Benzyl Isothiocyanate Induces Apoptosis via Reactive Oxygen Species-Initiated Mitochondrial Dysfunction and DR4 and DR5 Death Receptor Activation in Gastric Adenocarcinoma Cells

scientific article published on 06 December 2019

Benzyl Isothiocyanate Induces Apoptosis via Reactive Oxygen Species-Initiated Mitochondrial Dysfunction and DR4 and DR5 Death Receptor Activation in Gastric Adenocarcinoma Cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/BIOM9120839
P932PMC publication ID6995572
P698PubMed publication ID31817791

P50authorUy Dong SohnQ85666401
P2093author name stringHyun-Jung Kim
Khin Wah Wah Han
Wah Wah Po
P2860cites workROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells.Q52338960
Discovery of a Small Molecule that Enhances Astrocytogenesis by Activation of STAT3, SMAD1/5/8, and ERK1/2 via Induction of Cytokines in Neural Stem Cells.Q52906673
Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cellsQ58709077
The Glu228Ala polymorphism in the ligand binding domain of death receptor 4 is associated with increased risk for prostate cancer metastasesQ80419514
Synergistic apoptosis of human gastric cancer cells by bortezomib and TRAILQ91046297
The role of XIAP in resistance to TNF-related apoptosis-inducing ligand (TRAIL) in LeukemiaQ91771142
Adapting and Surviving: Intra and Extra-Cellular Remodeling in Drug-Resistant Gastric Cancer CellsQ92343509
Epidemiology of gastric cancer: global trends, risk factors and preventionQ92832146
Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat DietQ93036212
Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanateQ38760083
Oral administration of benzyl-isothiocyanate inhibits in vivo growth of subcutaneous xenograft tumors of human malignant melanoma A375.S2 cellsQ39103199
Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling.Q39332546
Changes in the Leading Cause of Death: Recent Patterns in Heart Disease and Cancer MortalityQ39419312
Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathwaysQ39700912
Fluoxetine induces apoptosis in ovarian carcinoma cell line OVCAR-3 through reactive oxygen species-dependent activation of nuclear factor-kappaB.Q39755823
Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skinQ39798577
Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines.Q39875342
Role of caspases in cleavage of lamin A/C and PARP during apoptosis in macrophages infected with a periodontopathic bacteriumQ40076669
Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small cell lung cancer cells: a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation.Q40172696
Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak.Q40205220
Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells.Q40386560
Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosisQ40761750
Cell death: TRAIL and its receptorsQ41651163
Benzyl isothiocyanate induces reactive oxygen species-initiated autophagy and apoptosis in human prostate cancer cellsQ42292338
Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3.Q43209013
Benzyl isothiocyanate is the chief or sole anthelmintic in papaya seed extractsQ43630672
Protective effect of reduced glutathione against cisplatin-induced renal and systemic toxicity and its influence on the therapeutic activity of the antitumor drugQ45895833
Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic CancerQ46456077
Benzyl isothiocyanate promotes apoptosis of oral cancer cells via an acute redox stress-mediated DNA damage responseQ46469222
Apoptosis: A Target for Anticancer TherapyQ47549627
Apoptosis signaling by death receptors.Q47751546
Treatment of gastric cancerQ24602875
Nutrition and cancer: a review of the evidence for an anti-cancer dietQ24792822
Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategiesQ26750639
Molecular mechanisms of chemoresistance in gastric cancerQ28069259
Molecular targeted therapy for the treatment of gastric cancerQ28072433
Cancer chemoprevention with dietary isothiocyanates mature for clinical translational researchQ28269727
Molecular targets of isothiocyanates in cancer: recent advancesQ28307527
Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathioneQ28365472
Evaluation of Direct Colorimetric MTT Assay for Rapid Detection of Rifampicin and Isoniazid Resistance in Mycobacterium tuberculosisQ28468518
Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic deathQ28581047
Phenethyl isothiocyanate sensitizes glioma cells to TRAIL-induced apoptosisQ30457366
Andrographolide induces apoptotic and non-apoptotic death and enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in gastric cancer cellsQ33685962
Morphologic and biochemical hallmarks of apoptosisQ33869981
Proteases for cell suicide: functions and regulation of caspasesQ33927179
Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathwaysQ34093379
Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells.Q34106016
Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cellsQ34158284
The changing faces of glutathione, a cellular protagonistQ34269360
Chestnut extract induces apoptosis in AGS human gastric cancer cellsQ35097709
Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathwaysQ35103563
Global burden of cancer.Q36014891
Overview of cell death signaling pathwaysQ36051647
Protective effect of reduced glutathione C60 derivative against hydrogen peroxide-induced apoptosis in HEK 293T cellsQ36067528
Poncirin Induces Apoptosis in AGS Human Gastric Cancer Cells through Extrinsic Apoptotic Pathway by up-Regulation of Fas LigandQ36184282
Tumor priming by Apo2L/TRAIL reduces interstitial fluid pressure and enhances efficacy of liposomal gemcitabine in a patient derived xenograft tumor modelQ36218165
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosisQ36364894
Bioactive food components and cancer risk reductionQ37037533
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, ChinaQ37376279
2',7'-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversyQ37724866
Natural isothiocyanates: genotoxic potential versus chemopreventionQ37969540
Cell Death SignalingQ38655649
Benzyl isothiocyanate (BITC) induces apoptosis of GBM 8401 human brain glioblastoma multiforms cells via activation of caspase-8/Bid and the reactive oxygen species-dependent mitochondrial pathwayQ38694458
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P921main subjectreactive oxygen speciesQ424361
gastric adenocarcinomaQ18556047
P577publication date2019-12-06
P1433published inBiomoleculesQ23929963
P1476titleBenzyl Isothiocyanate Induces Apoptosis via Reactive Oxygen Species-Initiated Mitochondrial Dysfunction and DR4 and DR5 Death Receptor Activation in Gastric Adenocarcinoma Cells
P478volume9