Macromolecular TLS refinement in REFMAC at moderate resolutions

scientific article (publication date: 2003)

Macromolecular TLS refinement in REFMAC at moderate resolutions is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0076-6879(03)74014-2
P3181OpenCitations bibliographic resource ID450021
P698PubMed publication ID14696379

P2093author name stringGarib N Murshudov
Miroslav Z Papiz
Martyn D Winn
P2860cites workThree-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzymeQ24555780
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricusQ27619382
The 1.0 A crystal structure of Ca(2+)-bound calmodulin: an analysis of disorder and implications for functionally relevant plasticityQ27626826
The three-dimensional structure of human S100A12Q27629073
Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilisQ27630479
The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivityQ27631051
The crystallographic structure of the mannitol 2-dehydrogenase NADP+ binary complex from Agaricus bisporusQ27631583
Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteinsQ27634433
Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G proteinQ27638981
X-ray crystal structure of benzoate 1,2-dioxygenase reductase from Acinetobacter sp. strain ADP1Q27639085
The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisitionQ27640027
The structure and thermal motion of the B800-850 LH2 complex from Rps.acidophila at 2.0A resolution and 100K: new structural features and functionally relevant motionsQ27640534
Segmented anisotropic refinement of bovine ribonuclease A by the application of the rigid-body TLS modelQ27701592
Use of TLS parameters to model anisotropic displacements in macromolecular refinementQ27860499
Raster3D: photorealistic molecular graphicsQ27860557
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
Efficient anisotropic refinement of macromolecular structures using FFTQ27861028
The CCP4 suite: programs for protein crystallographyQ27861090
Full-matrix refinement of the protein crambin at 0.83 A and 130 K.Q30342576
Normal mode refinement: crystallographic refinement of protein dynamic structure. I. Theory and test by simulated diffraction dataQ30991399
Refinement of protein dynamic structure: normal mode refinementQ33580838
Objective comparison of protein structures: error-scaled difference distance matricesQ33922462
Anisotropy of fluctuation dynamics of proteins with an elastic network modelQ33931550
Local mobility of nucleic acids as determined from crystallographic data. I. RNA and B form DNA.Q36592174
Rigid protein motion as a model for crystallographic temperature factorsQ37462108
Domain flexibility in aspartic proteinasesQ43726275
The segmented anisotropic refinement of monoclinic papain by the application of the rigid-body TLS model and comparison to bovine ribonuclease A.Q44275054
On the use of normal modes in thermal parameter refinement: theory and application to the bovine pancreatic trypsin inhibitorQ52483636
Gaussian Dynamics of Folded ProteinsQ56688813
Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic AnalysisQ56688821
TLSANL: TLS parameter-analysis program for segmented anisotropic refinement of macromolecular structuresQ57018564
RESTRAIN: restrained structure-factor least-squares refinement program for macromolecular structuresQ57018591
Crystal structure of an integral membrane light-harvesting complex from photosynthetic bacteriaQ58004320
Atomic Dispacement Parameter Nomenclature. Report of a Subcommittee on Atomic Displacement Parameter NomenclatureQ63987791
P407language of work or nameEnglishQ1860
P921main subjectmacromoleculeQ178593
P304page(s)300-21
P577publication date2003-01-01
P1433published inMethods in EnzymologyQ2076903
P1476titleMacromolecular TLS refinement in REFMAC at moderate resolutions
P478volume374

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cites work (P2860)
Q57266570A CLC-type F/H antiporter in ion-swapped conformations
Q27652253A Double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms
Q27674601A Green Fluorescent Protein Containing a QFG Tri-Peptide Chromophore: Optical Properties and X-Ray Crystal Structure
Q27672783A New Structural Form in the SAM/Metal-Dependent O‑Methyltransferase Family: MycE from the Mycinamicin Biosynthetic Pathway
Q27678262A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase
Q27677840A Variable Light Domain Fluorogen Activating Protein Homodimerizes To Activate Dimethylindole Red
Q30414103A broad specificity nucleoside kinase from Thermoplasma acidophilum
Q27682741A conserved MCM single-stranded DNA binding element is essential for replication initiation
Q27644333A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 Å resolution
Q35907697A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone
Q27694705A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site
Q27666675A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification
Q30435246A linear relationship between crystal size and fragment binding time observed crystallographically: implications for fragment library screening using acoustic droplet ejection
Q27683804A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima
Q36337638A novel transcriptional regulator of L-arabinose utilization in human gut bacteria
Q30422755A pathogen type III effector with a novel E3 ubiquitin ligase architecture
Q30422180A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids
Q36228473A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
Q27658363ATP-dependent MurE ligase in Mycobacterium tuberculosis: biochemical and structural characterisation
Q27658313Acidianus filamentous virus 1 coat proteins display a helical fold spanning the filamentous archaeal viruses lineage
Q30420051Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening
Q27671326Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721
Q27655559Allosteric Site Variants of Haemophilus influenzae β-Carbonic Anhydrase
Q27656445Amidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating Enzyme
Q36075317An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Q36141181An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions
Q41452503An induced fit conformational change underlies the binding mechanism of the heme transport proteobacteria-protein HemS.
Q90157473An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP
Q27701492Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions
Q27682327Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO)
Q42060135Analysis of structural dynamics in the ribosome by TLS crystallographic refinement
Q27676072Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily
Q37008862Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
Q38638522Assessment of the Target Engagement and D-Serine Biomarker Profiles of the D-Amino Acid Oxidase Inhibitors Sodium Benzoate and PGM030756.
Q27652648Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine
Q34451878Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex
Q34283536Automated electron-density sampling reveals widespread conformational polymorphism in proteins
Q33454096Automatic rebuilding and optimization of crystallographic structures in the Protein Data Bank
Q27681206Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis
Q27666695Autotransporter passenger domain secretion requires a hydrophobic cavity at the extracellular entrance of the β-domain pore
Q27671647Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases
Q27678314Binding Modes of Zaragozic Acid A to Human Squalene Synthase and Staphylococcal Dehydrosqualene Synthase
Q27675880Biochemical and Structural Studies of Uncharacterized Protein PA0743 from Pseudomonas aeruginosa Revealed NAD+-dependent L-Serine Dehydrogenase
Q36350988Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis
Q27701595Biogenesis and structure of a type VI secretion membrane core complex
Q27667818Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis
Q52658388CCP4i2: the new graphical user interface to the CCP4 program suite.
Q36214456Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
Q27670930Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System
Q24650824Catalytic cycle of human glutathione reductase near 1 A resolution
Q35728121Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate
Q27681172Chiral-substrate-assisted stereoselective epoxidation catalyzed by H2O2-dependent cytochrome P450SPα
Q54961325Chloroplastic Serine Hydroxymethyltransferase From Medicago truncatula: A Structural Characterization.
Q91826058Cinnamaldehyde and Phenyl Ethyl Alcohol promote the entrapment of intermediate species of HEWL, as revealed by structural, kinetics and thermal stability studies
Q27679409Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
Q27677060Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
Q27664639Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain
Q27678610Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ Subsites
Q27658331Conformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus Assembly
Q27644463Conformational changes associated with the binding of zinc acetate at the putative active site of Xc TcmJ, a cupin from Xanthomonas campestris pv. campestris
Q45129829Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation
Q36414802Conformational variation of an extreme drug resistant mutant of HIV protease
Q36088381Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies.
Q47261759Contribution of Buried Distal Amino Acid Residues in Horse Liver Alcohol Dehydrogenase to Structure and Catalysis
Q35054422Control of repeat-protein curvature by computational protein design
Q38718346Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization
Q64085386Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a
Q27648884Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida
Q30250932Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope
Q64955791Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire.
Q27657544Crystal Structure and Functional Analysis of Homocitrate Synthase, an Essential Enzyme in Lysine Biosynthesis
Q27650265Crystal Structure and Raman Studies of dsFP483, a Cyan Fluorescent Protein from Discosoma striata
Q27488305Crystal Structure of Dengue Virus Type 1 Envelope Protein in the Postfusion Conformation and Its Implications for Membrane Fusion
Q27670625Crystal Structure of H2O2-dependent Cytochrome P450SP  with Its Bound Fatty Acid Substrate: INSIGHT INTO THE REGIOSELECTIVE HYDROXYLATION OF FATTY ACIDS AT THE   POSITION
Q27655504Crystal Structure of Histidine Phosphotransfer Protein ShpA, an Essential Regulator of Stalk Biogenesis in Caulobacter crescentus
Q37578931Crystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode
Q27677465Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30
Q27666500Crystal Structure of UBA2ufd-Ubc9: Insights into E1-E2 Interactions in Sumo Pathways
Q27477610Crystal Structure of West Nile Virus Envelope Glycoprotein Reveals Viral Surface Epitopes
Q27676797Crystal Structure of an Insect Antifreeze Protein and Its Implications for Ice Binding
Q27681361Crystal Structure of the Catalytic Domain of the Bacillus cereus SleB Protein, Important in Cortex Peptidoglycan Degradation during Spore Germination
Q27670602Crystal Structure of the E2 Domain of Amyloid Precursor Protein-like Protein 1 in Complex with Sucrose Octasulfate
Q27644430Crystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA Repair
Q27675720Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3
Q27674666Crystal Structure of the Passenger Domain of the Escherichia coli Autotransporter EspP
Q27659797Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway
Q36644761Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030
Q27673332Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity
Q27653952Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains
Q27650110Crystal Structures of the Response Regulator DosR from Mycobacterium tuberculosis Suggest a Helix Rearrangement Mechanism for Phosphorylation Activation
Q56396453Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon
Q27675292Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region
Q27676745Crystal structure of JlpA, a surface-exposed lipoprotein adhesin of Campylobacter jejuni
Q27643934Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis
Q39965692Crystal structure of Thermoplasma acidophilum XerA recombinase shows large C-shape clamp conformation and cis-cleavage mode for nucleophilic tyrosine
Q37059948Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization
Q27679089Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site
Q27667656Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity
Q27653173Crystal structure of a novel archaeal AAA+ ATPase SSO1545 fromSulfolobus solfataricus
Q27680491Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family
Q50863793Crystal structure of a tankyrase 1-telomere repeat factor 1 complex.
Q27663517Crystal structure of a truncated urease accessory protein UreF from Helicobacter pylori
Q27679542Crystal structure of a voltage-gated sodium channel in two potentially inactivated states
Q27678201Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation
Q27674231Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization
Q34194742Crystal structure of clustered regularly interspaced short palindromic repeats (CRISPR)-associated Csn2 protein revealed Ca2+-dependent double-stranded DNA binding activity.
Q27675741Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe
Q27680279Crystal structure of human CK2α at 1.06 Å resolution
Q27667308Crystal structure of inhibitor of κB kinase β
Q27643217Crystal structure of the HRDC domain of human Werner syndrome protein, WRN
Q27646838Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans
Q47380035Crystal structure of the Legionella effector Lem22.
Q27674051Crystal structure of the N-terminal domain of linker L(R) and the assembly of cyanobacterial phycobilisome rods
Q33855642Crystal structure of the Staphylococcus aureus pI258 CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor
Q27653393Crystal structure of the dimerization domain of human filamin A
Q27681762Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater
Q27678888Crystal structure of the ubiquitin-like small archaeal modifier protein 2 fromHaloferax volcanii
Q27679236Crystal structure ofSaccharomyces cerevisiaeAro8, a putative α-aminoadipate aminotransferase
Q30432139Crystal structures and RNA-binding properties of the RNA recognition motifs of heterogeneous nuclear ribonucleoprotein L: insights into its roles in alternative splicing regulation
Q35126546Crystal structures capture three states in the catalytic cycle of a pyridoxal phosphate (PLP) synthase
Q50223712Crystal structures of Dronpa complexed with quenchable metal ions provide insight into metal biosensor development.
Q38735298Crystal structures of human 3-hydroxyanthranilate 3,4-dioxygenase with native and non-native metals bound in the active site
Q36620746Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements
Q27674857Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
Q30153361Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake
Q27644377Crystallographic structure of the SH3 domain of the human c-Yes tyrosine kinase: loop flexibility and amyloid aggregation
Q46050747D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies
Q27654769DNA Synthesis across an Abasic Lesion by Human DNA Polymerase ι
Q33635112DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target
Q27678511Degradation of Phytate by the 6-Phytase from Hafnia alvei: A Combined Structural and Solution Study
Q33365163Differential CLE peptide perception by plant receptors implicated from structural and functional analyses of TDIF-TDR interactions.
Q27665185Differential Reactivity between Two Copper Sites in Peptidylglycine α-Hydroxylating Monooxygenase
Q35076369Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine
Q27660451Dimeric Architecture of the Hendra Virus Attachment Glycoprotein: Evidence for a Conserved Mode of Assembly
Q27676487Dimerization of Bacterial Diaminopimelate Epimerase Is Essential for Catalysis
Q28546429Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease
Q36332051Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
Q27660550Domain Metastability: A Molecular Basis for Immunoglobulin Deposition?
Q34297176Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein
Q27679710E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1
Q90638254ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation
Q27681376Effects of Cavities at the Nicotinamide Binding Site of Liver Alcohol Dehydrogenase on Structure, Dynamics and Catalysis
Q30400367Effects of T-loop modification on the PII-signalling protein: structure of uridylylated Escherichia coli GlnB bound to ATP.
Q90859888Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut
Q27650863Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir
Q47549555Epsin and Sla2 form assemblies through phospholipid interfaces
Q27644397Escherichia coli MutS tetramerization domain structure reveals that stable dimers but not tetramers are essential for DNA mismatch repair in vivo
Q27682749Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer
Q27663457Evolution of New Enzymatic Function by Structural Modulation of Cysteine Reactivity in Pseudomonas fluorescens Isocyanide Hydratase
Q27684351Exploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT.
Q27678169Extra-domain B in Oncofetal Fibronectin Structurally Promotes Fibrillar Head-to-tail Dimerization of Extracellular Matrix Protein
Q48094154FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system
Q27657969Fine tuning of the E. coli NusB:NusE complex affinity to BoxA RNA is required for processive antitermination
Q27664205Folding, DNA Recognition, and Function of GIY-YIG Endonucleases: Crystal Structures of R.Eco29kI
Q27670432Friedreich’s Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron–Sulfur Cluster Assembly Complex
Q35927497From deep TLS validation to ensembles of atomic models built from elemental motions
Q27676125Full-length Gαq–phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain
Q27678009Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima
Q27679203Functional significance of four successive glycine residues in the pyrophosphate binding loop of fungal 6-oxopurine phosphoribosyltransferases
Q39062848Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422.
Q27658966Genomics, evolution, and crystal structure of a new family of bacterial spore kinases
Q27682664Groove-type Recognition of Chlamydiaceae-specific Lipopolysaccharide Antigen by a Family of Antibodies Possessing an Unusual Variable Heavy Chain N-Linked Glycan
Q27664196H-NS forms a superhelical protein scaffold for DNA condensation
Q46445841High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.
Q27664009High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides
Q27667713High-resolution structure of exo-arabinanase from Penicillium chrysogenum
Q27681684High-resolution structures of Neotermes koshunensis β-glucosidase mutants provide insights into the catalytic mechanism and the synthesis of glucoconjugates
Q27664650Holo-Ni(II) Hp NikR Is an Asymmetric Tetramer Containing Two Different Nickel-Binding Sites
Q45345092Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota
Q27658743How Much Binding Affinity Can be Gained by Filling a Cavity?
Q27676064Human DNA Polymerase η Is Pre-Aligned for dNTP Binding and Catalysis
Q27684442IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family
Q89427945Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors
Q27674976Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies
Q27683701Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ)
Q27656851Impaired Protofibril Formation in Fibrinogen γN308K Is Due to Altered D:D and “A:a” Interactions ,
Q40132138Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP/VAMP7 by tyrosine phosphorylation in the Longin domain
Q28481493Inflammation-associated nitrotyrosination affects TCR recognition through reduced stability and alteration of the molecular surface of the MHC complex
Q63379297Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis
Q24338779Inhibition of basal FGF receptor signaling by dimeric Grb2
Q27677544Insights into BAY 60-2770 Activation and S -Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes
Q24336251Insights into mucopolysaccharidosis I from the structure and action of α-L-iduronidase
Q36232908Insights into role of the hydrogen bond networks in substrate recognition by UDP-GalNAc 4-epimerases.
Q27680459Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs
Q36996208Interaction of haptoglobin with hemoglobin octamers based on the mutation αAsn78Cys or βGly83Cys
Q27648798Interactions and dynamics of the Shine Dalgarno helix in the 70S ribosome
Q46076655Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily
Q27659910Kinetics of Mismatch Formation opposite Lesions by the Replicative DNA Polymerase from Bacteriophage RB69
Q64103394L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
Q27666034La-Related Protein 4 Binds Poly(A), Interacts with the Poly(A)-Binding Protein MLLE Domain via a Variant PAM2w Motif, and Can Promote mRNA Stability
Q27677496Large Lateral Movement of Transmembrane Helix S5 Is Not Required for Substrate Access to the Active Site of Rhomboid Intramembrane Protease
Q27652758Lesion Bypass of N2-Ethylguanine by Human DNA Polymerase ι
Q27667091Ligand-Dependent Disorder of the   Loop Observed in Extended-Spectrum SHV-Type  -Lactamase
Q33771033MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway
Q27667563Mechanism of RecO recruitment to DNA by single-stranded DNA binding protein
Q41962253Mechanistic signs of double-barreled structure in a fluoride ion channel
Q47259369Methylation-regulated decommissioning of multimeric PP2A complexes.
Q24671640MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone
Q39677195Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity
Q48115661Molecular Interactions between a Fluoride Ion Channel and Synthetic Protein Blockers.
Q24307891Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein
Q27684034Molecular characterization of novel pyridoxal-5′-phosphate-dependent enzymes from the human microbiome
Q42241021Molecular determinants of permeation in a fluoride-specific ion channel.
Q35019768Molecular mechanisms of phospholipase C β3 autoinhibition.
Q35567105Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus
Q27677471New Insight into the Transcarbamylase Family: The Structure of Putrescine Transcarbamylase, a Key Catalyst for Fermentative Utilization of Agmatine
Q35997972New aminopeptidase from "microbial dark matter" archaeon
Q27650299Ninety-Nine Is Not Enough: Molecular Characterization of Inhibitor-Resistant Human Immunodeficiency Virus Type 1 Protease Mutants with Insertions in the Flap Region
Q34683392Novel mechanism of hemin capture by Hbp2, the hemoglobin-binding hemophore from Listeria monocytogenes
Q27674624Nucleic acid binding surface and dimer interface revealed by CRISPR-associated CasB protein structures
Q34580389Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies
Q27644222Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding
Q27653247Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation
Q27860782Overview of the CCP4 suite and current developments
Q27667828Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase
Q27678795Plasmodium falciparum SSB Tetramer Wraps Single-Stranded DNA with Similar Topology but Opposite Polarity to E. coli SSB
Q36466161Plasticity in Repressor-DNA Interactions Neutralizes Loss of Symmetry in Bipartite Operators.
Q27663668PoxA, YjeK, and Elongation Factor P Coordinately Modulate Virulence and Drug Resistance in Salmonella enterica
Q27680728RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state
Q42585595Reassembly and co-crystallization of a family 9 processive endoglucanase from its component parts: structural and functional significance of the intermodular linker
Q27673699RecOR complex including RecR N-N dimer and RecO monomer displays a high affinity for ssDNA
Q27697333Recognition determinants of broadly neutralizing human antibodies against dengue viruses
Q24303887Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
Q27681506Reducing virulence of the human pathogen Burkholderia by altering the substrate specificity of the quorum-quenching acylase PvdQ
Q38371689Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation
Q36252642Revisiting the role of glycosylation in the structure of human IgG Fc.
Q27667071Role of Human DNA Polymerase κ in Extension Opposite from a cis–syn Thymine Dimer
Q27675812Roles of the A and C Sites in the Manganese-Specific Activation of MntR
Q27678384Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions
Q27667247Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)
Q27682733Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)
Q27674788Spacing between core recognition motifs determines relative orientation of AraR monomers on bipartite operators
Q58109473Spectral and structural analysis of a red fluorescent protein from Acropora digitifera
Q64248973Spermidine Synthase (SPDS) Undergoes Concerted Structural Rearrangements Upon Ligand Binding - A Case Study of the Two SPDS Isoforms From
Q91595587SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities
Q41686709Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control
Q90401651Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana- the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis
Q27658650Structural Analysis of Rtt106p Reveals a DNA Binding Role Required for Heterochromatin Silencing
Q27678419Structural Analysis of a Dengue Cross-Reactive Antibody Complexed with Envelope Domain III Reveals the Molecular Basis of Cross-Reactivity
Q27667496Structural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant Glutamine
Q36186122Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor
Q27647673Structural Basis for Activation of Fatty Acid-binding Protein 4
Q27677059Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker
Q27671678Structural Basis for Acyl Acceptor Specificity in the Achromobactin Biosynthetic Enzyme AcsD
Q35925821Structural Basis for Antibody Recognition of Lipid A: INSIGHTS TO POLYSPECIFICITY TOWARD SINGLE-STRANDED DNA.
Q57170505Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment
Q27665830Structural Basis for Error-free Replication of Oxidatively Damaged DNA by Yeast DNA Polymerase η
Q27659064Structural Basis for L-Lysine Feedback Inhibition of Homocitrate Synthase
Q27665230Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase ι
Q27679160Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins
Q27650407Structural Basis for the Inactivation of Thermus thermophilus Proline Dehydrogenase by N- Propargylglycine † , ‡
Q27664787Structural Basis of Carbohydrate Recognition by Calreticulin
Q27664213Structural Basis of Cyclophilin B Binding by the Calnexin/Calreticulin P-domain
Q27667500Structural Basis of Defects in the Sacsin HEPN Domain Responsible for Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)
Q27649002Structural Basis of J Cochaperone Binding and Regulation of Hsp70
Q27649536Structural Basis of Vta1 Function in the Multivesicular Body Sorting Pathway
Q27675322Structural Basis of the Interaction of MbtH-like Proteins, Putative Regulators of Nonribosomal Peptide Biosynthesis, with Adenylating Enzymes
Q27648853Structural Characterization of the ATPase Reaction Cycle of Endosomal AAA Protein Vps4
Q27673780Structural Differences between the Streptococcus agalactiae Housekeeping and Pilus-Specific Sortases: SrtA and SrtC1
Q27659994Structural Elucidation of Cisoid and Transoid Cyclization Pathways of a Sesquiterpene Synthase Using 2-Fluorofarnesyl Diphosphates
Q27663896Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases
Q27670462Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21
Q27655690Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschii
Q36740559Structural Investigations of N-carbamoylputrescine Amidohydrolase from Medicago truncatula: Insights into the Ultimate Step of Putrescine Biosynthesis in Plants
Q88918480Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor
Q27673588Structural States and Dynamics of the D-Loop in Actin
Q97521800Structural Studies of Glutamate Dehydrogenase (Isoform 1) From Arabidopsis thaliana, an Important Enzyme at the Branch-Point Between Carbon and Nitrogen Metabolism
Q27665857Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2
Q64107069Structural Study of Agmatine Iminohydrolase From , the Second Enzyme of the Agmatine Route of Putrescine Biosynthesis in Plants
Q51596676Structural analysis of a function-associated loop mutant of the substrate-recognition domain of Fbs1 ubiquitin ligase.
Q34299260Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications
Q24684707Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily
Q27674692Structural and Biochemical Characterization of the Salicylyl-acyltranferase SsfX3 from a Tetracycline Biosynthetic Pathway
Q90189766Structural and Dynamical Basis of G Protein Inhibition by YM-254890 and FR900359: An Inhibitor in Action
Q27681736Structural and Functional Analysis of the GerD Spore Germination Protein of Bacillus Species
Q27655362Structural and Functional Analysis of the Globular Head Domain of p115 Provides Insight into Membrane Tethering
Q27655359Structural and Functional Characterisation of a Conserved Archaeal RadA Paralog with Antirecombinase Activity
Q27666269Structural and Functional Relationships between the Lectin and Arm Domains of Calreticulin
Q27662573Structural and Functional Study of Yer067w, a New Protein Involved in Yeast Metabolism Control and Drug Resistance
Q96953993Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family
Q27681760Structural and enzymatic characterization of a host-specificity determinant fromSalmonella
Q27663865Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensis
Q41077398Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Q64244558Structural and functional characterization of a frataxin from a thermophilic organism
Q27644082Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes
Q52316858Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in Streptococcus pneumoniae.
Q116166980Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2
Q27646764Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase
Q27675827Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
Q27678933Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy
Q27679972Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer
Q27694370Structural basis for outer membrane lipopolysaccharide insertion
Q24615547Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain
Q27695602Structural basis for the assembly of the Sxl-Unr translation regulatory complex
Q27649811Structural basis for the binding of naproxen to human serum albumin in the presence of fatty acids and the GA module
Q24293301Structural basis for the recognition and cleavage of histone H3 by cathepsin L
Q34161123Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.
Q27664442Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
Q58586503Structural basis for the recognition of sulfur in phosphorothioated DNA
Q27683532Structural basis for the site-specific incorporation of lysine derivatives into proteins
Q27662723Structural basis for the suppression of skin cancers by DNA polymerase η
Q39290864Structural basis for the transcriptional repressor NicR2 in nicotine degradation from Pseudomonas
Q27680173Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone
Q24300961Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein
Q27646886Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides
Q24601494Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta
Q43101448Structural basis of lipid biosynthesis regulation in Gram-positive bacteria
Q45936156Structural basis of nonribosomal peptide macrocyclization in fungi.
Q27677410Structural basis of protein phosphatase 2A stable latency
Q27664443Structural basis of substrate recognition and specificity in the N-end rule pathway
Q37522326Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis
Q41837246Structural determinants of reductive terpene cyclization in iridoid biosynthesis.
Q27704759Structural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic properties
Q47838381Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities
Q33655445Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase
Q24336678Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations
Q47154975Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane
Q24339542Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci
Q30155839Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms
Q27685491Structural insights into incorporation of norbornene amino acids for click modification of proteins
Q52338894Structural insights into the RNA methyltransferase domain of METTL16.
Q35865669Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex
Q27654234Structural insights into the cooperative binding of SeqA to a tandem GATC repeat
Q35671448Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)
Q36314674Structural insights into the regulation of Bacillus subtilis SigW activity by anti-sigma RsiW
Q51760538Structural insights into the specific recognition of N-heterocycle biodenitrogenation-derived substrates by microbial amide hydrolases.
Q42416822Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity
Q37533158Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway
Q27657299Structural mechanisms for the 5'-CCWGG sequence recognition by the N- and C-terminal domains of EcoRII
Q44134920Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species
Q61800203Structural studies of a surface-entropy reduction mutant of O-GlcNAcase
Q47450231Structural studies of domain movement in active-site mutants of porphobilinogen deaminase from Bacillus megaterium.
Q37146607Structural studies on flavodiiron proteins
Q27675902Structure Analysis of a New Psychrophilic Marine Protease
Q27660959Structure and Activity of the Metal-independent Fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae
Q40736243Structure and Evolution of the Archaeal Lipid Synthesis Enzyme sn-Glycerol-1-phosphate Dehydrogenase
Q27653060Structure and Function of Colicin S4, a Colicin with a Duplicated Receptor-binding Domain
Q27680320Structure and Function of a Novel LD-Carboxypeptidase A Involved in Peptidoglycan Recycling
Q27677285Structure and Function of the DUF2233 Domain in Bacteria and in the Human Mannose 6-Phosphate Uncovering Enzyme
Q27667344Structure and Function of the First Full-Length Murein Peptide Ligase (Mpl) Cell Wall Recycling Protein
Q27644004Structure and Kinetics of Monofunctional Proline Dehydrogenase from Thermus thermophilus
Q27660353Structure and Protein-Protein Interaction Studies on Chlamydia trachomatis Protein CT670 (YscO Homolog)
Q27661034Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX
Q35626315Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference
Q27334123Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme
Q27678633Structure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica
Q35124725Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis
Q27677070Structure and mechanism of the UvrA-UvrB DNA damage sensor
Q27689753Structure and possible mechanism of the CcbJ methyltransferase from Streptomyces caelestis
Q35294122Structure and sequence analyses of Bacteroides proteins BVU_4064 and BF1687 reveal presence of two novel predominantly-beta domains, predicted to be involved in lipid and cell surface interactions
Q35201812Structure determination of feline calicivirus virus-like particles in the context of a pseudo-octahedral arrangement
Q27703521Structure of AmtR, the global nitrogen regulator of Corynebacterium glutamicum, in free and DNA-bound forms
Q27644435Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules
Q27644340Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 Å resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism
Q36055544Structure of BipA in GTP form bound to the ratcheted ribosome
Q27672351Structure of Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein: Superhelical Homo-Oligomers and the Role of Caspase-3 Cleavage
Q90197054Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
Q27649761Structure of Escherichia coli tetrahydrodipicolinate N-succinyltransferase reveals the role of a conserved C-terminal helix in cooperative substrate binding
Q27652487Structure of L-Xylulose-5-Phosphate 3-Epimerase (UlaE) from the Anaerobic L-Ascorbate Utilization Pathway of Escherichia coli: Identification of a Novel Phosphate Binding Motif within a TIM Barrel Fold
Q27673239Structure of a Novel Winged-Helix Like Domain from Human NFRKB Protein
Q27666363Structure of a Slow CLC Cl − /H + Antiporter from a Cyanobacterium
Q27677046Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing
Q27644442Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron
Q27655107Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2′-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine
Q27644214Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15
Q27644451Structure of a tryptophanyl-tRNA synthetase containing an iron–sulfur cluster
Q27681235Structure of an As(III) S -Adenosylmethionine Methyltransferase: Insights into the Mechanism of Arsenic Biotransformation
Q27676339Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler
Q27676170Structure of an amidohydrolase, SACOL0085, from methicillin-resistantStaphylococcus aureusCOL
Q27644209Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 Å resolution
Q27661554Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase
Q27644622Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import
Q24646723Structure of complement fragment C3b-factor H and implications for host protection by complement regulators
Q27670753Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor
Q39840325Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions
Q27677202Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions
Q98471339Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements
Q27678559Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation
Q27652466Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli
Q27655583Structure of the Human Rev1–DNA–dNTP Ternary Complex
Q27649526Structure of the N-Terminal Mlp1-Binding Domain of the Saccharomyces cerevisiae mRNA-Binding Protein, Nab2
Q27649564Structure of the N-Terminal Oligomerization Domain of DnaD Reveals a Unique Tetramerization Motif and Provides Insights into Scaffold Formation
Q27659275Structure of the Ni(II) complex of Escherichia coli peptide deformylase and suggestions on deformylase activities depending on different metal(II) centres
Q27652850Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases
Q40075039Structure of the TBC1D7-TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region
Q36459391Structure of the Y94F mutant of Escherichia coli thymidylate synthase
Q27644170Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation
Q27644134Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism
Q21131595Structure of the head of the Bartonella adhesin BadA
Q27650656Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle
Q27675407Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori
Q27682438Structure of the substrate-binding b′ domain of the Protein disulfide isomerase-like protein of the testis
Q27678528Structure of the third catalytic domain of the protein disulfide isomerase ERp46
Q27653191Structure of the transcriptional regulator LmrR and its mechanism of multidrug recognition
Q27663914Structure of uracil-DNA glycosylase fromMycobacterium tuberculosis: insights into interactions with ligands
Q58611623Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI
Q27674945Structure-Based Engineering Increased the Catalytic Turnover Rate of a Novel Phenazine Prenyltransferase
Q27671293Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range
Q52591099Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
Q27644865Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding
Q34433997Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation
Q27667527Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
Q42376257Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition.
Q41619763Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD+ Binding and the Cofactor Positioned to Accept a Hydride
Q36882749Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners.
Q27675530Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives
Q93023611Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation
Q27644109Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism
Q27644200Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction
Q27644457Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger
Q57039976Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations
Q27670917Structure–Function Analysis of Friedreich’s Ataxia Mutants Reveals Determinants of Frataxin Binding and Activation of the Fe–S Assembly Complex
Q47796953Studies on cyanobacterial protein PipY shed light on structure, potential functions, and vitamin B6 -dependent epilepsy
Q41768038Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates
Q91943742Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin
Q37695985TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis.
Q34219084TLS from fundamentals to practice
Q27661646TM0486 from the Hyperthermophilic Anaerobe Thermotoga maritima is a Thiamin-binding Protein Involved in Response of the Cell to Oxidative Conditions
Q34016388The 1.4 A crystal structure of the ArsD arsenic metallochaperone provides insights into its interaction with the ArsA ATPase
Q27677162The 1.58 Å resolution structure of the DNA-binding domain of bacteriophage SF6 small terminase provides new hints on DNA binding
Q27675697The 1.75 Å resolution structure of fission protein Fis1 fromSaccharomyces cerevisiaereveals elusive interactions of the autoinhibitory domain
Q30385146The Combining Sites of Anti-lipid A Antibodies Reveal a Widely Utilized Motif Specific for Negatively Charged Groups
Q27654068The Crystal Structure of Aquifex aeolicus Prephenate Dehydrogenase Reveals the Mode of Tyrosine Inhibition
Q27676609The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target
Q27671738The Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification Pathway
Q27491317The Development of Therapeutic Antibodies That Neutralize Homologous and Heterologous Genotypes of Dengue Virus Type 1
Q27667862The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization
Q49598512The Extracellular Domain of Pollen Receptor Kinase 3 is structurally similar to the SERK family of co-receptors.
Q27703723The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer
Q36050050The MLLE domain of the ubiquitin ligase UBR5 binds to its catalytic domain to regulate substrate binding
Q29620199The Phenix software for automated determination of macromolecular structures
Q27679914The Respiratory Arsenite Oxidase: Structure and the Role of Residues Surrounding the Rieske Cluster
Q27671838The Role of MukE in Assembling a Functional MukBEF Complex
Q27678286The Structure of Mlc Titration Factor A (MtfA/YeeI) Reveals a Prototypical Zinc Metallopeptidase Related to Anthrax Lethal Factor
Q27676647The TP0796 Lipoprotein of Treponema pallidum Is a Bimetal-dependent FAD Pyrophosphatase with a Potential Role in Flavin Homeostasis
Q27651629The Tim8–Tim13 Complex Has Multiple Substrate Binding Sites and Binds Cooperatively to Tim23
Q27670846The crystal structure of GXGD membrane protease FlaK
Q27645802The crystal structure of the tumor suppressor protein pp32 (Anp32a): Structural insights into Anp32 family of proteins
Q27684613The lab oddity prevails: discovery of pan-CDK inhibitor (R)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the treatment of cancer
Q33552183The minimum crystal size needed for a complete diffraction data set.
Q27648318The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin
Q27646404The novel 2Fe–2S outer mitochondrial protein mitoNEET displays conformational flexibility in its N-terminal cytoplasmic tethering domain
Q53826628The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone.
Q27659007The quorum-quenching N-acyl homoserine lactone acylase PvdQ is an Ntn-hydrolase with an unusual substrate-binding pocket
Q34339082The role of biotin and oxamate in the carboxyltransferase reaction of pyruvate carboxylase
Q27683292The role of distant mutations and allosteric regulation on LovD active site dynamics
Q27666843The structural basis for tight control of PP2A methylation and function by LCMT-1.
Q27640534The structure and thermal motion of the B800-850 LH2 complex from Rps.acidophila at 2.0A resolution and 100K: new structural features and functionally relevant motions
Q27644323The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function
Q27664998The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes
Q27644121The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator
Q27644228The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae , reveals an OB-fold
Q27644146The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role
Q27649417The structure of a DnaB-family replicative helicase and its interactions with primase
Q27657634The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.
Q27684254The structure of brazzein, a sweet-tasting protein from the wild African plant Pentadiplandra brazzeana
Q100634478The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics
Q27644193The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism
Q27644101The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation
Q35180572Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein
Q38760720Toremifene interacts with and destabilizes the Ebola virus glycoprotein
Q37695608Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1.
Q27679224Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code
Q27678241Triosephosphate isomerase is a common crystallization contaminant of soluble His-tagged proteins produced inEscherichia coli
Q27660323Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model
Q27684643Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions
Q27678841Unusual base pairing during the decoding of a stop codon by the ribosome
Q27657923Use of thallium to identify monovalent cation binding sites in GroEL
Q57050902Using sound pulses to solve the crystal-harvesting bottleneck
Q29618169Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein
Q27657376X-ray Crystal Structure of Michaelis Complex of Aldoxime Dehydratase
Q27681891X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
Q36010062X-ray diffraction analysis and molecular-replacement solution of the cyan fluorescent protein dsFP483
Q29619405X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution
Q27668110cDNA Sequence and Fab Crystal Structure of HL4E10, a Hamster IgG Lambda Light Chain Antibody Stimulatory for γδ T Cells

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