Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.

scientific article

Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.15252/EMBJ.201592042
P932PMC publication ID4682640
P698PubMed publication ID26438723
P5875ResearchGate publication ID282654254

P50authorTal Burstyn-CohenQ47390869
Inna SlutskyQ48924490
Ehud CohenQ37834766
P2093author name stringJoan C Marini
Wayne A Cabral
Dinorah Friedmann-Morvinski
Tziona Ben-Gedalya
Lorna Moll
Michal Bejerano-Sagie
Samuel Frere
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The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau proteinQ22010198
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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivoQ24315707
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseQ24316501
PrionsQ24633319
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Misfolded proteins partition between two distinct quality control compartmentsQ24651093
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Widespread protein aggregation as an inherent part of aging in C. elegansQ27323997
A genetic screening strategy identifies novel regulators of the proteostasis networkQ27335238
Folding proteins in fatal waysQ28235206
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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor proteinQ28260479
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Aggresomes: a cellular response to misfolded proteinsQ28292275
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyQ28505078
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutationsQ28506710
Alzheimer's disease: the amyloid cascade hypothesisQ29547160
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activityQ29616491
Opposing activities protect against age-onset proteotoxicityQ29619758
Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartmentsQ43686837
gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylationQ44313369
Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.Q45987250
Linkage of a prion protein missense variant to Gerstmann-Sträussler syndromeQ46931937
Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's diseaseQ47816515
Brain pathology in three subjects from the same pedigree with presenilin-1 (PSEN1) P264L mutationQ48427174
Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.Q48679471
Localization of presenilin-1 mRNA in rat brainQ48864088
Aging as a major risk for degenerative diseases of the central nervous system.Q53314938
Alzheimer's diseaseQ84113248
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegansQ29619760
Termination of autophagy and reformation of lysosomes regulated by mTORQ29619817
Cyclophilin: a specific cytosolic binding protein for cyclosporin AQ29620548
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Reduced IGF-1 signaling delays age-associated proteotoxicity in miceQ30497845
Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathwaysQ30502208
The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situQ31779663
Photobleaching and photoactivation: following protein dynamics in living cellsQ33973202
Chaperone-mediated autophagy in protein quality controlQ34150995
The nascent polypeptide-associated complex is a key regulator of proteostasisQ34340544
Molecular chaperone functions in protein folding and proteostasisQ34349321
Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells.Q34463706
Active gamma-secretase complexes contain only one of each componentQ34655171
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analysesQ34831241
Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systemsQ35160159
Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's diseaseQ35174706
The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanismQ35578655
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The mechanism of γ-Secretase dysfunction in familial Alzheimer diseaseQ36000134
Upregulated function of mitochondria-associated ER membranes in Alzheimer diseaseQ36382102
Frontotemporal dementia-like phenotypes associated with presenilin-1 mutationsQ36583604
Neuronal calcium mishandling and the pathogenesis of Alzheimer's diseaseQ36934762
Presenilin: running with scissors in the membraneQ36979995
From presenilinase to gamma-secretase, cleave to capacitateQ37130659
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.Q37200867
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondriaQ37413630
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's diseaseQ37463481
Prions: protein aggregation and infectious diseasesQ37605469
Quality control compartments coming of age.Q37978890
A novel quality control compartment derived from the endoplasmic reticulumQ38761990
A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicityQ39059383
Mutations in APP have independent effects on Abeta and CTFgamma generationQ40506128
Mutations of the presenilin I gene in families with early-onset Alzheimer's diseaseQ41263613
Variant Gerstmann-Sträussler syndrome with the P105L prion gene mutation: an unusual case with nigral degeneration and widespread neurofibrillary tanglesQ42479364
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.Q42635301
PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stressQ42825463
P4510describes a project that usesImageJQ1659584
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P1104number of pages20
P304page(s)2820-2839
P577publication date2015-10-05
P1433published inThe EMBO JournalQ1278554
P1476titleAlzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction
P478volume34

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cites work (P2860)
Q92932312Alzheimer's disease: amyloid-based pathogenesis and potential therapies
Q46159810Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease
Q90737132Exploring Alzheimer's Disease Molecular Variability via Calculation of Personalized Transcriptional Signatures
Q42746241From mutated genes to familial Alzheimer's disease
Q36030348Meta-Analysis of Serum Insulin-Like Growth Factor 1 in Alzheimer's Disease
Q28078428Mutations, associated with early-onset Alzheimer's disease, discovered in Asian countries
Q37343988PSEN1 L226F mutation in a patient with early-onset Alzheimer's disease in Korea
Q46498597PrP-containing aggresomes are cytosolic components of an ER quality control mechanism.
Q38793449Protein Quality Control in Health and Disease
Q39145994The Emerging Roles of Early Protein Folding Events in the Secretory Pathway in the Development of Neurodegenerative Maladies

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