A mutagenesis method for the addition and deletion of highly repetitive DNA regions: the paradigm of EPIYA motifs in the cagA gene of Helicobacter pylori

scientific article published on 27 November 2012

A mutagenesis method for the addition and deletion of highly repetitive DNA regions: the paradigm of EPIYA motifs in the cagA gene of Helicobacter pylori is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/HEL.12029
P8608Fatcat IDrelease_4kpveytpyndi5aowon23r7k4nq
P698PubMed publication ID23190444
P5875ResearchGate publication ID233797333

P50authorKonstantinos S PapadakosQ59696939
P2093author name stringAndreas F Mentis
Dionyssios N Sgouras
Ioanna S Sougleri
P2860cites workHelicobacter pylori persistence: biology and diseaseQ24618823
Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substratesQ24624540
Oncogenic mechanisms of the Helicobacter pylori CagA proteinQ28280246
A review of human carcinogens--Part B: biological agentsQ29615608
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sitesQ33292319
CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.Q33909465
Mutation frequency and biological cost of antibiotic resistance in Helicobacter pyloriQ33952076
Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretionQ34507324
Strategy to characterize the number and type of repeating EPIYA phosphorylation motifs in the carboxyl terminus of CagA protein in Helicobacter pylori clinical isolatesQ35690396
c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strainsQ35858125
Construction of isogenic urease-negative mutants of Helicobacter pylori by allelic exchangeQ36113400
Bacterial populations as perfect gases: genomic integrity and diversification tensions in Helicobacter pyloriQ36623687
Aflagellated mutants of Helicobacter pylori generated by genetic transformation of naturally competent strains using transposon shuttle mutagenesisQ36765027
Helicobacter pylori evolution and phenotypic diversification in a changing hostQ36823720
The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseasesQ37014743
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factorsQ37047617
CagA and VacA polymorphisms do not correlate with severity of histopathological lesions in Helicobacter pylori-infected Greek childrenQ37302167
The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesisQ37765917
A novel flow cytometric assay for quantitating adherence of Helicobacter pylori to gastric epithelial cellsQ38335391
Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammationQ39893265
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.Q40131894
Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA.Q40291840
Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activityQ40507004
Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori.Q40527352
DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprintingQ40534615
Functional and topological characterization of novel components of the comB DNA transformation competence system in Helicobacter pyloriQ42037391
Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transferQ42411236
Natural transformation competence in Helicobacter pylori is mediated by the basic components of a type IV secretion systemQ42656308
Natural competence for DNA transformation in Helicobacter pylori: identification and genetic characterization of the comB locusQ42680921
Helicobacter pylori induces NF-kappaB independent of CagA.Q42923135
Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequenceQ46931946
Evaluation of the homologous recombination in Helicobacter pyloriQ48137307
Response: strain-specific activation of NF-κB by Helicobacter pylori CagA.Q49279183
Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms.Q54533319
P433issue3
P921main subjectHelicobacter pyloriQ180556
P304page(s)229-241
P577publication date2012-11-27
P1433published inHelicobacterQ15756348
P1476titleA mutagenesis method for the addition and deletion of highly repetitive DNA regions: the paradigm of EPIYA motifs in the cagA gene of Helicobacter pylori
P478volume18

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cites work (P2860)
Q41480432Creation and Initial Characterization of Isogenic Helicobacter pylori CagA EPIYA Variants Reveals Differential Activation of Host Cell Signaling Pathways
Q38800246Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways.
Q44036583Helicobacter pylori CagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner.
Q34586831Presence of terminal EPIYA phosphorylation motifs in Helicobacter pylori CagA contributes to IL-8 secretion, irrespective of the number of repeats.

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