Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis

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Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis is …
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P356DOI10.1371/JOURNAL.PGEN.1004990
P932PMC publication ID4338291
P698PubMed publication ID25705897
P5875ResearchGate publication ID272749391

P2093author name stringSang Eun Lee
Kyungjae Myung
Stephanie Smith
Jun Che
Eun Yong Shim
Yoo Jung Kim
P2860cites workHistone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNAQ24306661
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeQ24548535
Histone H3 lysine 56 acetylation and the response to DNA replication fork damageQ24612284
Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56Q24633791
CBP/p300-mediated acetylation of histone H3 on lysine 56Q24657910
Structural characterization of H3K56Q nucleosomes and nucleosomal arraysQ27659174
Rtt109 prevents hyper-amplification of ribosomal RNA genes through histone modification in budding yeastQ27929531
Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Q27929966
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.Q27930164
Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.Q27931196
Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assemblyQ27932260
Migrating bubble during break-induced replication drives conservative DNA synthesisQ27932674
Break-induced replication and telomerase-independent telomere maintenance require Pol32.Q27933035
Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.Q27934708
The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaksQ27934796
Increased mutagenesis and unique mutation signature associated with mitotic gene conversionQ27934880
Mrc1 transduces signals of DNA replication stress to activate Rad53.Q27935521
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replicationQ27935707
Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.Q27936302
Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediatesQ27936561
Acetylation in histone H3 globular domain regulates gene expression in yeast.Q27937002
Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrityQ27937011
The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends.Q27937088
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stabilityQ27937288
The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.Q27937957
Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosisQ27938401
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complexQ27938718
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.Q27939003
A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzymeQ27940293
Break-induced replication and recombinational telomere elongation in yeastQ28244552
A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stabilityQ28534685
Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatidQ28563892
Elevated Histone Expression Promotes Life Span ExtensionQ28660674
Double strand break repair functions of histone H2AXQ28661754
Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damageQ29614221
The DNA replication checkpoint response stabilizes stalled replication forksQ29618306
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction mapQ29618911
Cell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeastQ33386002
Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targetingQ33582128
Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome endsQ33594452
Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replicationQ33632172
Break-induced replication is highly inaccurateQ33828325
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response.Q34433751
Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability.Q35143822
A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.Q35949908
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.Q35966662
Microhomology directs diverse DNA break repair pathways and chromosomal translocationsQ36384380
Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancerQ36692800
Chromatin challenges during DNA replication and repairQ36744476
Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation.Q36752456
Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damageQ36836967
Defective break-induced replication leads to half-crossovers in Saccharomyces cerevisiaeQ36836996
HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatinQ36954157
Nucleosome dynamics regulates DNA processingQ37011985
Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is completeQ37078952
Break-induced replication occurs by conservative DNA synthesisQ37103994
Break-induced replication: what is it and what is it for?Q37138963
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.Q37164089
Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration.Q37558760
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylationQ40097842
Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activityQ41493782
Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeresQ42734454
Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpointQ43125336
A recombination execution checkpoint regulates the choice of homologous recombination pathway during DNA double-strand break repairQ43172930
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repairQ43217577
Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.Q43796805
Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicaseQ44111120
Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiaeQ46200700
Rapid depletion of budding yeast proteins by fusion to a heat-inducible degronQ47976542
Template switching during break-induced replicationQ56521356
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue2
P304page(s)e1004990
P577publication date2015-02-23
P1433published inPLOS GeneticsQ1893441
P1476titleHyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis
P478volume11