| Q55083283 | A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress. |
| Q36214221 | A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression |
| Q27933133 | A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae |
| Q33535179 | A proteome-wide analysis of kinase-substrate network in the DNA damage response |
| Q34621011 | A role for CDK9-cyclin K in maintaining genome integrity |
| Q37496789 | A role for Saccharomyces cerevisiae Chk1p in the response to replication blocks |
| Q43514051 | A study of the DNA damage checkpoint in Candida albicans: uncoupling of the functions of Rad53 in DNA repair, cell cycle regulation and genotoxic stress-induced polarized growth |
| Q33522877 | A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae |
| Q44838357 | ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thaliana |
| Q41907319 | Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae |
| Q40960095 | Activation of Dun1 in response to nuclear DNA instability accounts for the increase in mitochondrial point mutations in Rad27/FEN1 deficient S. cerevisiae |
| Q31156501 | Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae |
| Q36119385 | An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth |
| Q35222318 | Analyzing the dose-dependence of the Saccharomyces cerevisiae global transcriptional response to methyl methanesulfonate and ionizing radiation |
| Q44384757 | Anti-cancer drug KP1019 modulates epigenetics and induces DNA damage response in Saccharomyces cerevisiae |
| Q27024636 | Antimutator variants of DNA polymerases |
| Q28541434 | Assessment of the biological pathways targeted by isocyanate using N-succinimidyl N-methylcarbamate in budding yeast Saccharomyces cerevisiae |
| Q35064490 | Better chemistry for better survival, through regulation |
| Q38206208 | Biology of telomeres: lessons from budding yeast |
| Q33828325 | Break-induced replication is highly inaccurate |
| Q35347521 | Break-induced replication requires DNA damage-induced phosphorylation of Pif1 and leads to telomere lengthening. |
| Q34570125 | Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae |
| Q36881426 | Cell cycle regulation of DNA replication. |
| Q97876574 | Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition |
| Q35006441 | Checking on the fork: the DNA-replication stress-response pathway |
| Q47650967 | Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress |
| Q43110805 | Checkpoint-dependent RNR induction promotes fork restart after replicative stress |
| Q33888520 | Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage |
| Q35616094 | Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity |
| Q27932089 | Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. |
| Q35100574 | Coordination of DNA synthesis and replicative unwinding by the S-phase checkpoint pathways. |
| Q39895340 | Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms |
| Q34611390 | Cotransport of the heterodimeric small subunit of the Saccharomyces cerevisiae ribonucleotide reductase between the nucleus and the cytoplasm |
| Q34324101 | Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast |
| Q37417534 | Cytoplasmic localization of Hug1p, a negative regulator of the MEC1 pathway, coincides with the compartmentalization of Rnr2p-Rnr4p |
| Q24815044 | DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. |
| Q37056627 | DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants |
| Q36488090 | DNA damage checkpoint, damage repair, and genome stability |
| Q24646336 | DNA damage signalling prevents deleterious telomere addition at DNA breaks |
| Q36085679 | Damage-induced phosphorylation of Sld3 is important to block late origin firing |
| Q35762655 | Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions |
| Q38572102 | Deoxyribonucleotide metabolism, mutagenesis and cancer |
| Q38220118 | Deoxyribonucleotides as genetic and metabolic regulators |
| Q43137350 | Determination of the in vivo stoichiometry of tyrosyl radical per betabeta' in Saccharomyces cerevisiae ribonucleotide reductase |
| Q33374228 | Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit |
| Q35633411 | Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase |
| Q39882599 | Drug-sensitive DNA polymerase δ reveals a role for mismatch repair in checkpoint activation in yeast. |
| Q33700062 | Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants |
| Q36643853 | Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast |
| Q35760007 | Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype |
| Q37956184 | Eukaryotic DNA damage checkpoint activation in response to double-strand breaks |
| Q33310471 | Excess single-stranded DNA inhibits meiotic double-strand break repair. |
| Q36691026 | Expression and maintenance of mitochondrial DNA: new insights into human disease pathology |
| Q42142499 | Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint |
| Q47987433 | Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis |
| Q36297194 | Functional analysis with a barcoder yeast gene overexpression system |
| Q64888640 | Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase. |
| Q24606805 | Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs |
| Q48197466 | GSK-3β Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2. |
| Q28264035 | Genetic instability in budding and fission yeast-sources and mechanisms |
| Q35294605 | H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly |
| Q34271790 | Hydroxyurea Arrests DNA Replication by a Mechanism That Preserves Basal dNTP Pools |
| Q27939432 | Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes. |
| Q31033545 | Identification of phosphorylation sites on the yeast ribonucleotide reductase inhibitor Sml1. |
| Q24650185 | Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response |
| Q39891002 | Inactivation of Ku-mediated end joining suppresses mec1Delta lethality by depleting the ribonucleotide reductase inhibitor Sml1 through a pathway controlled by Tel1 kinase and the Mre11 complex |
| Q35293714 | Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice |
| Q36338771 | Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response |
| Q40287019 | Induction ofS. cerevisiaeFilamentous Differentiation by Slowed DNA Synthesis Involves Mec1, Rad53 and Swe1 Checkpoint Proteins |
| Q90059577 | Inhibition of spindle extension through the yeast S phase checkpoint is coupled to replication fork stability and the integrity of centromeric DNA |
| Q27930202 | Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme |
| Q28478063 | Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools |
| Q28391868 | Limiting amounts of budding yeast Rad53 S-phase checkpoint activity results in increased resistance to DNA alkylation damage |
| Q27936718 | Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levels |
| Q34313399 | Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase |
| Q100946029 | Maximized quantitative phosphoproteomics allows high confidence dissection of the DNA damage signaling network |
| Q92416794 | Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats |
| Q37628254 | Mec1/ATR, the Program Manager of Nucleic Acids Inc. |
| Q33611684 | Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae. |
| Q37793347 | Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells |
| Q34609166 | Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools |
| Q36478038 | Mek1 stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during yeast meiosis |
| Q37878159 | Mind the gap: keeping UV lesions in check. |
| Q37122913 | Molecular basis of the essential s phase function of the rad53 checkpoint kinase |
| Q58884834 | Molecular targets for cell cycle inhibition and cancer therapy |
| Q38204290 | Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy. |
| Q36255286 | Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint |
| Q37748663 | Navigating the nucleotide excision repair threshold |
| Q27932046 | Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism. |
| Q27933722 | Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin |
| Q27932610 | Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae |
| Q27933989 | Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein |
| Q33302712 | On the detection of functionally coherent groups of protein domains with an extension to protein annotation |
| Q36668242 | Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas |
| Q38784684 | P53 suppresses ribonucleotide reductase via inhibiting mTORC1. |
| Q37499545 | Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae. |
| Q83520155 | Phenotypes associated with Saccharomyces cerevisiae Hug1 protein, a putative negative regulator of dNTP Levels, reveal similarities and differences with sequence-related Dif1 |
| Q37485516 | Prevention of DNA Rereplication Through a Meiotic Recombination Checkpoint Response |
| Q41002895 | Protein kinase C controls activation of the DNA integrity checkpoint. |
| Q35973264 | Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases |
| Q36780916 | RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibition |
| Q79745517 | RNR4 mutant alleles pso3-1 and rnr4Delta block induced mutation in Saccharomyces cerevisiae |
| Q39852750 | Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling |
| Q27930928 | Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress |
| Q33962242 | Recombinational repair and restart of damaged replication forks. |
| Q40817579 | Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms |
| Q41186025 | Regulators of ribonucleotide reductase inhibit Ty1 mobility in saccharomyces cerevisiae |
| Q41789965 | Replication checkpoint: tuning and coordination of replication forks in s phase |
| Q37156247 | Rpb1 sumoylation in response to UV radiation or transcriptional impairment in yeast |
| Q36529251 | S phase block following MEC1ATR inactivation occurs without severe dNTP depletion. |
| Q35794091 | SUMOylation regulates telomere length homeostasis by targeting Cdc13. |
| Q27933104 | Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae |
| Q89093963 | Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling |
| Q37971853 | Similarities and differences between "uncapped" telomeres and DNA double-strand breaks. |
| Q42962767 | Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage |
| Q89473917 | Sml1 Inhibits the DNA Repair Activity of Rev1 in Saccharomyces cerevisiae during Oxidative Stress |
| Q37085701 | Stimulation of sister chromatid exchanges and mutation by aflatoxin B1-DNA adducts in Saccharomyces cerevisiae requires MEC1 (ATR), RAD53, and DUN1 |
| Q34466516 | Structural basis and prediction of substrate specificity in protein serine/threonine kinases |
| Q27937332 | Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways |
| Q27939559 | Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance |
| Q44311904 | Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase |
| Q24805253 | Systematic quantification of gene interactions by phenotypic array analysis |
| Q27938358 | TOR signaling is a determinant of cell survival in response to DNA damage. |
| Q38089570 | The DNA damage checkpoint response to replication stress: A Game of Forks |
| Q37676255 | The Intra-S Checkpoint Responses to DNA Damage |
| Q36543289 | The Rad53 signal transduction pathway: Replication fork stabilization, DNA repair, and adaptation |
| Q42412042 | The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination |
| Q42209629 | The checkpoint transcriptional response: make sure to turn it off once you are satisfied. |
| Q41835998 | The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae |
| Q36688656 | The histone chaperone Asf1 at the crossroads of chromatin and DNA checkpoint pathways |
| Q42560984 | The intrinsically disordered RNR inhibitor Sml1 is a dynamic dimer |
| Q27930520 | The mutation of a novel Saccharomyces cerevisiae SRL4 gene rescues the lethality of rad53 and lcd1 mutations by modulating dNTP levels |
| Q42137830 | The non-homologous end-joining protein Nej1p is a target of the DNA damage checkpoint |
| Q27929838 | The protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyurea |
| Q38257019 | The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. |
| Q34246788 | The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage |
| Q30596955 | The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence |
| Q30479667 | The yeast DNA damage checkpoint proteins control a cytoplasmic response to DNA damage |
| Q42134963 | Trm9-catalyzed tRNA modifications link translation to the DNA damage response |
| Q27938725 | UV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools |
| Q58325845 | Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in |
| Q64246067 | Versatility of the Mec1 signaling network in mediating resistance to replication, genotoxic, and proteotoxic stresses |
| Q27931948 | Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Small Subunit Localization in Response to Iron Deficiency. |
| Q34056390 | Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron deficiency |
| Q35616117 | dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants |
| Q41166217 | dNTP pools determine fork progression and origin usage under replication stress |