| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/J.MAM.2009.04.002 |
| P698 | PubMed publication ID | 19427329 |
| P2093 | author name string | Paolo Ascenzi | |
| Maria Marino | |||
| Alessandra di Masi | |||
| Elisabetta De Marinis | |||
| P2860 | cites work | Initial sequencing and analysis of the human genome | Q21045365 |
| Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene | Q40079327 | ||
| P433 | issue | 5 | |
| P304 | page(s) | 297-343 | |
| P577 | publication date | 2009-05-07 | |
| P1433 | published in | Molecular Aspects of Medicine | Q6895933 |
| P1476 | title | Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects | |
| P478 | volume | 30 |
| Q39018278 | A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies |
| Q36502944 | A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy. |
| Q36801931 | A concentration addition model to assess activation of the pregnane X receptor (PXR) by pesticide mixtures found in the French diet |
| Q64900450 | A current structural perspective on PXR and CAR in drug metabolism. |
| Q27658908 | A structural view of nuclear hormone receptor: endocrine disruptor interactions |
| Q42698187 | Accessing the molecular interactions of phthalates and their primary metabolites with the human pregnane X receptor using in silico profiling |
| Q33742134 | Activation of xenobiotic receptors: driving into the nucleus |
| Q38211210 | Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery |
| Q39416595 | Affinity purification using recombinant PXR as a tool to characterize environmental ligands. |
| Q36939547 | Altered drug metabolism during pregnancy: hormonal regulation of drug-metabolizing enzymes |
| Q38038498 | An overview of transcriptional regulation in response to toxicological insult. |
| Q38011191 | An update on the ability of St. John's wort to affect the metabolism of other drugs |
| Q38844850 | Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling. |
| Q53080545 | Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib. |
| Q64252884 | Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity |
| Q92781890 | Benzo[ a]pyrene Induction of Glutathione S-Transferases: An Activity-Based Protein Profiling Investigation |
| Q35531860 | CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor |
| Q34921957 | Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor |
| Q34553662 | Cell-based systems to assess nuclear receptor activation and their use in drug development |
| Q57145981 | Characterization and treatment of persistent hepatocellular secretory failure |
| Q40759673 | Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons |
| Q39448680 | Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer |
| Q33833363 | Colonization-induced host-gut microbial metabolic interaction |
| Q50064516 | Constitutive activity and ligand-dependent activation of the nuclear receptor CAR-insights from molecular dynamics simulations |
| Q36667044 | Coordinated roles of pregnane X receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice |
| Q64056552 | DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene |
| Q50249231 | Determination of CYP3A4 Inducing Properties of Compounds Using a Laboratory-Developed Cell-Based Assay |
| Q36493995 | Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor |
| Q36254041 | Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms |
| Q37184675 | Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor |
| Q39593078 | Dimethylesculetin ameliorates maternal glucose intolerance and fetal overgrowth in high-fat diet-fed pregnant mice via constitutive androstane receptor |
| Q28080874 | Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
| Q37509532 | Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children |
| Q58549943 | Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression |
| Q39474573 | Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor |
| Q38862327 | Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics |
| Q38046892 | Enzyme induction with antiepileptic drugs: cause for concern? |
| Q39747519 | Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds |
| Q47717137 | Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine |
| Q33742719 | Evaluation of the HC-04 cell line as an in vitro model for mechanistic assessment of changes in hepatic cytochrome P450 3A during adenovirus infection |
| Q64958249 | Evolutionary Plasticity in Detoxification Gene Modules: The Preservation and Loss of the Pregnane X Receptor in Chondrichthyes Lineages. |
| Q33636734 | Evolutionary history and functional characterization of the amphibian xenosensor CAR. |
| Q30391745 | Exploration of the conformational landscape in pregnane X receptor reveals a new binding pocket |
| Q58577529 | Exploring the PXR ligand binding mechanism with advanced Molecular Dynamics methods |
| Q39424402 | Fate of steroid hormones and endocrine activities in swine manure disposal and treatment facilities |
| Q33941218 | Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver |
| Q42864265 | Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans |
| Q49332317 | Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability |
| Q36105916 | Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening |
| Q91683566 | Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library |
| Q91906950 | Impact of NR1I2, adenosine triphosphate-binding cassette transporters genetic polymorphisms on the pharmacokinetics of ginsenoside compound K in healthy Chinese volunteers |
| Q50054167 | In vivo deletion of CAR resulted in high bone mass phenotypes in male mice |
| Q58794880 | In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets |
| Q51137347 | Influence of a critical single nucleotide polymorphism on nuclear receptor PXR-promoter function. |
| Q37113947 | Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors. |
| Q34664123 | Interactions between meat intake and genetic variation in relation to colorectal cancer |
| Q50047208 | Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines |
| Q90381179 | Marine Ligands of the Pregnane X Receptor (PXR): An Overview |
| Q39029172 | Marked differences in the effect of antiepileptic and cytostatic drugs on the functionality of P-glycoprotein in human and rat brain capillary endothelial cell lines |
| Q89140618 | Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction |
| Q38733688 | Mechanisms of xenobiotic receptor activation: Direct vs. indirect |
| Q38209734 | Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis |
| Q34904938 | Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). |
| Q27009230 | Modulation of xenobiotic receptors by steroids |
| Q36549795 | Molecular Interactions between NAFLD and Xenobiotic Metabolism. |
| Q26770365 | Molecular Mechanisms of Action of BPA |
| Q36124179 | Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver |
| Q59797226 | Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases |
| Q64268548 | Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD |
| Q38588866 | Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging |
| Q46093226 | Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells |
| Q38135859 | Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier. |
| Q40241810 | ONRLDB--manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery. |
| Q40036535 | Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation |
| Q35141351 | Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes. |
| Q36640752 | PXR antagonists and implication in drug metabolism |
| Q34129977 | PXR variants and artemisinin use in Vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin |
| Q89823391 | PXR: a center of transcriptional regulation in cancer |
| Q34487187 | Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease |
| Q33690892 | Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes |
| Q38170449 | Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily. |
| Q28072512 | Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions |
| Q38248506 | Pregnane X Receptor and P-glycoprotein: a connexion for Alzheimer's disease management |
| Q42513322 | Quantitative analysis of the interaction of constitutive androstane receptor with chemicals and steroid receptor coactivator 1 using surface plasmon resonance biosensor systems: a case study of the Baikal seal (Pusa sibirica) and the mouse. |
| Q34384195 | Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands |
| Q28484352 | Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor |
| Q37756178 | Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. |
| Q35591361 | Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors. |
| Q35848854 | Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins |
| Q36672089 | Role of CAR and PXR in xenobiotic sensing and metabolism |
| Q26827398 | Role of pregnane X receptor in chemotherapeutic treatment |
| Q38759057 | SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells |
| Q35938150 | Small-molecule modulators of PXR and CAR. |
| Q28538476 | Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor |
| Q27322581 | Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation |
| Q27012669 | Targeting xenobiotic receptors PXR and CAR in human diseases |
| Q58573310 | Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling |
| Q57179384 | The Nuclear Receptor Field: A Historical Overview and Future Challenges |
| Q88669494 | The Roles of Xenobiotic Receptors: Beyond Chemical Disposition |
| Q37030715 | The impact of genetic polymorphisms on the pharmacokinetics of efavirenz in African children |
| Q46208435 | The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes. |
| Q38327914 | The novel antibacterial compound walrycin A induces human PXR transcriptional activity |
| Q52731004 | The pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma. |
| Q38750759 | The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors |
| Q34614106 | Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1. |
| Q24293759 | Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4α/CAR/RXR/PSF complex |
| Q47682229 | Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice |
| Q38695411 | Use antibiotics in cell culture with caution: genome-wide identification of antibiotic-induced changes in gene expression and regulation. |
| Q47636283 | Vitamin C protects piglet liver against zearalenone-induced oxidative stress by modulating expression of nuclear receptors PXR and CAR and their target genes |
| Q36602403 | Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells |
| Q36931713 | Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective |
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