scholarly article | Q13442814 |
P50 | author | Tal Burstyn-Cohen | Q47390869 |
Inna Slutsky | Q48924490 | ||
Ehud Cohen | Q37834766 | ||
P2093 | author name string | Joan C Marini | |
Wayne A Cabral | |||
Dinorah Friedmann-Morvinski | |||
Tziona Ben-Gedalya | |||
Lorna Moll | |||
Michal Bejerano-Sagie | |||
Samuel Frere | |||
P2860 | cites work | Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta | Q21144869 |
The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein | Q22010198 | ||
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins | Q24293182 | ||
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo | Q24315707 | ||
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Q24316501 | ||
Prions | Q24633319 | ||
Inhibition of p97-dependent protein degradation by Eeyarestatin I | Q24648805 | ||
Misfolded proteins partition between two distinct quality control compartments | Q24651093 | ||
Mouse models of frontotemporal dementia | Q26829009 | ||
Widespread protein aggregation as an inherent part of aging in C. elegans | Q27323997 | ||
A genetic screening strategy identifies novel regulators of the proteostasis network | Q27335238 | ||
Folding proteins in fatal ways | Q28235206 | ||
Inducible proteopathies | Q28249025 | ||
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein | Q28260479 | ||
Targeting proteins for degradation | Q28261886 | ||
Aggresomes: a cellular response to misfolded proteins | Q28292275 | ||
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency | Q28505078 | ||
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations | Q28506710 | ||
Alzheimer's disease: the amyloid cascade hypothesis | Q29547160 | ||
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
Opposing activities protect against age-onset proteotoxicity | Q29619758 | ||
Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartments | Q43686837 | ||
gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation | Q44313369 | ||
Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. | Q45987250 | ||
Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome | Q46931937 | ||
Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease | Q47816515 | ||
Brain pathology in three subjects from the same pedigree with presenilin-1 (PSEN1) P264L mutation | Q48427174 | ||
Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. | Q48679471 | ||
Localization of presenilin-1 mRNA in rat brain | Q48864088 | ||
Aging as a major risk for degenerative diseases of the central nervous system. | Q53314938 | ||
Alzheimer's disease | Q84113248 | ||
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans | Q29619760 | ||
Termination of autophagy and reformation of lysosomes regulated by mTOR | Q29619817 | ||
Cyclophilin: a specific cytosolic binding protein for cyclosporin A | Q29620548 | ||
Multidomain Peptidyl Prolyl cis/trans Isomerases | Q30316949 | ||
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice | Q30497845 | ||
Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways | Q30502208 | ||
The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ | Q31779663 | ||
Photobleaching and photoactivation: following protein dynamics in living cells | Q33973202 | ||
Chaperone-mediated autophagy in protein quality control | Q34150995 | ||
The nascent polypeptide-associated complex is a key regulator of proteostasis | Q34340544 | ||
Molecular chaperone functions in protein folding and proteostasis | Q34349321 | ||
Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells. | Q34463706 | ||
Active gamma-secretase complexes contain only one of each component | Q34655171 | ||
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses | Q34831241 | ||
Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems | Q35160159 | ||
Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease | Q35174706 | ||
The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism | Q35578655 | ||
Mammalian prion biology: one century of evolving concepts | Q35639302 | ||
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease | Q36000134 | ||
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease | Q36382102 | ||
Frontotemporal dementia-like phenotypes associated with presenilin-1 mutations | Q36583604 | ||
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease | Q36934762 | ||
Presenilin: running with scissors in the membrane | Q36979995 | ||
From presenilinase to gamma-secretase, cleave to capacitate | Q37130659 | ||
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. | Q37200867 | ||
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria | Q37413630 | ||
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease | Q37463481 | ||
Prions: protein aggregation and infectious diseases | Q37605469 | ||
Quality control compartments coming of age. | Q37978890 | ||
A novel quality control compartment derived from the endoplasmic reticulum | Q38761990 | ||
A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity | Q39059383 | ||
Mutations in APP have independent effects on Abeta and CTFgamma generation | Q40506128 | ||
Mutations of the presenilin I gene in families with early-onset Alzheimer's disease | Q41263613 | ||
Variant Gerstmann-Sträussler syndrome with the P105L prion gene mutation: an unusual case with nigral degeneration and widespread neurofibrillary tangles | Q42479364 | ||
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease. | Q42635301 | ||
PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress | Q42825463 | ||
P4510 | describes a project that uses | ImageJ | Q1659584 |
P433 | issue | 22 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Alzheimer's disease | Q11081 |
P1104 | number of pages | 20 | |
P304 | page(s) | 2820-2839 | |
P577 | publication date | 2015-10-05 | |
P1433 | published in | The EMBO Journal | Q1278554 |
P1476 | title | Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction | |
P478 | volume | 34 |
Q92932312 | Alzheimer's disease: amyloid-based pathogenesis and potential therapies |
Q46159810 | Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease |
Q90737132 | Exploring Alzheimer's Disease Molecular Variability via Calculation of Personalized Transcriptional Signatures |
Q42746241 | From mutated genes to familial Alzheimer's disease |
Q36030348 | Meta-Analysis of Serum Insulin-Like Growth Factor 1 in Alzheimer's Disease |
Q28078428 | Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries |
Q37343988 | PSEN1 L226F mutation in a patient with early-onset Alzheimer's disease in Korea |
Q46498597 | PrP-containing aggresomes are cytosolic components of an ER quality control mechanism. |
Q38793449 | Protein Quality Control in Health and Disease |
Q39145994 | The Emerging Roles of Early Protein Folding Events in the Secretory Pathway in the Development of Neurodegenerative Maladies |
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