scholarly article | Q13442814 |
P356 | DOI | 10.1021/ML4000657 |
P8608 | Fatcat ID | release_fnzukap4lzegzojx2aldkwy3pu |
P3181 | OpenCitations bibliographic resource ID | 1648199 |
P932 | PMC publication ID | 4027145 |
P698 | PubMed publication ID | 24900694 |
P2093 | author name string | Nan Jiang | |
Kathryn Packman | |||
Allen Lovey | |||
Jin-Jun Liu | |||
Yang Wen | |||
Christian Tovar | |||
Kelli Glenn | |||
Lyubomir Vassilev | |||
Chunlin Zhao | |||
Binh Vu | |||
Bradford Graves | |||
Giacomo Pizzolato | |||
Peter Wovkulich | |||
Qingjie Ding | |||
P2860 | cites work | Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain | Q24314763 |
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
Structure-based design of novel inhibitors of the MDM2-p53 interaction | Q27678657 | ||
MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models | Q27683975 | ||
Regulation of p53 stability by Mdm2 | Q27860744 | ||
p53, the cellular gatekeeper for growth and division | Q27860990 | ||
Surfing the p53 network | Q28032484 | ||
Functions of the MDM2 oncoprotein | Q28138115 | ||
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation | Q28280958 | ||
The p53 pathway: positive and negative feedback loops | Q29617535 | ||
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. | Q33211997 | ||
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study | Q33403930 | ||
p53 and human cancer: the first ten thousand mutations. | Q33767112 | ||
Regulation of p53 stability | Q33807793 | ||
MDM2 is a central node in the p53 pathway: 12 years and counting | Q34395797 | ||
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy | Q34478557 | ||
Awakening guardian angels: drugging the p53 pathway | Q35014385 | ||
MDM2, an introduction. | Q35621040 | ||
MDM2 inhibitors for cancer therapy | Q36663493 | ||
Small-Molecule Inhibitors of the p53-MDM2 Interaction | Q37806669 | ||
Recent advances in the therapeutic perspectives of Nutlin-3. | Q37851525 | ||
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. | Q40270647 | ||
P433 | issue | 5 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | organic chemistry | Q11351 |
drug discovery | Q1418791 | ||
P304 | page(s) | 466-9 | |
P577 | publication date | 2013-05-09 | |
P1433 | published in | ACS Medicinal Chemistry Letters | Q2819061 |
P1476 | title | Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development | |
P478 | volume | 4 |
Q93197932 | A patent review of the ubiquitin ligase system: 2015-2018 |
Q35620999 | Alternative modulation of protein-protein interactions by small molecules |
Q60923023 | An Application of Fit Quality to Screen MDM2/p53 Protein-Protein Interaction Inhibitors |
Q49565626 | Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics |
Q92073027 | Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs |
Q26749008 | Chemical Variations on the p53 Reactivation Theme |
Q51299491 | Clinical pharmacology characterization of RG7112, an MDM2 antagonist, in patients with advanced solid tumors. |
Q42378380 | Combination treatment with rucaparib (Rubraca) and MDM2 inhibitors, Nutlin-3 and RG7388, has synergistic and dose reduction potential in ovarian cancer |
Q27684203 | Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction Inhibitor |
Q89823393 | Degradation of proteins by PROTACs and other strategies |
Q35859325 | Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities |
Q90162056 | Design, Synthesis, and Biological Evaluation of Aromatic Amide-Substituted Benzimidazole-Derived Chalcones. The Effect of Upregulating TP53 Protein Expression |
Q34358585 | Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors |
Q64239493 | Development and structural characterization of an engineered multi-copper oxidase reporter of protein-protein interactions |
Q30670705 | Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and in |
Q33572704 | Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine [...] |
Q90331262 | Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression |
Q34063712 | Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction |
Q38191796 | Drugging the p53 pathway: understanding the route to clinical efficacy |
Q88334098 | Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia |
Q94952548 | Emerging New Concepts of Degrader Technologies |
Q58697064 | Evolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery |
Q92084382 | Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists |
Q42217007 | Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. |
Q35871210 | How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures. |
Q34545841 | Induced protein degradation: an emerging drug discovery paradigm |
Q91923645 | Inhibition of p53 inhibitors: progress, challenges and perspectives |
Q35925277 | Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds |
Q42651903 | MDM2 Antagonists Counteract Drug-Induced DNA Damage. |
Q91755518 | MDM2 antagonists as a novel treatment option for acute myeloid leukemia: perspectives on the therapeutic potential of idasanutlin (RG7388) |
Q97531386 | MDM2 inhibition: an important step forward in cancer therapy |
Q38865504 | Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction. |
Q26775356 | Modulation of Protein-Protein Interactions for the Development of Novel Therapeutics |
Q90024713 | Non-genotoxic MDM2 inhibition selectively induces a pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells |
Q38195457 | Oncogenic protein interfaces: small molecules, big challenges. |
Q33998827 | Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition |
Q34481459 | Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions |
Q38872029 | Pharmacological activation of wild-type p53 in the therapy of leukemia |
Q38286198 | Pharmacological reactivation of p53 as a strategy to treat cancer. |
Q90322572 | Potent effect of the MDM2 inhibitor AMG232 on suppression of glioblastoma stem cells |
Q36828178 | Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas |
Q37433613 | Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale. |
Q96690650 | Rationally Designed Polypharmacology: α-Helix Mimetics as Dual Inhibitors of the Oncoproteins Mcl-1 and HDM2 |
Q38825845 | Reactivation of p53 via MDM2 inhibition |
Q99616637 | Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials |
Q36140846 | Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells. |
Q55386099 | Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome. |
Q96348276 | Regulating tumor suppressor genes: post-translational modifications |
Q38238600 | Resistance acquisition to MDM2 inhibitors. |
Q36734163 | Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia |
Q39205536 | Reviving the guardian of the genome: Small molecule activators of p53. |
Q35411745 | Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach |
Q93166847 | Selective Inhibitors of T Cell Receptor Recognition of Antigen-MHC Complexes for Rheumatoid Arthritis |
Q42544825 | Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions |
Q35555133 | Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions |
Q89629372 | Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and independent effects by CDK6-specific PROTACs |
Q98612686 | Senotherapeutic drugs for human intervertebral disc degeneration and low back pain |
Q28548249 | Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment |
Q91558966 | Simultaneous measurement of p53:Mdm2 and p53:Mdm4 protein-protein interactions in whole cells using fluorescence labelled foci |
Q54992503 | Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets. |
Q35617077 | Small-molecule MDM2-p53 inhibitors: recent advances |
Q98894841 | Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives |
Q35087851 | Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment. |
Q35738960 | State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors |
Q39747547 | Structure- and ligand-based virtual screening identifies new scaffolds for inhibitors of the oncoprotein MDM2. |
Q89927396 | Synthesis, Biological Evaluation and Modeling Studies of New Pyrido[3,4-b]indole Derivatives as Broad-Spectrum Potent Anticancer Agents |
Q58726403 | Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions |
Q35687836 | Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies? |
Q38749151 | Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges. |
Q37158445 | Targeting ubiquitination for cancer therapies. |
Q50448531 | The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene. |
Q36692848 | The MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma |
Q47096280 | The Role of MDM2 in Promoting Genome Stability versus Instability. |
Q38637803 | The clinical and therapeutic uses of MDM2 and PSMA and their potential interaction in aggressive cancers. |
Q57162865 | The p53 Pathway in Glioblastoma |
Q92799263 | The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors |
Q90093670 | The role of ubiquitination in tumorigenesis and targeted drug discovery |
Q40688335 | The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors |
Q91701515 | p53 modifications: exquisite decorations of the powerful guardian |