Molecular mechanisms of chemoresistance in gastric cancer

scientific article

Molecular mechanisms of chemoresistance in gastric cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.4251/WJGO.V8.I9.673
P3181OpenCitations bibliographic resource ID3734000
P932PMC publication ID5027022
P698PubMed publication ID27672425

P2093author name stringJin-Bo Gao
Wen-Jia Shi
P2860cites workMutations of PIK3CA in gastric adenocarcinomaQ21261219
Global cancer statisticsQ22241238
IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cellsQ24310103
Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapyQ24635408
Mitogen-activated protein kinase signaling pathway and invasion and metastasis of gastric cancerQ26778022
Alterations of the TP53 gene in gastric and esophageal carcinogenesisQ26866191
Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancerQ27824834
Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysisQ27852996
miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cellsQ28278471
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancerQ29619394
Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate dataQ31044850
Activation of Akt and ERK signalling pathways induced by etoposide confer chemoresistance in gastric cancer cellsQ33235983
Gene expression of 5-fluorouracil metabolic enzymes in primary gastric cancer: correlation with drug sensitivity against 5-fluorouracilQ33274007
Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cellsQ33394070
LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cellsQ33655676
Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaBQ33656653
Distribution of basement membrane antigens in clinical gastric adenocarcinomas: an immunohistochemical studyQ33838435
Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxelQ33903541
Expression of multidrug resistance-associated proteins and their relation to postoperative individualized chemotherapy in gastric cancerQ34346821
MGr1-Ag/37LRP induces cell adhesion-mediated drug resistance through FAK/PI3K and MAPK pathway in gastric cancerQ35051795
Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cellsQ35061283
TP53 and gastric carcinoma: a reviewQ35078746
Drug resistance and the microenvironment: nature and nurtureQ35214616
Inhibition of the p38 MAPK pathway sensitizes human gastric cells to doxorubicin treatment in vitro and in vivoQ35290113
Expression of P-glycoprotein mRNA in human gastric tumorsQ35574352
Thymidylate synthase and thymidine phosphorylase gene expression as predictive parameters for the efficacy of 5-fluorouracil-based adjuvant chemotherapy for gastric cancer.Q35615776
Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loopQ35741610
Immunohistochemical study of DNA topoisomerase II in human gastric disordersQ35782052
Palliative chemotherapy for advanced gastric cancerQ35936039
Activation of AKT kinases in cancer: implications for therapeutic targetingQ36226730
Chemotherapy versus support cancer treatment in advanced gastric cancer: a meta-analysisQ36448352
Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancerQ36450457
miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancerQ36525110
Reduced tau expression in gastric cancer can identify candidates for successful Paclitaxel treatmentQ36614476
Correlation between chemosensitivity to anticancer drugs and Bcl-2 expression in gastric cancerQ37277833
Expression of multidrug resistance-associated protein1,P-glycoprotein, and thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resectionQ37352734
The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancerQ37458683
NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cellsQ38358712
Mitochondria-Judges and Executioners of Cell Death SentencesQ38760561
Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistanceQ38877475
IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistanceQ38890440
3β-Acetyl tormentic acid reverts MRP1/ABCC1 mediated cancer resistance through modulation of intracellular levels of GSH and inhibition of GST activityQ38967176
Gastric cancer cell adhesion to laminin enhances acquired chemotherapeutic drug resistance mediated by MGr1-Ag/37LRP.Q38993785
Extracellular high mobility group box chromosomal protein 1 promotes drug resistance by increasing the expression of P‑glycoprotein expression in gastric adenocarcinoma cellsQ39022862
rAd-p53 enhances the sensitivity of human gastric cancer cells to chemotherapyQ39062896
MicroRNA-106a induces multidrug resistance in gastric cancer by targeting RUNX3.Q39112720
MK-2206, an Akt inhibitor, enhances carboplatinum/paclitaxel efficacy in gastric cancer cell linesQ39115033
miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1.Q39119238
Bcl-2 gene silence enhances the sensitivity toward 5-Fluorouracil in gastric adenocarcinoma cellsQ39150533
Overexpression of AKT decreases the chemosensitivity of gastric cancer cells to cisplatin in vitro and in vivoQ39172858
Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxelQ39191770
Mechanism of P-glycoprotein expression in the SGC7901 human gastric adenocarcinoma cell line induced by cyclooxygenase-2.Q39295836
Overexpression of interferon regulatory factor 1 enhances chemosensitivity to 5-fluorouracil in gastric cancer cellsQ39359345
RhoGDI2 confers gastric cancer cells resistance against cisplatin-induced apoptosis by upregulation of Bcl-2 expressionQ39507361
Prognostic impact of phosphorylated mitogen-activated protein kinase expression in patients with metastatic gastric cancerQ39523783
miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell linesQ39738386
Reversal of P-glycoprotein-mediated multi-drug resistance by the E3 ubiquitin ligase Cbl-b in human gastric adenocarcinoma cellsQ39875032
Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancerQ40063874
Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell deathQ40068228
Reversal of multidrug resistance of gastric cancer cells by downregulation of Akt1 with Akt1 siRNA.Q40169170
Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interferenceQ40514557
Reduced activity of topoisomerase II in an Adriamycin-resistant human stomach-adenocarcinoma cell lineQ41055485
Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatinQ41448414
The association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancerQ41890373
Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cellsQ43049489
Expression of P-glycoprotein and multidrug resistance-associated protein is associated with multidrug resistance in gastric cancerQ43127559
Hypoxia-inducible factor-1alpha expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer.Q43282233
p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax.Q44511919
Expression of thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase, E2F-1, Bak, Bcl-X, and Bcl-2, and clinical outcomes for gastric cancer patients treated with bolus 5-fluorouracilQ44679439
Clinicopathological significance of hypoxia-inducible factor-1 alpha (HIF-1α) expression in gastric cancerQ45798976
Chemosensitivity patterns and expression of human multidrug resistance-associated MDR1 gene by human gastric and colorectal carcinoma cell lines.Q45940694
TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activationQ46890868
Up-regulation of survivin by AKT and hypoxia-inducible factor 1α contributes to cisplatin resistance in gastric cancer.Q51774995
Activated Akt as an indicator of prognosis in gastric cancer.Q53448904
Bax predicts outcome in gastric cancer patients treated with 5-fluorouracil, leucovorin, and oxaliplatin palliative chemotherapy.Q53469725
The role of P-glycoprotein in human gastric cancer xenografts in response to chemotherapy.Q53981103
High expression of multidrug resistance-1 (MDR-1) and its relationship with multiple prognostic factors in gastric carcinomas in patients in Turkey.Q54082473
Expression of P-glycoprotein influences resistance against anthracyclines in clinical gastric carcinomas.Q54213578
Expression of glutathione-S-transferases alpha and pi in gastric cancer: a correlation with cisplatin resistance.Q54220328
MDR1 gene expression and its clinical relevance in primary gastric carcinomas.Q54248632
Expression of a multidrug resistance gene in esophageal adenocarcinoma. Correlation with response to chemotherapy and comparison with gastric adenocarcinoma.Q54338124
Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis.Q54513779
HER-2/neu and TOPIIa expression in gastric cancer reflect disease severity.Q54533786
The prevalence of PIK3CA mutations in gastric and colon cancer.Q54655912
Expression of glutathione S-transferases in normal gastric mucosa and in gastric tumorsQ68920954
P-glycoprotein as an intermediate end point of drug resistance to neoadjuvant chemotherapy in locally advanced gastric cancerQ73106648
Expression and relationship between topoisomerase I and II alpha genes in tumor and normal tissues in esophageal, gastric and colon cancersQ73499360
Bax overexpression enhances cytochrome c release from mitochondria and sensitizes KATOIII gastric cancer cells to chemotherapeutic agent-induced apoptosisQ73548876
Glutathione S-transferases and iododeoxyuridine labelling index during chemotherapy of gastric cancerQ74118428
Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapyQ79863813
Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and BaxQ80856775
Relationship between expression of apoptosis-related proteins and the efficacy of postoperative chemotherapy in patients with T3 gastric cancerQ82815102
Tissue microarray analysis of topoisomerase IIalpha protein in gastric adenocarcinomas: histogenetic and prognostic implicationsQ83963207
Tumor chemosensitivity is correlated with expression of multidrug resistance associated factors in variously differentiated gastric carcinoma tissuesQ84928233
Association between ABCB1 immunohistochemical expression and overall survival in gastric cancer patientsQ85210565
Signature of cytokines and angiogenic factors (CAFs) defines a clinically distinct subgroup of gastric cancerQ86934356
The relationships between the chemosensitivity of human gastric cancer to paclitaxel and the expressions of class III β-tubulin, MAPT, and survivinQ87659652
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)673-81
P577publication date2016-09-15
P1433published inWorld journal of gastrointestinal oncologyQ27723329
P1476titleMolecular mechanisms of chemoresistance in gastric cancer
P478volume8

Reverse relations

cites work (P2860)
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