | Q35570886 |
| | St Johns wort increases expression of P-glycoprotein: implications for drug interactions | Q35804331 |
| | Importance of P-glycoprotein at blood-tissue barriers | Q35847121 |
| | ABC Transporters and the Alzheimer's Disease Enigma | Q36005085 |
| | Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine | Q36031211 |
| | Reversal of multidrug resistance in drug-resistant human gastric cancer cell line SGC7901/VCR by antiprogestin drug mifepristone | Q36065946 |
| | The translocation mechanism of P-glycoprotein. | Q36354417 |
| | Lipid formulation strategies for enhancing intestinal transport and absorption of P-glycoprotein (P-gp) substrate drugs: in vitro/in vivo case studies | Q36628366 |
| | Role of P-glycoprotein in statin drug interactions | Q36634221 |
| | A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease | Q36768052 |
| | Presenilin: running with scissors in the membrane | Q36979995 |
| | The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. | Q37390988 |
| | New treatment strategies for Alzheimer's disease: is there a hope? | Q37403383 |
| | Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects | Q37475474 |
| | New insight into p-glycoprotein as a drug target | Q38038886 |
| | Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response | Q38039759 |
| | Human pregnane X receptor: a novel target for anticancer drug development | Q38131272 |
| | Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens | Q38299812 |
| | Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers | Q39235872 |
| | Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters | Q39318483 |
| | Homology modeling and binding site assessment of the human P-glycoprotein | Q39766645 |
| | Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines | Q39795079 |
| | (+/-)-3'-O, 4'-O-dicynnamoyl-cis-khellactone, a derivative of (+/-)-praeruptorin A, reverses P-glycoprotein mediated multidrug resistance in cancer cells | Q40250249 |
| | Differential effects of the organochlorine pesticide DDT and its metabolite p,p'-DDE on p-glycoprotein activity and expression. | Q40458683 |
| | New 4-aryl-1,4-dihydropyridines and 4-arylpyridines as P-glycoprotein inhibitors | Q40483314 |
| | Mutations in APP have independent effects on Abeta and CTFgamma generation | Q40506128 |
| | Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice | Q40523453 |
| | Rapid assessment of P-glycoprotein inhibition and induction in vitro | Q40639122 |
| | Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding. | Q40667534 |
| | Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein | Q40685094 |
| | Interaction of cytochrome P450 3A inhibitors with P-glycoprotein | Q40703660 |
| | Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? | Q40729344 |
| | HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein | Q40789773 |
| | Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4. | Q40834126 |
| | Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion | Q40906509 |
| | Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells | Q40993638 |
| | Inflammation and Alzheimer disease | Q41167374 |
| | Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein | Q41225729 |
| | Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. | Q41233919 |
| | Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers | Q41436304 |
| | 17 beta-estradiol glucuronide: an inducer of cholestasis and a physiological substrate for the multidrug resistance transporter | Q41514325 |
| | Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone | Q41590183 |
| | A cell line with unusual characteristics from an ovarian carcinoma patient: modulation of sensitivity to antitumour drugs | Q41649966 |
| | P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model | Q41844698 |
| | Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A. | Q42468095 |
| | The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease | Q42470207 |
| | Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein | Q42552510 |
| | Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. | Q42822983 |
| | Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin | Q42831234 |
| | Transfer of bisphenol A across the human placenta. | Q43115691 |
| | Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone | Q43122836 |
| | St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier | Q43129877 |
| | Modulation of P-glycoprotein ATPase activity by some phytoconstituents | Q43298905 |
| | P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain | Q43815938 |
| | Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. | Q43958807 |
| | Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors | Q43974257 |
| | Evidence for p-glycoprotein modification of insecticide toxicity in mosquitoes of the Culex pipiens complex | Q44057253 |
| | P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats | Q44061513 |
| P433 | issue | 4 | |
| P921 | main subject | Alzheimer's disease | Q11081 |
| P304 | page(s) | 895-909 | |
| P577 | publication date | 2014-09-12 | |
| P1433 | published in | Molecular Diversity | Q3319469 |
| P1476 | title | Pregnane X Receptor and P-glycoprotein: a connexion for Alzheimer's disease management | |
| P478 | volume | 18 | |