Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.

scientific article

Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M706384200
P8608Fatcat IDrelease_qorzxmgp75hrtmmrobr5mpzrka
P3181OpenCitations bibliographic resource ID1644509
P698PubMed publication ID17977840

P2093author name stringAntonio Bedalov
Jessica Kim
Safia Thaminy
Benjamin Newcomb
Julian Simon
Eric Foss
Tonibelle Gatbonton
P2860cites workYeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56Q24633791
Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II.Q27930864
Identification of protein complexes required for efficient sister chromatid cohesionQ27931376
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.Q27931475
Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Q27931822
Mrc1 transduces signals of DNA replication stress to activate Rad53.Q27935521
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replicationQ27935707
Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damageQ27936447
Acetylation in histone H3 globular domain regulates gene expression in yeast.Q27937002
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stabilityQ27937288
The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.Q27937957
Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosisQ27938401
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complexQ27938718
Identification of a small molecule inhibitor of Sir2pQ28344005
Rapid and reliable protein extraction from yeastQ29617781
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction mapQ29618911
Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiaeQ33226323
Characterization of lysine 56 of histone H3 as an acetylation site in Saccharomyces cerevisiaeQ34418079
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response.Q34433751
The DNA damage response during DNA replicationQ34561760
Histone deposition at the replication fork: a matter of urgencyQ35079236
Is Rad9p upstream or downstream from Mec1p?Q35132574
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.Q35966662
The biochemistry of sirtuins.Q36498332
S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesionQ37220712
Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexesQ42850451
Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.Q43796805
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiaeQ46200700
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.Q53662825
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
NAD-dependent histone deacetylase HST3 YOR025WQ27547447
P304page(s)37805-14
P577publication date2007-12-28
P1433published inJournal of Biological ChemistryQ867727
P1476titleHst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.
P478volume282

Reverse relations

cites work (P2860)
Q36574588A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae
Q42695520A negatively charged residue in place of histone H3K56 supports chromatin assembly factor association but not genotoxic stress resistance
Q43217577Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair
Q34808805Acetylation of Chromatin-Associated Histone H3 Lysine 56 Inhibits the Development of Encysted Artemia Embryos
Q41846871Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast
Q33386002Cell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeast
Q36775512Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress
Q37110964Clothing up DNA for all seasons: Histone chaperones and nucleosome assembly pathways
Q37822707Double-strand breaks and the concept of short- and long-term epigenetic memory.
Q41028053Environmental change drives accelerated adaptation through stimulated copy number variation
Q36442657Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation
Q26744570Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress
Q36954157HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin
Q36836967Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage
Q24612284Histone H3 lysine 56 acetylation and the response to DNA replication fork damage
Q27003952Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases
Q27936956Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiae
Q37725290Hst3 is turned over by a replication stress-responsive SCF(Cdc4) phospho-degron
Q43065335Hst3p, a histone deacetylase, promotes maintenance of Saccharomyces cerevisiae chromosome III lacking efficient replication origins.
Q35113399Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis
Q35111126Identification of a replication-independent replacement histone H3 in the basidiomycete Ustilago maydis
Q35579790Interplay between histone H3 lysine 56 deacetylation and chromatin modifiers in response to DNA damage.
Q33940382Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy
Q34013667Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.
Q39488135Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases
Q38321688Oncogene Ras/phosphatidylinositol 3-kinase signaling targets histone H3 acetylation at lysine 56.
Q33879989Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae
Q36724337Proliferating cell nuclear antigen and ASF1 modulate silent chromatin in Saccharomyces cerevisiae via lysine 56 on histone H3.
Q37676224Regulation of Replication Fork Advance and Stability by Nucleosome Assembly.
Q39999393Regulation of the histone deacetylase Hst3 by cyclin-dependent kinases and the ubiquitin ligase SCFCdc4.
Q33727077Regulation of white and opaque cell-type formation in Candida albicans by Rtt109 and Hst3
Q91291846Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
Q38725407Rtt101-Mms1-Mms22 coordinates replication-coupled sister chromatid cohesion and nucleosome assembly
Q42146739Sirtuins at the breaking point: SIRT6 in DNA repair
Q52605047Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry.
Q33769550The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators
Q57753635The Main Role of Srs2 in DNA Repair Depends on Its Helicase Activity, Rather than on Its Interactions with PCNA or Rad51
Q30493921The Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractions
Q37580933The S-phase checkpoint: targeting the replication fork
Q34561974The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe
Q34947832The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation
Q42021677Transcriptional regulation by Asf1: new mechanistic insights from studies of the DNA damage response to replication stress
Q37398613Untargeted tail acetylation of histones in chromatin: lessons from yeast

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