Mechanism and Function of Type IV Secretion During Infection of the Human Host

scientific article published on June 2016

Mechanism and Function of Type IV Secretion During Infection of the Human Host is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1128/MICROBIOLSPEC.VMBF-0024-2015
P932PMC publication ID4920089
P698PubMed publication ID27337453

P2093author name stringMinny Bhatty
Peter J Christie
Christian Gonzalez-Rivera
P2860cites workEvaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosisQ61052034
Formation of a fibrous structure on the surface of Legionella pneumophila associated with exposure of DotH and DotO proteins after intracellular growthQ73341429
Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8Q77748414
Q fever endocarditisQ83168861
Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoaQ21131567
Comparison of the genomes of two Xanthomonas pathogens with differing host specificitiesQ22122346
The genome sequence of Rickettsia prowazekii and the origin of mitochondriaQ22122428
Molecular characterization of an operon required for pertussis toxin secretionQ24563213
Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilumQ24604079
Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplicationQ24628759
Structure of the outer membrane complex of a type IV secretion systemQ24654218
Host cell-free growth of the Q fever bacterium Coxiella burnetiiQ24656253
Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis inductionQ27315871
A translocated effector required for Bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectorsQ27325159
Crystal Structure of Legionella DotD: Insights into the Relationship between Type IVB and Type II/III Secretion SystemsQ27665064
A Component of the Xanthomonadaceae Type IV Secretion System Combines a VirB7 Motif with a N0 Domain Found in Outer Membrane Transport ProteinsQ27667877
Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphataseQ27671332
Structure of a bacterial type IV secretion core complex at subnanometre resolutionQ27676893
Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systemsQ27678344
Identification and Structural Characterization of a Legionella Phosphoinositide PhosphataseQ27679029
Anaplasma phagocytophilum and Ehrlichia chaffeensis type IV secretion and Ank proteins.Q27692130
Bacterial killing via a type IV secretion systemQ27698110
The crystal structure of pertussis toxinQ27730897
A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomesQ40754890
A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suisQ40925092
Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cellsQ41533814
Novel export control of a Legionella Dot/Icm substrate is mediated by dual, independent signal sequencesQ41548353
Enterococcus faecalis pCF10-encoded surface proteins PrgA, PrgB (aggregation substance) and PrgC contribute to plasmid transfer, biofilm formation and virulenceQ41645090
Synergistic effects in mixed Escherichia coli biofilms: conjugative plasmid transfer drives biofilm expansionQ41672690
Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF.Q41819572
Definition of a bacterial type IV secretion pathway for a DNA substrateQ41853646
The coupling protein Cagbeta and its interaction partner CagZ are required for type IV secretion of the Helicobacter pylori CagA proteinQ41854693
Antiapoptotic activity of Coxiella burnetii effector protein AnkG is controlled by p32-dependent traffickingQ41907006
Evolution of conjugation and type IV secretion systemsQ41992246
Functional and topological characterization of novel components of the comB DNA transformation competence system in Helicobacter pyloriQ42037391
The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugationQ42155652
A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa.Q42175516
Identification of new protein-protein interactions involving the products of the chromosome- and plasmid-encoded type IV secretion loci of the phytopathogen Xanthomonas axonopodis pv. citriQ42651061
Natural transformation competence in Helicobacter pylori is mediated by the basic components of a type IV secretion systemQ42656308
Analyses of the cag pathogenicity island of Helicobacter pyloriQ42677857
Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.Q42819835
A variable genetic island specific for Neisseria gonorrhoeae is involved in providing DNA for natural transformation and is found more often in disseminated infection isolatesQ43674788
Structural definition on the surface of Helicobacter pylori type IV secretion apparatusQ44461615
Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infectionQ44930480
Interaction of the virulence protein VirF of Agrobacterium tumefaciens with plant homologs of the yeast Skp1 proteinQ45269128
Domain organization of Legionella effector SetA.Q45717465
Conservation of the Type IV secretion system throughout Wolbachia evolutionQ45885108
Effects of tetracycline on the filarial worms Brugia pahangi and Dirofilaria immitis and their bacterial endosymbionts WolbachiaQ45888257
Host cell interactome of tyrosine-phosphorylated bacterial proteinsQ46044003
The VirB5 protein localizes to the T-pilus tips in Agrobacterium tumefaciensQ46920770
Conjugative transfer by the virulence system of Legionella pneumophilaQ48040136
Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factorsQ48076322
Neisseria gonorrhoeae secretes chromosomal DNA via a novel type IV secretion systemQ48147768
Combined action of the type IV secretion effector proteins BepC and BepF promotes invasome formation of Bartonella henselae on endothelial and epithelial cells.Q50537803
A C-terminal translocation signal is necessary, but not sufficient for type IV secretion of the Helicobacter pylori CagA protein.Q50739945
Differential expression of VirB9 and VirB6 during the life cycle of Anaplasma phagocytophilum in human leucocytes is associated with differential binding and avoidance of lysosome pathway.Q52026380
Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuoleQ57042065
Functional interactions between type IV secretion systems involved in DNA transfer and virulenceQ59721124
Host-mediated post-translational prenylation of novel dot/icm-translocated effectors of legionella pneumophilaQ35028893
Orientia tsutsugamushi ankyrin repeat-containing protein family members are Type 1 secretion system substrates that traffic to the host cell endoplasmic reticulumQ35042355
Bioinformatic and mass spectrometry identification of Anaplasma phagocytophilum proteins translocated into host cell nucleiQ35056830
Type IV transporters of pathogenic bacteriaQ35077180
Helicobacter pylori CagA--a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteinsQ35090018
GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2.Q35094135
Secretome of obligate intracellular RickettsiaQ35132653
The Gonococcal Genetic Island and Type IV Secretion in the Pathogenic NeisseriaQ35155296
Anchors for effectors: subversion of phosphoinositide lipids by legionella.Q35155317
Advances in genetic manipulation of obligate intracellular bacterial pathogensQ35155325
Modulation of the host innate immune and inflammatory response by translocated bacterial proteinsQ28083042
Oncogenic mechanisms of the Helicobacter pylori CagA proteinQ28280246
IcmS-dependent translocation of SdeA into macrophages by the Legionella pneumophila type IV secretion systemQ28485634
Type VI secretion delivers bacteriolytic effectors to target cellsQ28493220
Identification of OmpA, a Coxiella burnetii protein involved in host cell invasion, by multi-phenotypic high-content screeningQ28541251
Biology of WolbachiaQ29615110
Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotesQ29618146
Helicobacter pylori infection and the risk of gastric carcinomaQ29618446
Composite system mediates two-step DNA uptake into Helicobacter pyloriQ30493221
A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formationQ30495550
Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humansQ30530885
Structure of the type IV secretion system in different strains of Anaplasma phagocytophilumQ30533216
c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifsQ30829845
Positive charge is an important feature of the C-terminal transport signal of the VirB/D4-translocated proteins of Agrobacterium.Q30854480
The gene encoding the 17-kDa antigen of Bartonella henselae is located within a cluster of genes homologous to the virB virulence operonQ30883995
Biological diversity of prokaryotic type IV secretion systems.Q30927042
Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent mannerQ30973380
Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatusQ30981200
A bacterial conjugation machinery recruited for pathogenesisQ31155054
A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion systemQ33187523
A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolatesQ33279533
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA proteinQ33292154
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sitesQ33292319
Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1.Q33319274
An anomalous type IV secretion system in Rickettsia is evolutionarily conservedQ33417268
Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector.Q33545239
Identification of genes required for chronic persistence of Brucella abortus in miceQ33597577
The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytesQ33604841
Helicobacter pylori virulence and genetic geographyQ33639332
Aggregation and binding substances enhance pathogenicity in rabbit models of Enterococcus faecalis endocarditisQ33748332
A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cellsQ33756268
A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cellsQ33756497
Comprehensive identification of protein substrates of the Dot/Icm type IV transporter of Legionella pneumophilaQ33847063
The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replicationQ33921269
Dot/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophagesQ35187016
Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae.Q35198136
A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesisQ35216620
Functional analysis of the Gonococcal Genetic Island of Neisseria gonorrhoeaeQ35360939
Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactionsQ35465763
Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoproteinQ35574969
An activation domain of plasmid R1 TraI protein delineates stages of gene transfer initiationQ35633340
A Rickettsia genome overrun by mobile genetic elements provides insight into the acquisition of genes characteristic of an obligate intracellular lifestyleQ35668080
Asymptomatic transmission and the resurgence of Bordetella pertussisQ35672136
Coupling factors in macromolecular type-IV secretion machineriesQ35768662
The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genesQ35808855
Molecular and cellular basis of bartonella pathogenesisQ35919857
Surface-exposed proteins of Ehrlichia chaffeensisQ35949683
Two systems for targeted gene deletion in Coxiella burnetiiQ36017865
Ehrlichia type IV secretion effector ECH0825 is translocated to mitochondria and curbs ROS and apoptosis by upregulating host MnSODQ36020043
Bacterial effector binds host cell adenylyl cyclase to potentiate Gαs-dependent cAMP productionQ36066417
Natural history and pathophysiology of Q feverQ36081084
Tyrosine-phosphorylated bacterial effector proteins: the enemies withinQ36229117
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane proteinQ36295605
Identification of novel surface proteins of Anaplasma phagocytophilum by affinity purification and proteomicsQ36314896
Invasion and persistent intracellular colonization of erythrocytes. A unique parasitic strategy of the emerging pathogen BartonellaQ36369332
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulumQ36371637
Plasticity of repetitive DNA sequences within a bacterial (Type IV) secretion system componentQ36371857
Type IV secretion systems and their effectors in bacterial pathogenesis.Q36418304
VirB12 is a serological marker of Brucella infection in experimental and natural hostsQ36452324
Natural competence promotes Helicobacter pylori chronic infectionQ36506077
Genetic and functional characterization of the type IV secretion system in WolbachiaQ36747848
Sensing of bacterial type IV secretion via the unfolded protein responseQ36760509
The highly repetitive region of the Helicobacter pylori CagY protein comprises tandem arrays of an alpha-helical repeat moduleQ36967932
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functionsQ36989053
Binding of pertussis toxin to eucaryotic cells and glycoproteinsQ37004913
Infection-associated type IV secretion systems of Bartonella and their diverse roles in host cell interactionQ37029515
Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuolesQ37033432
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane traffickingQ33935172
Natural conjugative plasmids induce bacterial biofilm developmentQ33953756
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cellsQ33987714
The Agrobacterium tumefaciens chaperone-like protein, VirE1, interacts with VirE2 at domains required for single-stranded DNA binding and cooperative interaction.Q33993163
The repertoire of ICE in prokaryotes underscores the unity, diversity, and ubiquity of conjugationQ34005318
The Brucella suis virB operon is induced intracellularly in macrophagesQ34010148
Genetic competence in Helicobacter pylori: mechanisms and biological implicationsQ34015688
Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interfaceQ34016256
Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector of Legionella pneumophilaQ34044433
Comparative genomic analysis of Streptococcus suis reveals significant genomic diversity among different serotypesQ34057381
Genes required for assembly of pili associated with the Helicobacter pylori cag type IV secretion systemQ34058916
Native structure of a type IV secretion system core complex essential for Legionella pathogenesisQ34060526
Identification of Anaplasma marginale type IV secretion system effector proteinsQ34091037
Characterization and transcriptional analysis of gene clusters for a type IV secretion machinery in human granulocytic and monocytic ehrlichiosis agentsQ34120741
The Legionella pneumophila effector VipA is an actin nucleator that alters host cell organelle trafficking.Q34181343
Interactions of the human pathogenic Brucella species with their hostsQ34218409
Recent advances in the structural and molecular biology of type IV secretion systemsQ34276673
Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector proteinQ34279193
Identification of novel Coxiella burnetii Icm/Dot effectors and genetic analysis of their involvement in modulating a mitogen-activated protein kinase pathwayQ34298317
The versatile bacterial type IV secretion systemsQ34307587
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity islandQ34359740
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systemsQ34368266
Bordetella pertussis pathogenesis: current and future challengesQ34383541
Structure of a type IV secretion systemQ34412183
The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates.Q34426447
Type-IVC secretion system: a novel subclass of type IV secretion system (T4SS) common existing in gram-positive genus StreptococcusQ34441405
Signature-tagged mutagenesis: technical advances in a negative selection method for virulence gene identificationQ34446340
Biogenesis, architecture, and function of bacterial type IV secretion systemsQ34449723
Type IVB secretion by intracellular pathogensQ34557143
Functional plasticity in the type IV secretion system of Helicobacter pyloriQ34611151
Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetiiQ34611714
Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B modelQ34708294
Structure of a type IV secretion system core complex.Q34917985
Brucella modulates secretory trafficking via multiple type IV secretion effector proteins.Q34945507
The natural alternative: protozoa as cellular models for Legionella infectionQ38156244
Mechanism and structure of the bacterial type IV secretion systemsQ38175753
The many faces of Fic: structural and functional aspects of Fic enzymesQ38186245
Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesisQ38195961
Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targetsQ38206869
Towards an integrated model of bacterial conjugationQ38242996
New insights into the role of Bartonella effector proteins in pathogenesisQ38280761
Legionella pneumophila: homeward bound away from the phagosomeQ38280765
Coxiella burnetii: turning hostility into a homeQ38366481
Formation of a pathogen vacuole according to Legionella pneumophila: how to kill one bird with many stones.Q38436575
Chromatin-bound bacterial effector ankyrin A recruits histone deacetylase 1 and modifies host gene expression.Q38872601
Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector.Q38930726
A translocation motif in relaxase TrwC specifically affects recruitment by its conjugative type IV secretion systemQ39101676
The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication.Q39123373
The Coxiella burnetii type IV secretion system substrate CaeB inhibits intrinsic apoptosis at the mitochondrial levelQ39249446
A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system.Q39252274
The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion.Q39408924
Importance of holotoxin assembly in Ptl-mediated secretion of pertussis toxin from Bordetella pertussisQ39537670
Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2.Q39557059
Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transferQ39614711
Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoproteinQ39703063
The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication.Q39722305
A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria.Q39852238
Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.Q39903653
Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion systemQ39914768
Isolation of protozoa from water associated with a legionellosis outbreak and demonstration of intracellular multiplication of Legionella pneumophila.Q40052967
Helicobacter exploits integrin for type IV secretion and kinase activationQ40066287
Host cell-dependent secretion and translocation of the LepA and LepB effectors of Legionella pneumophila.Q40157064
Anaplasma phagocytophilum AnkA is tyrosine-phosphorylated at EPIYA motifs and recruits SHP-1 during early infectionQ40179612
Interaction with CagF is required for translocation of CagA into the host via the Helicobacter pylori type IV secretion systemQ40337656
Adaptation of a conjugal transfer system for the export of pathogenic macromoleculesQ40721209
Bartonella and Brucella--weapons and strategies for stealth attackQ37040231
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factorsQ37047617
Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus CoxiellaQ37075501
Identification of Coxiella burnetii type IV secretion substrates required for intracellular replication and Coxiella-containing vacuole formationQ37124987
Coxiella type IV secretion and cellular microbiologyQ37162198
Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogenQ37190720
Silencing of host cell CYBB gene expression by the nuclear effector AnkA of the intracellular pathogen Anaplasma phagocytophilumQ37204532
The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretionQ37232712
Genomic islands: tools of bacterial horizontal gene transfer and evolutionQ37248338
The expanding bacterial type IV secretion lexiconQ37275377
Common themes in the design and function of bacterial effectorsQ37312444
Bartonella henselae: subversion of vascular endothelial cell functions by translocated bacterial effector proteinsQ37325998
The Legionella pneumophila replication vacuole: making a cosy niche inside host cellsQ37326393
Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesisQ37377350
Bacterial type IV secretion systems in human diseaseQ37445142
PrgK, a multidomain peptidoglycan hydrolase, is essential for conjugative transfer of the pheromone-responsive plasmid pCF10.Q37545675
Temporal analysis of Coxiella burnetii morphological differentiationQ37583353
Functional diversity of ankyrin repeats in microbial proteinsQ37644958
VipD is a Rab5-activated phospholipase A1 that protects Legionella pneumophila from endosomal fusion.Q37674312
Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cellsQ37725654
The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesisQ37765917
Modulation of host cell function by Legionella pneumophila type IV effectorsQ37798551
Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatusQ37847237
Subversion of host cell signaling by Orientia tsutsugamushiQ37860538
The ins and outs of pertussis toxinQ37899279
Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria.Q37899756
Intracellular Rickettsiales: Insights into manipulators of eukaryotic cellsQ37901702
ThANKs for the repeat: Intracellular pathogens exploit a common eukaryotic domainQ37978864
Internal affairs: investigating the Brucella intracellular lifestyleQ37988968
Bartonella entry mechanisms into mammalian host cellsQ38004072
Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and functionQ38006509
New perspectives into bacterial DNA transfer to human cellsQ38022822
Bacterial EPIYA effectors--where do they come from? What are they? Where are they going?Q38050868
Brucella T4SS: the VIP pass inside host cellsQ38073982
Horizontal gene transfer in human pathogensQ38122176
Modulation of the ubiquitination machinery by Legionella.Q38126841
P433issue3
P407language of work or nameEnglishQ1860
P577publication date2016-06-01
P1433published inMicrobiology SpectrumQ27725717
P1476titleMechanism and Function of Type IV Secretion During Infection of the Human Host
P478volume4

Reverse relations

cites work (P2860)
Q55519111A case series of primary cutaneous coccidioidomycosis after a record-breaking rainy season.
Q88764557A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel
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Q92526712Bacteria-Killing Type IV Secretion Systems
Q64082357Biological and Structural Diversity of Type IV Secretion Systems
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Q37738564Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella
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Q64056350Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System
Q92999216Stenotrophomonas maltophilia Encodes a VirB/VirD4 Type IV Secretion System That Modulates Apoptosis in Human Cells and Promotes Competition against Heterologous Bacteria, Including Pseudomonas aeruginosa
Q48302572Substrate translocation involves specific lysine residues of the central channel of the conjugative coupling protein TrwB.
Q57751771Two pKM101-encoded proteins, the pilus-tip protein TraC and Pep, assemble on the Escherichia coli cell surface as adhesins required for efficient conjugative DNA transfer

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