The Role and Application of Sirtuins and mTOR Signaling in the Control of Ovarian Functions

scientific article

The Role and Application of Sirtuins and mTOR Signaling in the Control of Ovarian Functions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/CELLS5040042
P932PMC publication ID5187526
P698PubMed publication ID27886120

P2093author name stringAlexander Sirotkin
P2860cites workFollicle-stimulating hormone increases tuberin phosphorylation and mammalian target of rapamycin signaling through an extracellular signal-regulated kinase-dependent pathway in rat granulosa cellsQ80351959
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian CarcinomaQ87262832
Expression and prognostic significance of SIRT1 in ovarian epithelial tumoursQ38495239
Down-regulation of SIRT3 promotes ovarian carcinoma metastasisQ38769032
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expressionQ38895424
SIRT3 positively regulates the expression of folliculogenesis- and luteinization-related genes and progesterone secretion by manipulating oxidative stress in human luteinized granulosa cells.Q38990132
PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activityQ39507948
Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylaseQ39598940
Role of Sirt3 in mitochondrial biogenesis and developmental competence of human in vitro matured oocytesQ40085610
Roles of SIRT1 in granulosa cell apoptosis during the process of follicular atresia in porcine ovaryQ41748816
Molecular cloning and characterization of porcine sirtuin genesQ42618557
Resveratrol protects against age-associated infertility in miceQ42713496
Pharmacological targeting of mammalian target of rapamycin inhibits ovarian granulosa cell tumor growthQ43683078
The involvement of SIRT1 and transcription factor NF-κB (p50/p65) in regulation of porcine ovarian cell function.Q44756063
Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation.Q46016975
The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signalingQ46262165
A putative mitotic checkpoint dependent on mTOR function controls cell proliferation and survival in ovarian granulosa cellsQ46752396
SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during agingQ46874733
Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age.Q47698388
Are sirtuins markers of ovarian aging?Q48568750
Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age.Q48603452
Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expressionQ48627105
SIRT1 negatively regulates the mammalian target of rapamycinQ21142655
Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and AgingQ27021755
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteinsQ28139564
Luteinizing hormone stimulates mammalian target of rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase: modulation of glycogen synthase kinase 3 and AMP-activated protein kinaseQ33874422
mTOR controls ovarian follicle growth by regulating granulosa cell proliferationQ33959304
Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary.Q34167144
Low-dose oral sirolimus and the risk of menstrual-cycle disturbances and ovarian cysts: analysis of the randomized controlled SUISSE ADPKD trialQ34446891
SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signalingQ34514886
Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinomaQ34810176
Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in miceQ35201164
Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatideQ36014371
Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathwayQ36113996
Janus-faced role of SIRT1 in tumorigenesisQ36403645
The ups and downs of SIRT1.Q37274584
PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1.Q37293979
Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.Q37554263
Dissecting the role of mTOR: lessons from mTOR inhibitorsQ37652233
A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1.Q37820658
Targeting mTOR: evaluating the therapeutic potential of resveratrol for cancer treatmentQ38070190
mTOR inhibitors and their clinical application in cervical, endometrial and ovarian cancers: a critical reviewQ38189901
PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an updateQ38259986
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)42
P577publication date2016-11-24
P1433published inCellsQ27724621
P1476titleThe Role and Application of Sirtuins and mTOR Signaling in the Control of Ovarian Functions
P478volume5

Reverse relations

Q58581478Activation of CREBZF Increases Cell Apoptosis in Mouse Ovarian Granulosa Cells by Regulating the ERK1/2 and mTOR Signaling Pathwayscites workP2860

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