CagA Phosphorylation in Helicobacter pylori-Infected B Cells Is Mediated by the Nonreceptor Tyrosine Kinases of the Src and Abl Families

scientific article published on 05 July 2016

CagA Phosphorylation in Helicobacter pylori-Infected B Cells Is Mediated by the Nonreceptor Tyrosine Kinases of the Src and Abl Families is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.00349-16
P932PMC publication ID4995908
P698PubMed publication ID27382024

P50authorGernot PosseltQ41182113
Silja WesslerQ37841647
P2093author name stringPeter Hammerl
Linda M Krisch
P2860cites workc-Abl kinase regulates the protein binding activity of c-CrkQ24595669
Helicobacter exploits integrin for type IV secretion and kinase activationQ40066287
Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scatteringQ40149736
Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motilityQ40198121
The Helicobacter pylori virulence factor CagA promotes Erk1/2-mediated Bad phosphorylation in lymphocytes: a mechanism of CagA-inhibited lymphocyte apoptosisQ40202131
Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinaseQ40687950
Tyrosine phosphorylation patterns and size modification of the Helicobacter pylori CagA protein after translocation into gastric epithelial cellsQ40772158
Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.Q42819835
MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformationQ42820324
Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphomaQ44653675
Host cell interactome of tyrosine-phosphorylated bacterial proteinsQ46044003
The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genesQ46542604
Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported proteinQ48083694
Gastric non-Hodgkin lymphomas of mucosa-associated lymphoid tissue are not associated with more aggressive Helicobacter pylori strains as identified by CagAQ71802082
MALT-type lymphoma of the stomach is associated with Helicobacter pylori strains expressing the CagA proteinQ73309459
Helicobacter pylori persistence: biology and diseaseQ24618823
Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pyloriQ28249235
Role of ABL family kinases in cancer: from leukaemia to solid tumoursQ28396643
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activationQ29617586
c-Abl tyrosine kinase and inhibition by the cancer drug imatinib (Gleevec/STI-571).Q30157972
An intramolecular SH3-domain interaction regulates c-Abl activityQ30176270
Identification of a tyrosine-phosphorylated 35 kDa carboxy-terminal fragment (p35CagA) of the Helicobacter pylori CagA protein in phagocytic cells: processing or breakage?Q30756816
c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifsQ30829845
Interaction of Helicobacter pylori with professional phagocytes: role of the cag pathogenicity island and translocation, phosphorylation and processing of CagA.Q32026818
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA proteinQ33292154
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sitesQ33292319
Helicobacter pylori and gastric cancer: factors that modulate disease riskQ34189885
Gastric MALT lymphoma: from aetiology to treatmentQ34569977
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dQ34573116
Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesisQ34761945
Complex cellular responses of Helicobacter pylori-colonized gastric adenocarcinoma cellsQ35075817
The biological model of gastric carcinogenesisQ35727403
c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strainsQ35858125
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouseQ36459009
Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists.Q36584820
Detection of the Helicobacter pylori CagA protein in gastric mucosa-associated lymphoid tissue lymphoma cells: clinical and biological significanceQ37061428
Molecular mechanisms of epithelial-barrier disruption by Helicobacter pyloriQ37213499
The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesisQ37765917
Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talkQ37808572
Abl family of tyrosine kinases and microbial pathogenesisQ37825706
Regulation of the actin cytoskeleton in Helicobacter pylori-induced migration and invasive growth of gastric epithelial cellsQ37951691
The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesisQ38149990
Helicobacter pylori and mucosa-associated lymphoid tissue: what's new.Q38169632
Role of Helicobacter pylori virulence factor cytotoxin-associated gene A in gastric mucosa-associated lymphoid tissue lymphomaQ38173352
Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric lymphomagenesisQ39567503
cag+ Helicobacter pylori induces homotypic aggregation of macrophage-like cells by up-regulation and recruitment of intracellular adhesion molecule 1 to the cell surface.Q39655916
Translocation of Helicobacter pylori CagA into Human B lymphocytes, the origin of mucosa-associated lymphoid tissue lymphomaQ39687130
The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivationQ39698949
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectHelicobacter pyloriQ180556
phosphorylationQ242736
P304page(s)2671-2680
P577publication date2016-07-05
P1433published inInfection and ImmunityQ6029193
P1476titleCagA Phosphorylation in Helicobacter pylori-Infected B Cells Is Mediated by the Nonreceptor Tyrosine Kinases of the Src and Abl Families
P478volume84

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cites work (P2860)
Q48143477A Drug Repositioning Approach Reveals that Streptococcus mutans Is Susceptible to a Diverse Range of Established Antimicrobials and Nonantibiotics.
Q52595435Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ.
Q41480432Creation and Initial Characterization of Isogenic Helicobacter pylori CagA EPIYA Variants Reveals Differential Activation of Host Cell Signaling Pathways
Q39252748From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases
Q61804902Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis
Q92433730Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study
Q37736423Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer.
Q52349005The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It.
Q39198532Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors
Q90722069Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer

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