SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

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SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1006876202
P356DOI10.1186/S13048-014-0097-Z
P932PMC publication ID4232623
P698PubMed publication ID25330910
P5875ResearchGate publication ID267273019

P2093author name stringXiao-Chun Chen
Li-Li Luo
Hong-Xia Zhang
Xing-Mei Zhang
Wei-Juan Liu
Yu-Cai Fu
Jin-Jie Xu
Xiao-Ling Zhou
Yan-Hong Ni
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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanismsQ24597989
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetesQ24645537
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanQ24649811
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseQ27860668
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.Q27931475
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegansQ28131824
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1Q28203762
Resveratrol is not a direct activator of SIRT1 enzyme activityQ28261917
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversificationQ28512492
The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in ratsQ28574694
Estrous cycle regulation of mammary epithelial cell proliferation, differentiation, and death in the Sprague-Dawley rat: a model for investigating the role of estrous cycling in mammary carcinogenesisQ28576222
SIRT1 transgenic mice show phenotypes resembling calorie restrictionQ29301793
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013Q29616834
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient miceQ29619786
Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice.Q30375576
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese HumansQ32774312
Sirt1 deficiency attenuates spermatogenesis and germ cell functionQ33319556
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivoQ33417863
Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotesQ33559715
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride SynthesisQ34112535
Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspringQ34132433
Role of growth factors in ovary organogenesisQ34164802
Successful weight loss maintenanceQ34262917
Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese womenQ34372157
Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetesQ35060170
High fat diet affects reproductive functions in female diet-induced obese and dietary resistant ratsQ35899156
Direct effects of sex steroid hormones on adipose tissues and obesityQ35905509
Obesity and reproduction: impact and interventionsQ36877810
Dynamic FoxO transcription factorsQ36889897
SIRT1 genetic variation is related to BMI and risk of obesityQ37429176
Molecular mechanisms underlying the activation of mammalian primordial follicles.Q37546530
Sirtuins and p53.Q37548942
Impact of obesity on gynecologyQ37678420
Resveratrol, obesity and diabetes.Q37715352
Resveratrol and cardiovascular healthQ37788325
Inflammatory pathways linking obesity and ovarian dysfunctionQ37844732
New concepts in human sperm-zona pellucida interactionQ38290761
Ovulation as an inflammatory reaction--a hypothesisQ40284097
The impact of obesity on hyperandrogenism and polycystic ovary syndrome in premenopausal womenQ40833593
Resveratrol protects against age-associated infertility in miceQ42713496
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthmaQ42715351
Effects of plant polyphenols on ovarian follicular reserve in aging ratsQ42961669
Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles.Q43258123
Influences of age and ovarian follicular reserve on estrous cycle patterns, ovulation, and hormone secretion in the Long-Evans rat.Q43547956
Postprandial cytokine concentrations and meal composition in obese and lean women.Q46136920
Changing eating behaviour vs. losing weight: the role of goal focus for weight loss in overweight womenQ47371383
Obesity accelerates ovarian follicle development and follicle loss in ratsQ48616107
Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expressionQ48627105
Effects of tea polyphenols on ovarian development in ratsQ48725477
Influence of p53 and genetic background on prenatal oogenesis and oocyte attrition in miceQ48726029
Effect of increased body mass index on oocyte and embryo quality in IVF patients.Q48771739
Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female pubertyQ48938552
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectlifetimeQ22675021
obesityQ12174
P304page(s)97
P577publication date2014-10-21
P1433published inJournal of Ovarian ResearchQ27721898
P1476titleSIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling
P478volume7

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