Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

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Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development is …
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scholarly articleQ13442814

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P356DOI10.1021/ML4000657
P8608Fatcat IDrelease_fnzukap4lzegzojx2aldkwy3pu
P3181OpenCitations bibliographic resource ID1648199
P932PMC publication ID4027145
P698PubMed publication ID24900694

P2093author name stringNan Jiang
Kathryn Packman
Allen Lovey
Jin-Jun Liu
Yang Wen
Christian Tovar
Kelli Glenn
Lyubomir Vassilev
Chunlin Zhao
Binh Vu
Bradford Graves
Giacomo Pizzolato
Peter Wovkulich
Qingjie Ding
P2860cites workStructure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domainQ24314763
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
Structure-based design of novel inhibitors of the MDM2-p53 interactionQ27678657
MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer modelsQ27683975
Regulation of p53 stability by Mdm2Q27860744
p53, the cellular gatekeeper for growth and divisionQ27860990
Surfing the p53 networkQ28032484
Functions of the MDM2 oncoproteinQ28138115
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationQ28280958
The p53 pathway: positive and negative feedback loopsQ29617535
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.Q33211997
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism studyQ33403930
p53 and human cancer: the first ten thousand mutations.Q33767112
Regulation of p53 stabilityQ33807793
MDM2 is a central node in the p53 pathway: 12 years and countingQ34395797
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapyQ34478557
Awakening guardian angels: drugging the p53 pathwayQ35014385
MDM2, an introduction.Q35621040
MDM2 inhibitors for cancer therapyQ36663493
Small-Molecule Inhibitors of the p53-MDM2 InteractionQ37806669
Recent advances in the therapeutic perspectives of Nutlin-3.Q37851525
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.Q40270647
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectorganic chemistryQ11351
drug discoveryQ1418791
P304page(s)466-9
P577publication date2013-05-09
P1433published inACS Medicinal Chemistry LettersQ2819061
P1476titleDiscovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
P478volume4

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