James C Whisstock

structural biologist

James C Whisstock is …
instance of (P31):
humanQ5

External links are
P8179Canadiana Name Authority IDncf11610423
P2456DBLP author ID49/5583
P1960Google Scholar author IDAtclWv4AAAAJ
P269IdRef ID154778524
P213ISNI0000000122674821
P244Library of Congress authority IDno2011112810
P8189National Library of Israel J9U ID987007332718905171
P1006Nationale Thesaurus voor Auteursnamen ID334422434
P1315NLA Trove people ID1709564
P1207NUKAT IDn2011055928
P856official websitehttps://research.monash.edu/en/persons/d2afe85c-0d13-4da3-aaa1-8a53a054a118
P496ORCID iD0000-0003-4200-5611
P3065RERO ID (obsolete)02-A019083483
P1153Scopus author ID56247908700
P214VIAF ID172544423
P10832WorldCat Entities IDE39PCjvmyMRrBjqp8Cc4K739fy

P166award receivedGottschalk MedalQ5588086
P69educated atUniversity of CambridgeQ35794
P108employerMonash UniversityQ598841
P734family nameWhisstockQ121437845
WhisstockQ121437845
WhisstockQ121437845
P735given nameJamesQ677191
JamesQ677191
P106occupationstructural biologistQ84505215
P21sex or gendermaleQ6581097

Reverse relations

author (P50)
Q27677421A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4
Q27647495A common fold mediates vertebrate defense and bacterial attack
Q27321259A new model for pore formation by cholesterol-dependent cytolysins
Q34785379A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2.
Q27649735A structural basis for loop C-sheet polymerization in serpins
Q27640322A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity
Q38149466A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
Q36351013A versatile monoclonal antibody specific to human SERPINB5
Q53595113AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.
Q34652212Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap
Q50212903An Essential Role of Maspin in Embryogenesis and Tumor Suppression-Letter.
Q41736938An atlas of serpin conformations.
Q24684030An overview of the serpin superfamily
Q49235374An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy
Q36407319Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding
Q101575486Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector
Q36249909Antibodies: From novel repertoires to defining and refining the structure of biologically important targets.
Q35612476Antithrombin: in control of coagulation
Q57079380Assembling the machinery of coagulation
Q30408074Automatic generation of protein structure cartoons with Pro-origami
Q27671783Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
Q37844034Bioinformatic approaches for predicting substrates of proteases
Q53504215Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development.
Q27322895Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density
Q57079437CLIMS: Crystallography Laboratory Information Management System
Q57079408COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity
Q57079378Capturing embryonic development from metamorphosis: how did the terminal patterning signalling pathway of Drosophila evolve?
Q47837736Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets
Q43174713Cascleave: towards more accurate prediction of caspase substrate cleavage sites
Q33925076Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells
Q30042214Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice
Q33932541Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity
Q57079453Characterization of epitope regions of thyrotropin β-subunit recognized by the monoclonal antibodies mAb279 and mAb299: a chimeric peptide approach
Q44608196Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes
Q24672272Cleaved antitrypsin polymers at atomic resolution
Q34943452Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.
Q48213232Computational analysis of evolution and conservation in a protein superfamily
Q33415482Conformational change in the chromatin remodelling protein MENT
Q27313232Conformational changes during pore formation by the perforin-related protein pleurotolysin
Q57079448Conformational changes in serpins: I. the native and cleaved conformations of α 1 -antitrypsin 1 1Edited by J. M. Thornton
Q33916072Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.
Q57079460Conservation within the myosin motor domain: implications for structure and function
Q36824107Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.
Q58028932Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3
Q33707312Crystallization of the virulent and benign subtilisin-like proteases from the ovine footrot pathogen Dichelobacter nodosus
Q51763918Crystallography of serpins and serpin complexes.
Q34007408DNA accelerates the inhibition of human cathepsin V by serpins
Q27686809Defining the interaction of perforin with calcium and the phospholipid membrane
Q30874190Determination of the P1', P2' and P3' subsite-specificity of factor Xa.
Q39479462Development of the Cellular Immune System of Drosophila Requires the Membrane Attack Complex/Perforin-Like Protein Torso-Like
Q48199620EGM: encapsulated gene-by-gene matching to identify gene orthologs and homologous segments in genomes
Q35860618Efficient large-scale protein sequence comparison and gene matching to identify orthologs and co-orthologs
Q33223538Elucidation of the substrate specificity of the C1s protease of the classical complement pathway
Q33294670Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
Q33958456Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases
Q33345190Federated repositories of X-ray diffraction images
Q34168471Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum
Q35046397Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence
Q33736258Functional insights from the distribution and role of homopeptide repeat-containing proteins
Q27644229GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop
Q49832688Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway
Q38647638Giant MACPF/CDC pore forming toxins: A class of their own.
Q35539708GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome
Q35131686Glycoprotein Ib-IX-V.
Q27683525High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster
Q57079396Highlight: The Biology of Proteolytic Systems
Q56917400Hijacking of a Substrate-binding Protein Scaffold for use in Mycobacterial Cell Wall Biosynthesis
Q57079372Homodimerization attenuates the anti-inflammatory activity of interleukin-37
Q35652972Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.
Q24305291Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis
Q31967214IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes.
Q28258076IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
Q24292896Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles ...
Q43559280Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop
Q33195942Importance of the prime subsites of the C1s protease of the classical complement pathway for recognition of substrates
Q30804202Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation
Q44561956Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability
Q51806809Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor.
Q33553223MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography
Q51190031MUSTANG: a multiple structural alignment algorithm.
Q31018502Managing and mining protein crystallization data.
Q24634632Maspin (SERPINB5) is an obligate intracellular serpin
Q24612315Maspin is not required for embryonic development or tumour suppression
Q38790905Maternal Torso-Like Coordinates Tissue Folding During Drosophila Gastrulation
Q34589048Mechanisms of serpin dysfunction in disease.
Q27680739Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1
Q30370262Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders.
Q71856538Modeling of serpin-protease complexes: antithrombin-thrombin, alpha 1-antitrypsin (358Met-->Arg)-thrombin, alpha 1-antitrypsin (358Met-->Arg)-trypsin, and antitrypsin-elastase
Q45971313Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1.
Q24337646Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer
Q42929194Molecular contortionism - on the physical limits of serpin 'loop-sheet' polymers
Q40749760Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide
Q34000643Molecular gymnastics: serpin structure, folding and misfolding
Q33553231MrGrid: a portable grid based molecular replacement pipeline
Q30785263Multiple alignment and sorting of peptides derived from phage-displayed random peptide libraries with polyclonal sera allows discrimination of relevant phagotopes
Q38711306N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin
Q38164155New insights into the structure and function of the plasminogen/plasmin system.
Q34500105PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites
Q38496608Perforin and granzymes: function, dysfunction and human pathology
Q34253572Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi
Q44770736Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
Q50129807Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Q38652776Perforin-A key (shaped) weapon in the immunological arsenal.
Q34620426Perforin: structure, function, and role in human immunopathology
Q54977796PhosContext2vec: a distributed representation of residue-level sequence contexts and its application to general and kinase-specific phosphorylation site prediction.
Q33928073Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.
Q37606793Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
Q51369996PoPS: a computational tool for modeling and predicting protease specificity.
Q30155348Predicting giant transmembrane β-barrel architecture
Q34073203Predicting serpin/protease interactions
Q33976748Prediction of protein function from protein sequence and structure
Q40883950Preferential Acquisition and Activation of Plasminogen Glycoform II by PAM Positive Group A Streptococcal Isolates.
Q43942603Probing the role of the F-helix in serpin stability through a single tryptophan substitution
Q52534363Probing the unfolding pathway of alpha1-antitrypsin.
Q21142748Prodepth: predict residue depth by support vector regression approach from protein sequences only
Q51562730Progressive multiple alignment using sequence triplet optimizations and three-residue exchange costs.
Q38011488Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death
Q39527555Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes
Q27331221RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly
Q35854840RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins
Q42667386REFOLD: an analytical database of protein refolding methods
Q40343450Real-time visualization of perforin nanopore assembly.
Q27683425Reconciling the Structural Attributes of Avian Antibodies
Q47952775Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation
Q54519784Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT.
Q27674974S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction
Q34636554SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change
Q30175759SH3 domains in prokaryotes
Q24338773SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes
Q46714514Serpins 2005 - fun between the beta-sheets. Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia).
Q24597270Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems
Q24597208Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions
Q57079410Serpins' mystery solved
Q34974665Serpins: finely balanced conformational traps
Q37282499Smoothing a rugged protein folding landscape by sequence-based redesign
Q35586527Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase
Q36394195Stonefish toxin defines an ancient branch of the perforin-like superfamily.
Q28266624Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes
Q27676177Structural and Functional Analysis of the Pore-Forming Toxin NetB from Clostridium perfringens
Q57079439Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3
Q27653672Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
Q54714680Structural biology: Torqueing about pores.
Q27674978Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates
Q39943963Structural determinants of GAD antigenicity
Q47575939Structural insights into multi-protein communication systems
Q27655427Structural mechanisms of inactivation in scabies mite serine protease paralogues
Q27654213Structure of granzyme C reveals an unusual mechanism of protease autoinhibition
Q27659580Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
Q28115911Structure of the poly-C9 component of the complement membrane attack complex
Q44203934Subunit gamma-green fluorescent protein fusions are functionally incorporated into mitochondrial F1F0-ATP synthase, arguing against a rigid cap structure at the top of F1.
Q27667128Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 Metalloaminopeptidase
Q40368484T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide
Q40913192TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens
Q37239059Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer
Q27640892The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment
Q27643380The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis
Q27734997The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site
Q34462442The AprV5 subtilase is required for the optimal processing of all three extracellular serine proteases from Dichelobacter nodosus.
Q27673121The Extracellular Protein Factor Epf from Streptococcus pyogenes Is a Cell Surface Adhesin That Binds to Cells through an N-terminal Domain Containing a Carbohydrate-binding Module
Q30736622The FxRxHrS motif: a conserved region essential for DNA binding of the VirR response regulator from Clostridium perfringens
Q30157659The MACPF/CDC family of pore-forming toxins
Q24681654The N terminus of the serpin, tengpin, functions to trap the metastable native state
Q35978229The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells
Q25255516The REFOLD database: a tool for the optimization of protein expression and refolding
Q47614108The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.
Q27666157The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates
Q27681123The Three-dimensional Structure of the Extracellular Adhesion Domain of the Sialic Acid-binding Adhesin SabA fromHelicobacter pylori
Q27659983The X-Ray Crystal Structure of Escherichia coli Succinic Semialdehyde Dehydrogenase; Structural Insights into NADP+/Enzyme Interactions
Q27678744The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome
Q27681852The X-ray crystal structure of full-length human plasminogen
Q27676030The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria
Q27650111The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism
Q50079513The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase.
Q44577217The evolution of enzyme specificity in Fasciola spp.
Q57651515The first transmembrane region of complement component-9 acts as a brake on its self-assembly
Q34375148The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition
Q42650519The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix
Q36519309The human serpin proteinase inhibitor-9 self-associates at physiological temperatures
Q24682724The major human and mouse granzymes are structurally and functionally divergent
Q57079434The matrix refolded
Q39850780The molecular basis for perforin oligomerization and transmembrane pore assembly
Q34448263The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins
Q37691703The perforin pore facilitates the delivery of cationic cargos
Q28364511The role of strand 1 of the C beta-sheet in the structure and function of alpha(1)-antitrypsin
Q43894620The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases
Q29618777The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature
Q27665482The structural basis for membrane binding and pore formation by lymphocyte perforin
Q34644375The structure and function of catalytic domains within inositol polyphosphate 5-phosphatases.
Q37791183The structure and function of mammalian membrane-attack complex/perforin-like proteins.
Q27644771The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family
Q33582255The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.
Q24523405The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
Q50324222The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome.
Q27940135The yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail: regulation of secretion from the endoplasmic reticulum.
Q57079444Thermal Unfolding of Proteins Studied by Coupled Reversed-Phase HPLC−Electrospray Ionization Mass Spectrometry Techniques Based on Isotope Exchange Effects
Q50422650Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signalling Pathway in Drosophila
Q37157370Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing
Q36266903Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini
Q62472376Tranexamic acid is an active site inhibitor of urokinase plasminogen activator
Q52766958Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like.
Q27681227X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP
Q24550849X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation
Q57079373X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors
Q27649233X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin
Q24623471X-ray crystal structure of the streptococcal specific phage lysin PlyC.
Q49046548alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization
Q57079459α1-Antitrypsin Polymerisation Can Occur by both Loop A and C Sheet Mechanisms

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