Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

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Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites is …
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scholarly articleQ13442814

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P819ADS bibcode2002PNAS...9914428H
P356DOI10.1073/PNAS.222375399
P8608Fatcat IDrelease_luhvpbaox5fbpbextxm6ukmk3m
P932PMC publication ID137900
P698PubMed publication ID12391297
P5875ResearchGate publication ID11071599

P50authorRyouhei TsutsumiQ56015556
Masanori HatakeyamaQ90553202
P2093author name stringMasahiro Asaka
Takeshi Azuma
Akiko Fujita
Hideaki Higashi
Shiho Yamazaki
P2860cites workInduction of host signal transduction pathways by Helicobacter pyloriQ34741347
Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocationQ35015052
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factorsQ37047617
Analyses of the cag pathogenicity island of Helicobacter pyloriQ42677857
Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.Q42819835
Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cellsQ43808787
Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains.Q44755796
Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancerQ48019587
Molecular epidemiology of Helicobacter pylori: separation of H. pylori from East Asian and non-Asian countriesQ57216315
Relationship between the cagA 3' repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pHQ57216597
Allelic variation in the cagA gene of Helicobacter pylori obtained from Korea compared to the United StatesQ57217616
Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domainsQ71673010
Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomachQ72220074
Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbilsQ77391803
Patients younger than 40 years with gastric carcinoma: Helicobacter pylori genotype and associated gastritis phenotypeQ77900398
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pyloriQ22122443
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1Q24305352
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptorQ24310840
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2Q24314461
Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcerQ24562562
Crystal structure of the tyrosine phosphatase SHP-2Q27748898
Helicobacter pylori infection induces gastric cancer in mongolian gerbilsQ28280923
Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pyloriQ28776428
Helicobacter pylori infection and the development of gastric cancerQ29615341
c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifsQ30829845
Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatusQ30981200
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificitiesQ31096727
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA proteinQ33292154
Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infectionQ33617838
Helicobacter pylori infection and gastric cancer: systematic review of the epidemiological studiesQ33670744
Variants of the 3' region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseasesQ33675894
Differences in genotypes of Helicobacter pylori from different human populationsQ33994164
Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cellsQ34507295
Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretionQ34507324
Helicobacter pylori and atrophic gastritis: importance of the cagA statusQ34718764
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectHelicobacter pyloriQ180556
phosphorylationQ242736
Helicobacter pylori infectious diseaseQ4497153
P304page(s)14428-14433
P577publication date2002-10-21
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleBiological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
P478volume99

Reverse relations

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