| scholarly article | Q13442814 |
| P2093 | author name string | S Shuman | |
| C Cheng | |||
| N Pavletich | |||
| P Kussie | |||
| P2860 | cites work | Improved methods for building protein models in electron density maps and the location of errors in these models | Q26776980 |
| MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures | Q26778412 | ||
| Crystal structure of the amino-terminal fragment of vaccinia virus DNA topoisomerase I at 1.6 A resolution | Q27730798 | ||
| A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications | Q27733270 | ||
| Flexibility in DNA recombination: structure of the lambda integrase catalytic core | Q27735010 | ||
| Molecular organization in site-specific recombination: the catalytic domain of bacteriophage HP1 integrase at 2.7 A resolution | Q27735990 | ||
| Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse | Q27742911 | ||
| Protein structure comparison by alignment of distance matrices | Q27860798 | ||
| DNA topoisomerases | Q29619953 | ||
| Phenotypic selection and characterization of mutant alleles of a eukaryotic DNA topoisomerase I. | Q30403364 | ||
| Resolution of Holliday junctions by eukaryotic DNA topoisomerase I | Q33579262 | ||
| Vaccinia DNA topoisomerase I promotes illegitimate recombination in Escherichia coli | Q33855775 | ||
| Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I. | Q33856425 | ||
| Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I. | Q34325217 | ||
| Eukaryotic topoisomerase I-DNA interaction is stabilized by helix curvature | Q35918001 | ||
| The catalytic domain of lambda site-specific recombinase | Q36179257 | ||
| Step-arrest mutants of FLP recombinase: implications for the catalytic mechanism of DNA recombination | Q36793130 | ||
| Nicking-closing activity associated with bacteriophage lambda int gene product | Q37339246 | ||
| Recombination mediated by vaccinia virus DNA topoisomerase I in Escherichia coli is sequence specific | Q37619381 | ||
| Proteolytic footprinting of vaccinia topoisomerase bound to DNA. | Q38295367 | ||
| Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions | Q38312184 | ||
| Purification and characterization of human topoisomerase I mutants | Q38361294 | ||
| Mechanism of DNA transesterification by vaccinia topoisomerase: catalytic contributions of essential residues Arg-130, Gly-132, Tyr-136 and Lys-167. | Q39720755 | ||
| Mutational analysis of vaccinia virus topoisomerase identifies residues involved in DNA binding | Q39721154 | ||
| Eukaryotic DNA topoisomerases I. | Q40540261 | ||
| Complementation of bacteriophage lambda integrase mutants: evidence for an intersubunit active site. | Q40875014 | ||
| Appendix. II: Alignment of primary sequences of DNA topoisomerases. | Q41315322 | ||
| Topoisomerase I inhibitors: review and update | Q41634169 | ||
| Site-specific recombination in plane view | Q41652330 | ||
| Intramolecular synapsis of duplex DNA by vaccinia topoisomerase | Q41980937 | ||
| Crystal structure of the site-specific recombinase, XerD. | Q42628178 | ||
| Characterization of a DNA topoisomerase encoded by Amsacta moore entomopoxvirus | Q44443149 | ||
| Covalent DNA binding by vaccinia topoisomerase results in unpairing of the thymine base 5' of the scissile bond. | Q52520146 | ||
| Xer recombination in Escherichia coli. Site-specific DNA topoisomerase activity of the XerC and XerD recombinases. | Q54559599 | ||
| Mutational Analysis of 39 Residues of Vaccinia DNA Topoisomerase Identifies Lys-220, Arg-223, and Asn-228 as Important for Covalent Catalysis | Q62606001 | ||
| DNA specificity of the Cre recombinase resides in the 25 kDa carboxyl domain of the protein | Q68642289 | ||
| Mutations within a conserved region of vaccinia topoisomerase affect the DNA cleavage-religation equilibrium | Q71768486 | ||
| Histidine 265 is important for covalent catalysis by vaccinia topoisomerase and is conserved in all eukaryotic type I enzymes | Q73038963 | ||
| Deletions at the carboxyl terminus of vaccinia DNA topoisomerase affect DNA binding and enhance distributivity in DNA relaxation | Q73202276 | ||
| Mutational analysis of 26 residues of vaccinia DNA topoisomerase identifies Ser-204 as important for DNA binding and cleavage | Q73456172 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 841-50 | |
| P577 | publication date | 1998-03-20 | |
| P1433 | published in | Cell | Q655814 |
| P1476 | title | Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases | |
| P478 | volume | 92 |
| Q43851147 | 3D molecular modeling and evolutionary study of the Trypanosoma brucei DNA Topoisomerase IB, as a new emerging pharmacological target |
| Q21192724 | A DNA topoisomerase IB in Thaumarchaeota testifies for the presence of this enzyme in the last common ancestor of Archaea and Eucarya |
| Q27641749 | A conformational switch controls the DNA cleavage activity of lambda integrase |
| Q33421561 | A functional type I topoisomerase from Pseudomonas aeruginosa |
| Q33941096 | A human topoisomerase I cleavage complex is recognized by an additional human topisomerase I molecule in vitro. |
| Q34011317 | A poxvirus-like type IB topoisomerase family in bacteria |
| Q27642687 | A specificity switch in selected cre recombinase variants is mediated by macromolecular plasticity and water |
| Q35925638 | A type IB topoisomerase with DNA repair activities |
| Q41313218 | Active site electrostatics protect genome integrity by blocking abortive hydrolysis during DNA recombination. |
| Q35154537 | All tangled up: how cells direct, manage and exploit topoisomerase function |
| Q38292658 | An insight into the active site of a type I DNA topoisomerase from the kinetoplastid protozoan Leishmania donovani |
| Q35146022 | An unusual type IB topoisomerase from African trypanosomes |
| Q27638420 | Arm-site binding by lambda -integrase: solution structure and functional characterization of its amino-terminal domain |
| Q27618732 | Asymmetric DNA bending in the Cre-loxP site-specific recombination synapse |
| Q24813845 | Atomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion |
| Q44235309 | Attenuating functions of the C terminus of lambda integrase |
| Q44276073 | Benzo[a]pyrene-dG adduct interference illuminates the interface of vaccinia topoisomerase with the DNA minor groove |
| Q44814637 | Benzo[c]phenanthrene adducts and nogalamycin inhibit DNA transesterification by vaccinia topoisomerase |
| Q36082889 | CTnDOT integrase performs ordered homology-dependent and homology-independent strand exchanges |
| Q91903448 | Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins |
| Q42630590 | Catalytic mechanism of DNA topoisomerase IB. |
| Q40177715 | Characterization of DNA Binding by the Isolated N-Terminal Domain of Vaccinia Virus DNA Topoisomerase IB. |
| Q34602383 | Characterization of DNA topoisomerase-1 in Spodoptera exigua for toxicity evaluation of camptothecin and hydoxy-camptothecin |
| Q53623383 | Characterization of a conjugative transposon integrase, IntDOT. |
| Q41754596 | Characterization of a mutation of bacteriophage lambda integrase. Putative role in core binding and strand exchange for a conserved residue. |
| Q40722914 | Characterization of mimivirus DNA topoisomerase IB suggests horizontal gene transfer between eukaryal viruses and bacteria |
| Q30439478 | Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry |
| Q39663967 | Chemical mutagenesis of vaccinia DNA topoisomerase lysine 167 provides insights to the catalysis of DNA transesterification |
| Q35980126 | Coming or going it's another pretty picture for the lambda-Int family album |
| Q41755822 | Conserved themes but novel activities in recombinases and topoisomerases |
| Q77171897 | Cre mutants with altered DNA binding properties |
| Q27662183 | Crystal Structure of a Bacterial Topoisomerase IB in Complex with DNA Reveals a Secondary DNA Binding Site |
| Q27628643 | Crystal structure of a Flp recombinase-Holliday junction complex: assembly of an active oligomer by helix swapping |
| Q42676269 | Crystal structure of a bacterial type IB DNA topoisomerase reveals a preassembled active site in the absence of DNA. |
| Q41616296 | DNA contacts stimulate catalysis by a poxvirus topoisomerase |
| Q38313474 | DNA strand transfer catalyzed by vaccinia topoisomerase: ligation of DNAs containing a 3' mononucleotide overhang |
| Q33734562 | DNA topoisomerase I in oncology: Dr Jekyll or Mr Hyde? |
| Q37255381 | DNA topoisomerases: harnessing and constraining energy to govern chromosome topology |
| Q40323795 | Decatenation of DNA circles by FtsK-dependent Xer site-specific recombination |
| Q38360267 | Differential affinity and cooperativity functions of the amino-terminal 70 residues of lambda integrase |
| Q30723868 | Directed evolution to increase camptothecin sensitivity of human DNA topoisomerase I. |
| Q41912277 | Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure |
| Q35626033 | Diversity and evolution of chromatin proteins encoded by DNA viruses |
| Q44454710 | Dynamics and DNA substrate recognition by the catalytic domain of lambda integrase |
| Q43635286 | Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase |
| Q37383911 | Effects of magnesium and related divalent metal ions in topoisomerase structure and function. |
| Q34003886 | Electrostatic suppression allows tyrosine site-specific recombination in the absence of a conserved catalytic arginine |
| Q35543783 | Enzymes That Cleave and Religate DNA at High Temperature: The Same Story with Different Actors |
| Q39079092 | Evolution of variants of yeast site-specific recombinase Flp that utilize native genomic sequences as recombination target sites |
| Q40454223 | Firefly luciferase enzyme fragment complementation for imaging in cells and living animals. |
| Q77521029 | Flp ribonuclease activities. Mechanistic similarities and contrasts to site-specific DNA recombination |
| Q43786817 | Fluorescence spectroscopy studies of vaccinia type IB DNA topoisomerase. Closing of the enzyme clamp is faster than DNA cleavage |
| Q34032792 | Free energy calculations reveal rotating-ratchet mechanism for DNA supercoil relaxation by topoisomerase IB and its inhibition |
| Q54634087 | Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB. |
| Q33204212 | Functional mapping of Cre recombinase by pentapeptide insertional mutagenesis. |
| Q24548476 | Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics |
| Q38352121 | Guarding the genome: electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB. |
| Q35026064 | Homocamptothecins: potent topoisomerase I inhibitors and promising anticancer drugs |
| Q33633792 | Homology-dependent interactions determine the order of strand exchange by IntDOT recombinase |
| Q34701067 | Human DNA topoisomerase I-mediated cleavage and recombination of duck hepatitis B virus DNA in vitro |
| Q73636302 | Identification of Cre residues involved in synapsis, isomerization, and catalysis |
| Q27938442 | Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation |
| Q31816410 | Inhibition of Flp recombinase by the topoisomerase I-targeting drugs, camptothecin and NSC-314622. |
| Q27659803 | Insights from the Structure of a Smallpox Virus Topoisomerase-DNA Transition State Mimic |
| Q77545285 | Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA |
| Q33712882 | Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. |
| Q29618789 | Mechanism and control of meiotic recombination initiation |
| Q77333600 | Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme |
| Q64233817 | Microheterogeneity of Topoisomerase IA/IB and Their DNA-Bound States |
| Q27641370 | Modulation of the Active Complex Assembly and Turnover Rate by Protein−DNA Interactions in Cre−LoxP Recombination † , ‡ |
| Q42626370 | Mutational analysis of the archaeal tyrosine recombinase SSV1 integrase suggests a mechanism of DNA cleavage in trans |
| Q35024291 | Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA. |
| Q34891480 | Mutations at residues 282, 286, and 293 of phage lambda integrase exert pathway-specific effects on synapsis and catalysis in recombination. |
| Q45265133 | N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit |
| Q54468290 | NBU1 integrase: evidence for an altered recombination mechanism. |
| Q30826416 | New peptide inhibitors of type IB topoisomerases: similarities and differences vis-a-vis inhibitors of tyrosine recombinases |
| Q38309170 | Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase |
| Q37790458 | Nucleases: diversity of structure, function and mechanism. |
| Q34604464 | Phylogenomics of DNA topoisomerases: their origin and putative roles in the emergence of modern organisms |
| Q47858291 | Polynucleotide ligase activity of eukaryotic topoisomerase I. |
| Q37258373 | Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenine |
| Q34027419 | Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes |
| Q37640977 | Poxvirus proteomics and virus-host protein interactions |
| Q41874238 | PprA contributes to Deinococcus radiodurans resistance to nalidixic acid, genome maintenance after DNA damage and interacts with deinococcal topoisomerases |
| Q53641062 | Preferential synapsis of loxP sites drives ordered strand exchange in Cre-loxP site-specific recombination. |
| Q33584109 | Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase |
| Q43833635 | Proton relay mechanism of general acid catalysis by DNA topoisomerase IB. |
| Q37592359 | Pyridoxal 5'-phosphate inactivates DNA topoisomerase IB by modifying the lysine general acid |
| Q64387507 | Recombinogenic flap ligation mediated by human topoisomerase I |
| Q39456436 | Recombinogenic flap ligation pathway for intrinsic repair of topoisomerase IB-induced double-strand breaks |
| Q74334547 | Reconstitution of enzymatic activity by the association of the cap and catalytic domains of human topoisomerase I |
| Q45411325 | Regulation of catalysis by the smallpox virus topoisomerase |
| Q27661545 | Requirements for catalysis in the Cre recombinase active site |
| Q57024691 | Residues within the N-terminal Domain of Human Topoisomerase I Play a Direct Role in Relaxation* |
| Q39542796 | Resolution of a Holliday junction by vaccinia topoisomerase requires a spacer DNA segment 3' of the CCCTT/ cleavage sites |
| Q34246677 | Restoration of catalytic functions in Cre recombinase mutants by electrostatic compensation between active site and DNA substrate. |
| Q34240909 | Reversed DNA strand cleavage specificity in initiation of Cre-LoxP recombination induced by the His289Ala active-site substitution |
| Q33195148 | Reversible inhibitors of lambda integrase-mediated recombination efficiently trap Holliday junction intermediates and form the basis of a novel assay for junction resolution |
| Q47742795 | Role of the N- and C- terminal dimer interfaces of 434 repressor in recognizing sequence-dependent DNA structure |
| Q38358159 | Sequence of the loxP site determines the order of strand exchange by the Cre recombinase |
| Q52611769 | Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA. |
| Q36208186 | Site-Specific Recombination by SSV2 Integrase: Substrate Requirement and Domain Functions |
| Q44543805 | Site-specific DNA transesterification by vaccinia topoisomerase: effects of benzo[alpha]pyrene-dA, 8-oxoguanine, 8-oxoadenine and 2-aminopurine modifications |
| Q36258273 | Strand selection by the tyrosine recombinases |
| Q45144053 | Structural and functional characterization of the C-terminal catalytic domain of SSV1 integrase |
| Q74520769 | Structural insights into the function of type IB topoisomerases |
| Q27640404 | Structural plasticity of the Flp-Holliday junction complex |
| Q37108394 | Structural studies of type I topoisomerases |
| Q33536604 | Structure and mechanism in site-specific recombination |
| Q46651773 | Structure of DNA topoisomerases |
| Q27676525 | Structure of Yeast Kinetochore Ndc10 DNA-binding Domain Reveals Unexpected Evolutionary Relationship to Tyrosine Recombinases |
| Q34067004 | Structure of the Holliday junction intermediate in Cre-loxP site-specific recombination. |
| Q24541378 | Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases |
| Q54051610 | Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate. |
| Q37358946 | Suppression of lupus nephritis and skin lesions in MRL/lpr mice by administration of the topoisomerase I inhibitor irinotecan |
| Q37068250 | Teaching Cre to follow directions |
| Q47948885 | Teaching a new dog old tricks? |
| Q27678107 | The Carboxy-Terminal αN Helix of the Archaeal XerA Tyrosine Recombinase Is a Molecular Switch to Control Site-Specific Recombination |
| Q27639100 | The Order of Strand Exchanges in Cre-LoxP Recombination and its Basis Suggested by the Crystal Structure of a Cre-LoxP Holliday Junction Complex |
| Q24299056 | The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I |
| Q41910093 | The age of reverse biochemistry |
| Q44780529 | The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons. |
| Q43815826 | The domain organization and properties of individual domains of DNA topoisomerase V, a type 1B topoisomerase with DNA repair activities. |
| Q24679341 | The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53 |
| Q38170306 | The molecular biology of nairoviruses, an emerging group of tick-borne arboviruses |
| Q27641062 | The role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysis |
| Q38303603 | The small DNA binding domain of lambda integrase is a context-sensitive modulator of recombinase functions |
| Q27620459 | The structure of Escherichia coli DNA topoisomerase III |
| Q34061976 | Topoisomerase I-mediated DNA damage |
| Q28246272 | Topoisomerase V relaxes supercoiled DNA by a constrained swiveling mechanism |
| Q37810595 | Topoisomerases and site-specific recombinases: similarities in structure and mechanism |
| Q49832269 | Topoisomerases as anticancer targets |
| Q32030823 | Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins |
| Q36082529 | Trans cooperativity by a split DNA recombinase: the central and catalytic domains of bacteriophage lambda integrase cooperate in cleaving DNA substrates when the two domains are not covalently linked. |
| Q38291539 | Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery |
| Q39542667 | Two tricks in one bundle: helix-turn-helix gains enzymatic activity |
| Q27684009 | Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases |
| Q33786691 | Vaccinia topoisomerase and Cre recombinase catalyze direct ligation of activated DNA substrates containing a 3'-para-nitrophenyl phosphate ester |
| Q43664660 | Vaccinia topoisomerase mutants illuminate conformational changes during closure of the protein clamp and assembly of a functional active site |
| Q79293420 | Vaccinia topoisomerase mutants illuminate roles for Phe59, Gly73, Gln69 and Phe215 |
| Q45753690 | Vaccinia virus DNA topoisomerase: a model eukaryotic type IB enzyme |
| Q38351515 | Vanadate-based transition-state analog inhibitors of Cre-LoxP recombination |
| Q43101087 | Variola virus topoisomerase: DNA cleavage specificity and distribution of sites in Poxvirus genomes |
| Q33890413 | Wild-type Flp recombinase cleaves DNA in trans. |
| Q39951018 | topIb, a phylogenetic hallmark gene of Thaumarchaeota encodes a functional eukaryote-like topoisomerase IB. |
| Q58215039 | α Complementation in the Cre recombinase enzyme |
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