The crystal structure of pertussis toxin

scientific article

The crystal structure of pertussis toxin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0969-2126(00)00007-1
P3181OpenCitations bibliographic resource ID547970
P698PubMed publication ID8075982

P2093author name stringG D Armstrong
R J Read
A Boodhoo
M H Klein
P E Stein
S A Cockle
P2860cites workA unique sequence of the Bordetella pertussis toxin operonQ40538308
Stimulation of the thiol-dependent ADP-ribosyltransferase and NAD glycohydrolase activities of Bordetella pertussis toxin by adenine nucleotides, phospholipids, and detergentsQ41848419
Preliminary X-ray crystallographic analysis of holotoxin from Bordetella pertussisQ44601288
Protein-chemical analysis of pertussis toxin reveals homology between the subunits S2 and S3, between S1 and the A chains of enterotoxins of Vibrio cholerae and Escherichia coli and identifies S2 as the haptoglobin-binding subunitQ45045481
'Pertussis vaccine encephalopathy': it is time to recognize it as the myth that it is.Q49052896
The detection and classification of membrane-spanning proteins.Q52669730
A novel process for preparing an acellular pertussis vaccine composed of non-pyrogenic toxoids of pertussis toxin and filamentous hemagglutinin.Q53862264
Separation and characterization of two distinct hemagglutinins contained in purified leukocytosis-promoting factor from Bordetella pertussisQ54607284
Comparison of the B-pentamers of heat-labile enterotoxin and verotoxin-1: two structures with remarkable similarity and dissimilarity.Q54663458
Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli.Q54696665
A phased translation functionQ56877546
Improved Fourier coefficients for maps using phases from partial structures with errorsQ56877556
Characterization of Two Adhesins of Bordetella pertussis for Human Ciliated Respiratory-Epithelial CellsQ59647772
Nicotinic acetylcholine receptor at 9 A resolution.Q64907739
Surface, subunit interfaces and interior of oligomeric proteinsQ68014868
Pertussis toxin S1 mutant with reduced enzyme activity and a conserved protective epitopeQ69043389
Identification of an active-site residue in subunit S1 of pertussis toxin by photocrosslinking to NADQ69638212
Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplicationQ24628759
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Structure of a C-type mannose-binding protein complexed with an oligosaccharideQ27642164
Structure of the Calcium-Dependent Lectin Domain from a Rat Mannose-Binding Protein Determined by MAD PhasingQ27643496
Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coliQ27644365
2.2 A resolution structure analysis of two refined N-acetylneuraminyl-lactose--wheat germ agglutinin isolectin complexesQ27677150
Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxinQ27732145
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical featuresQ27860675
Stereochemical quality of protein structure coordinatesQ27860874
Crystallographic R factor refinement by molecular dynamicsQ27860942
The crystal structure of diphtheria toxinQ28250331
Pertussis toxin gene: nucleotide sequence and genetic organizationQ28303347
OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequencesQ29620102
ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxinQ30403764
Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolutionQ30449676
Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activityQ33654379
Identification of amino acid residues essential for the enzymatic activities of pertussis toxinQ33852277
Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B modelQ34708294
Neurological complications of pertussis inoculationQ35151235
Site-specific alterations in the B oligomer that affect receptor-binding activities and mitogenicity of pertussis toxinQ36361184
Pertussis toxin has eukaryotic-like carbohydrate recognition domainsQ36759213
Binding of pertussis toxin to eucaryotic cells and glycoproteinsQ37004913
Inhibition of pertussis toxin binding to model receptors by antipeptide antibodies directed at an antigenic domain of the S2 subunitQ37007066
Pertussis vaccine and injury to the brainQ37928750
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcrystal structureQ895901
P304page(s)45-57
P577publication date1994-01-15
P1433published inStructureQ15709970
P1476titleThe crystal structure of pertussis toxin
P478volume2

Reverse relations

cites work (P2860)
Q35155875AB toxins: a paradigm switch from deadly to desirable
Q33927939AB(5) toxins: structures and inhibitor design
Q40694140AB5 ADP-ribosylating toxins: comparative anatomy and physiology
Q34407508ADP-ribosyltransferases: plastic tools for inactivating protein and small molecular weight targets.
Q37065008Ab initio phasing by molecular averaging in real space with new criteria: application to structure determination of a betanodavirus
Q59067615Acetylcholine receptor channel imaged in the open state
Q35398012Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(DL-lactide-co-glycolide) microspheres
Q33886834Aerolysin and pertussis toxin share a common receptor-binding domain
Q92647481Alternate subunit assembly diversifies the function of a bacterial toxin
Q43660256An abundance of bacterial ADP-ribosyltransferases--implications for the origin of exotoxins and their human homologues
Q39826142Analysis of proteins encoded by the ptx and ptl genes of Bordetella bronchiseptica and Bordetella parapertussis
Q40705587Analysis of relative levels of production of pertussis toxin subunits and Ptl proteins in Bordetella pertussis
Q40015199Analysis of subassemblies of pertussis toxin subunits in vivo and their interaction with the ptl transport apparatus
Q49167254Analysis of the catalytic site of the actin ADP-ribosylating Clostridium perfringens iota toxin.
Q39473894Antibacterial agents and release of periplasmic pertussis toxin from Bordetella pertussis
Q35780814Assignment of functional domains involved in ADP-ribosylation and B-oligomer binding within the carboxyl terminus of the S1 subunit of pertussis toxin
Q24653980Bacterial toxins: friends or foes?
Q24672930Barrel structures in proteins: automatic identification and classification including a sequence analysis of TIM barrels
Q24562788Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins
Q33536554Biochemistry of type IV secretion
Q33996430Biological and biochemical characterization of variant A subunits of cholera toxin constructed by site-directed mutagenesis
Q34383541Bordetella pertussis pathogenesis: current and future challenges
Q52803001Carbohydrate inhibitors of cholera toxin.
Q30877920Characterization of a key neutralizing epitope on pertussis toxin recognized by monoclonal antibody 1B7.
Q24650467Characterization of a streptococcal cholesterol-dependent cytolysin with a lewis y and b specific lectin domain
Q45721002Characterization of the carbohydrate binding and ADP-ribosyltransferase activities of chemically detoxified pertussis toxins
Q24653990Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase
Q34263384Clostridium and bacillus binary enterotoxins: bad for the bowels, and eukaryotic being.
Q52540113Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins.
Q24643808Common themes in microbial pathogenicity revisited
Q72411060Conservation of a common motif in enzymes catalyzing ADP-ribose transfer. Identification of domains in mammalian transferases
Q36226458Contribution of pertussis toxin to the pathogenesis of pertussis disease
Q35817188Crystal Structures of a Piscine Betanodavirus: Mechanisms of Capsid Assembly and Viral Infection
Q27733378Crystal structure of a new heat-labile enterotoxin, LT-IIb
Q27733160Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation
Q27627715Crystal structure of the iron-dependent regulator from Mycobacterium tuberculosis at 2.0-A resolution reveals the Src homology domain 3-like fold and metal binding function of the third domain
Q27745853Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin
Q37386934DSB proteins and bacterial pathogenicity.
Q61804918Development and implementation of standardized method for detecting immunogenicity of acellular pertussis vaccines in Korea
Q27649159Draft Crystal Structure of the Vault Shell at 9-Å Resolution
Q39654926DsbA and DsbC are required for secretion of pertussis toxin by Bordetella pertussis
Q37964769Endoplasmic reticulum-dependent redox reactions control endoplasmic reticulum-associated degradation and pathogen entry
Q41832901Evading the proteasome: absence of lysine residues contributes to pertussis toxin activity by evasion of proteasome degradation
Q34758995Expression of a C terminally truncated form of pertussis toxin S1 subunit effectively induces protection against pertussis toxin following DNA-based immunization.
Q34633613G(i/o) protein-dependent and -independent actions of Pertussis Toxin (PTX).
Q51807800Genetic exchange of the S2 and S3 subunits in pertussis toxin.
Q33743658Genetically derived toxoids for use as vaccines and adjuvants
Q38245652Genetically detoxified pertussis toxin (PT-9K/129G): implications for immunization and vaccines.
Q98222196Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity
Q40700459Genome Structural Diversity among 31 Bordetella pertussis Isolates from Two Recent U.S. Whooping Cough Statewide Epidemics
Q39823489Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies
Q89922274Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring
Q45018408How bacterial ADP-ribosylating toxins recognize substrates
Q34370945Human antibody response to the B oligomer of pertussis toxin
Q38355167Identification of Regulatory Domains in ADP-ribosyltransferase-1 That Determine Transferase and NAD Glycohydrolase Activities
Q41366656Identification of binding proteins for pertussis toxin on pancreatic beta cell-derived insulin-secreting cells
Q39537670Importance of holotoxin assembly in Ptl-mediated secretion of pertussis toxin from Bordetella pertussis
Q30176276Interaction with a lipid membrane: a key step in bacterial toxins virulence.
Q38329612Interaction with type IV pili induces structural changes in the bacterial outer membrane secretin PilQ.
Q92209807Intracellular Trafficking and Translocation of Pertussis Toxin
Q39509568Intracellular delivery of a cytolytic T-lymphocyte epitope peptide by pertussis toxin to major histocompatibility complex class I without involvement of the cytosolic class I antigen processing pathway
Q49714209Intracellular disassembly and activity of pertussis toxin require interaction with ATP.
Q34756931Intramolecular dimerization is required for the chlamydia-secreted protease CPAF to degrade host transcriptional factors
Q38358628Investigating pertussis toxin and its impact on vaccination
Q40399126Lectin domains in the toxin of Bordetella pertussis: selectin mimicry linked to microbial pathogenesis.
Q37036006Mechanism and Function of Type IV Secretion During Infection of the Human Host
Q39654215Membrane localization of the S1 subunit of pertussis toxin in Bordetella pertussis and implications for pertussis toxin secretion
Q77466560Molecular basis of vaccination
Q41214669Mono-ADP-ribosylation: a reversible posttranslational modification of proteins.
Q39514520Mutations in the S1 subunit of pertussis toxin that affect secretion
Q81299918Noncrystallographic symmetry averaging in phase refinement and extension
Q32138722Not your average density.
Q38229329Novel bacterial ADP-ribosylating toxins: structure and function
Q73389306Novel configurations of high molecular weight species of the pertussis toxin vaccine component
Q47687598Novel molecular biology approaches to acellular vaccines.
Q36739680Order-disorder-order transitions mediate the activation of cholera toxin.
Q34875804Organization of an activator-bound RNA polymerase holoenzyme
Q30368988Overview of protein structural and functional folds.
Q36669806Pattern recognition receptors in companion and farm animals - the key to unlocking the door to animal disease?
Q24670399Pertussis Toxin Plays an Early Role in Respiratory Tract Colonization byBordetella pertussis
Q24602050Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools
Q28482165Pertussis toxin, an inhibitor of G(αi) PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytes
Q35391228Pertussis toxin-mediated ADP-ribosylation of target proteins in Chinese hamster ovary cells involves a vesicle trafficking mechanism
Q30251684Pertussis: Microbiology, Disease, Treatment, and Prevention
Q55220191Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin.
Q27656496Physical Interactions between Mcm10, DNA, and DNA Polymerase
Q39255935Physicochemically stable cholera toxin B subunit pentamer created by peripheral molecular constraints imposed by de novo-introduced intersubunit disulfide crosslinks.
Q72798665Predicted secondary structure of the 20 S proteasome and model structure of the putative peptide channel
Q41930067Preferential processing of the S1 subunit of pertussis toxin that is bound to eukaryotic cells
Q30464125Progress in high resolution atomic force microscopy in biology
Q65001074Protein Toxins That Utilize Gangliosides as Host Receptors.
Q40629288Proteins with a ring
Q24795540Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells
Q42063250Purification and three-dimensional electron microscopy structure of the Neisseria meningitidis type IV pilus biogenesis protein PilG.
Q37077527Quantum crystallographic charge density of urea.
Q30677297Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing.
Q33596979Recombinant Mycobacterium bovis BCG expressing pertussis toxin subunit S1 induces protection against an intracerebral challenge with live Bordetella pertussis in mice
Q38251141Recombinant bacillus Calmette-Guérin in urothelial bladder cancer immunotherapy: current strategies
Q39730320Reduced glutathione is required for pertussis toxin secretion by Bordetella pertussis
Q24675451Refined structure of dimeric diphtheria toxin at 2.0 A resolution
Q24673456Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity
Q41878198Requirements for assembly of PtlH with the pertussis toxin transporter apparatus of Bordetella pertussis
Q28264987Retrograde transport of pertussis toxin in the mammalian cell
Q39519875Reversal of the CD4(+)/CD8(+) T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified, water-soluble S3-S4 dimer of pertussis toxin
Q27650104Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr
Q38298647Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins
Q42060384Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin
Q28387185Shiga-like toxin B subunit of Escherichia coli as scaffold for high-avidity display of anti-immunocomplex peptides
Q27318916Single Amino Acid Polymorphisms of Pertussis Toxin Subunit S2 (PtxB) Affect Protein Function
Q54598155Site-directed mutagenic alteration of potential active-site residues of the A subunit of Escherichia coli heat-labile enterotoxin. Evidence for a catalytic role for glutamic acid 112.
Q34396196Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration
Q35196678Stable expression of pertussis toxin in Bordetella bronchiseptica under the control of a tightly regulated promoter.
Q27679027Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin
Q37475188Structure determination of a human virus by the combination of cryo-EM and X-ray crystallography
Q35549284Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae
Q27729810Structure of a pertussis toxin-sugar complex as a model for receptor binding
Q27733281Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken
Q27643107Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
Q40284359Structure of the transporter associated with antigen processing trapped by herpes simplex virus
Q40153039Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins
Q30449521Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein
Q38307893The 70-kilodalton pertussis toxin-binding protein in Jurkat cells.
Q39181842The Molecular Basis of Toxins' Interactions with Intracellular Signaling via Discrete Portals
Q34398250The Rho-ADP-ribosylating C3 exoenzyme from Clostridium botulinum and related C3-like transferases
Q95355784The Role of Typhoid Toxin in Salmonella Typhi Virulence
Q27674368The Structural Basis for the Integrity of Adenovirus Ad3 Dodecahedron
Q37119104The chromosomal nature of LT-II enterotoxins solved: a lambdoid prophage encodes both LT-II and one of two novel pertussis-toxin-like toxin family members in type II enterotoxigenic Escherichia coli.
Q27729698The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin
Q34058617The family of bacterial ADP-ribosylating exotoxins
Q27617515The high-resolution crystal structure of the molybdate-dependent transcriptional regulator (ModE) from Escherichia coli: a novel combination of domain folds
Q37899279The ins and outs of pertussis toxin
Q24642842The pertussis toxin S1 subunit is a thermally unstable protein susceptible to degradation by the 20S proteasome
Q37138328The restriction enzyme SgrAI: structure solution via combination of poor MIRAS and MR phases
Q27734665The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold
Q27653859The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria
Q34307587The versatile bacterial type IV secretion systems
Q38129761The virulence factors of Bordetella pertussis: talented modulators of host immune response.
Q37424978Thermal Unfolding of the Pertussis Toxin S1 Subunit Facilitates Toxin Translocation to the Cytosol by the Mechanism of Endoplasmic Reticulum-Associated Degradation
Q31989458Topological mimicry and epitope duplication in the guanylyl cyclase C receptor
Q34426721Toxin instability and its role in toxin translocation from the endoplasmic reticulum to the cytosol
Q37954284Toxins-useful biochemical tools for leukocyte research
Q43765382Unbinding forces of single pertussis toxin-antibody complexes measured by atomic force spectroscopy correlate with their dissociation rates determined by surface plasmon resonance
Q46848764Unraveling the structures and modes of action of bacterial toxins
Q35695002Unveiling molecular scaffolds of the type IV secretion system
Q34004892Use of pertussis toxin encoded by ptx genes from Bordetella bronchiseptica to model the effects of antigenic drift of pertussis toxin on antibody neutralization
Q38758699Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation

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