Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins

scientific article

Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.15.3.1333
P932PMC publication ID230357
P698PubMed publication ID7532279
P5875ResearchGate publication ID254741732

P50authorMichael WiglerQ6835334
P2093author name stringL Chen
S Powers
S L Hofmann
V Jung
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteinsQ24324729
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition methodQ24631695
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A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiaeQ27860636
A novel genetic system to detect protein-protein interactionsQ27860915
Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteinsQ27931397
The Ras superfamilies: regulatory proteins and post-translational modificationsQ37353344
Acylation and prenylation of proteinsQ37803776
N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localizationQ38306703
The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclaseQ38322279
RSR1, a ras-like gene homologous to Krev-1 (smg21A/rap1A): role in the development of cell polarity and interactions with the Ras pathway in Saccharomyces cerevisiaeQ40654206
A novel yeast mutant defective in the processing of ras proteins: assessment of the effect of the mutation on processing stepsQ41331407
Characterization of an acyltransferase acting on p21N-ras protein in a cell-free system.Q41678865
Common modifications of trimeric G proteins and ras protein: involvement of polyisoprenylationQ42041959
Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras proteinQ42633543
Immunogenic structure of the influenza virus hemagglutininQ45805278
Protein prenylation: a modification that sticksQ47981682
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathwayQ48348054
The p21 ras C-terminus is required for transformation and membrane associationQ53551139
Genetic analysis of mammalian GAP expressed in yeast.Q54722400
New clue to Ras lipid glueQ59047398
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factorQ68907725
Studies of RAS function in the yeast Saccharomyces cerevisiaeQ70267173
Protein prenylation: a mediator of protein-protein interactionsQ70619096
A polybasic domain allows nonprenylated Ras proteins to function in Saccharomyces cerevisiaeQ72136028
SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunitsQ27931473
Genetic analysis of yeast RAS1 and RAS2 genes.Q27932104
S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein.Q27932353
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiaeQ27932763
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiaeQ27933331
DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclaseQ27934829
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinaseQ27935548
RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteinsQ27936473
In yeast, RAS proteins are controlling elements of adenylate cyclase.Q27939207
Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathwayQ27939940
Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated proteinQ27940176
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sitesQ28131597
One-step gene disruption in yeastQ28131598
All ras proteins are polyisoprenylated but only some are palmitoylatedQ28270312
The structure of an antigenic determinant in a proteinQ29547829
Transformation in yeast: development of a hybrid cloning vector and isolation of the CAN1 geneQ29547924
Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkersQ29620747
[12] One-step gene disruption in yeastQ29642800
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysisQ33562770
Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiaeQ33879414
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteinsQ33924487
Dynamic fatty acylation of p21N-rasQ33929812
Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.Q34257307
The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G proteinQ34446061
Functional homology of mammalian and yeast RAS genes.Q34563916
Prenoids and palmitate: lipids that control the biological activity of Ras proteinsQ35464107
Protein prenylation: genes, enzymes, targets, and functions.Q35656726
Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiaeQ36765220
Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras proteinQ36816986
Fatty acylation is important but not essential for Saccharomyces cerevisiae RAS functionQ36843110
Direct identification of palmitic acid as the lipid attached to p21rasQ36908523
Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene familyQ36922463
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activityQ37108753
Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.Q37345629
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
Shr5p YOL110WQ27552623
P304page(s)1333-42
P577publication date1995-03-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleMutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins
P478volume15

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cites work (P2860)
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