Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death

scientific journal article

Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M002361200
P698PubMed publication ID10980192

P50authorAmalia AzzaritiQ57163329
Anna AtlanteQ42851246
P2093author name stringP. Calissano
S. Passarella
E. Marra
A. Bobba
P2860cites workDisruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition.Q52530792
Superoxide dismutase: a comparison of rate constants.Q53745613
Release of cytochrome c from liver mitochondria during permeability transition.Q53971897
Glycine potentiates the NMDA response in cultured mouse brain neuronsQ59050531
Detection of reactive oxygen species in primary cultures of cerebellar granule cellsQ60662691
Development of a method for measuring cell number: Application to CNS primary neuronal culturesQ60977085
The antioxidant functions of cytochrome cQ73224045
Simultaneous release of adenylate kinase and cytochrome c in cell deathQ77812590
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDACQ22009974
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Identification of a mitochondrial Na+/H+ exchangerQ24318319
Bax directly induces release of cytochrome c from isolated mitochondriaQ28588847
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosisQ29616513
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.Q33887952
Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial functionQ34296896
Glutamate neurotoxicity and diseases of the nervous systemQ34560997
8 Preparation and properties of complex IV (Ferrocytochrome c: Oxygen oxidoreductase EC 1.9.3.1)Q40185506
Oxidative stress, glutamate, and neurodegenerative disordersQ40618533
Glutamate stimulates 2-deoxyglucose uptake in rat cerebellar granule cells.Q42447043
Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell culturesQ42447104
Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slicesQ46598715
Early release and subsequent caspase-mediated degradation of cytochrome c in apoptotic cerebellar granule cellsQ48112961
Glutamate neurotoxicity in rat cerebellar granule cells involves cytochrome c release from mitochondria and mitochondrial shuttle impairmentQ48175028
NMDA-dependent superoxide production and neurotoxicityQ48234286
Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cellsQ48248439
Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivoQ48301544
Mitochondria and neuronal glutamate excitotoxicityQ48406562
A rapid method for the isolation of metabolically active mitochondria from rat neurons and astrocytes in primary cultureQ48477465
Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons.Q48610377
P433issue47
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
cerebellumQ130983
excitotoxicityQ901117
reactive oxygen speciesQ424361
P304page(s)37159–37166
P577publication date2000-11-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleCytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death
P478volume275

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cites work (P2860)
Q468858414-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG.
Q48290147Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting
Q34127614Alzheimer's proteins, oxidative stress, and mitochondrial dysfunction interplay in a neuronal model of Alzheimer's disease
Q39847273An agonistic monoclonal antibody against DR5 induces ROS production, sustained JNK activation and Endo G release in Jurkat leukemia cells
Q34713989Analysis of mitochondrial ND1 gene in human colorectal cancer
Q44123337Analysis of mitochondrial free radical generation in animal models of neuronal disease
Q33739831Antiproliferative and apoptotic effects of Sesbania grandiflora leaves in human cancer cells
Q38695535Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway.
Q38880248As2O3 induces apoptosis in human hepatocellular carcinoma HepG2 cells through a ROS-mediated mitochondrial pathway and activation of caspases
Q91815478Benzyl Isothiocyanate Induces Apoptosis via Reactive Oxygen Species-Initiated Mitochondrial Dysfunction and DR4 and DR5 Death Receptor Activation in Gastric Adenocarcinoma Cells
Q38349383Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria
Q44156181Caspase activation in hair cells of the mouse utricle exposed to neomycin.
Q48588017Caspase-dependent alteration of the ADP/ATP translocator triggers the mitochondrial permeability transition which is not required for the low-potassium-dependent apoptosis of cerebellar granule cells
Q53842733Cellular prion protein contributes to LS 174T colon cancer cell carcinogenesis by increasing invasiveness and resistance against doxorubicin-induced apoptosis.
Q74613490Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells
Q35047462Cobalt protoporphyrin induces HO-1 expression mediated partially by FOXO1 and reduces mitochondria-derived reactive oxygen species production
Q42123867Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.
Q37176533Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells
Q39876387Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death
Q45271555Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae
Q46658299Cytochrome c is released from coupled mitochondria of yeast en route to acetic acid-induced programmed cell death and can work as an electron donor and a ROS scavenger
Q46986683Cytochrome c is released in a reactive oxygen species-dependent manner and is degraded via caspase-like proteases in tobacco Bright-Yellow 2 cells en route to heat shock-induced cell death
Q46744858DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures
Q88767698Developmental and molecular responses of buffalo (Bubalus bubalis) cumulus-oocyte complex matured in vitro under heat shock conditions
Q38878261Differential sensitivity of coral larvae to natural levels of ultraviolet radiation during the onset of larval competence
Q39398672Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies.
Q40811069Elevated superoxide production by active H-ras enhances human lung WI-38VA-13 cell proliferation, migration and resistance to TNF-alpha
Q41912110Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism
Q46525122Excitotoxic injury to mitochondria isolated from cultured neurons.
Q91762120FAD/NADH Dependent Oxidoreductases: From Different Amino Acid Sequences to Similar Protein Shapes for Playing an Ancient Function
Q34979701Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release.
Q34263800Glutamate neurotoxicity, oxidative stress and mitochondria.
Q28575769Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens
Q24806246Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release
Q34063254Immunocytochemical studies on the effect of 405-nm low-power laser irradiation on human-derived A-172 glioblastoma cells
Q28581118Increased Rat Brain Cytochrome C Correlates with Degree of Perinatal Copper Deficiency Rather than Apoptosis
Q44086485Inhibition of oxidative stress produced by plasma membrane NADH oxidase delays low-potassium-induced apoptosis of cerebellar granule cells
Q44068268Inhibition of phosphate transport in rat heart mitochondria by 3'-azido-3'-deoxythymidine due to stimulation of superoxide anion mitochondrial production
Q34441654Interaction of TNF with angiotensin II contributes to mitochondrial oxidative stress and cardiac damage in rats
Q42620778Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease
Q40469936Malonate induces cell death via mitochondrial potential collapse and delayed swelling through an ROS-dependent pathway.
Q39741096Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries
Q99202584Membrane-tethering of cytochrome c accelerates regulated cell death in yeast
Q34162244Mitochondria-targeted antioxidant prevents cardiac dysfunction induced by tafazzin gene knockdown in cardiac myocytes
Q35597927Mitochondrial control of neuron death and its role in neurodegenerative disorders.
Q35564763Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases
Q38023284Mitochondrial network in the heart
Q33217405Mitochondrion-targeted photosensitizer enhances the photodynamic effect-induced mitochondrial dysfunction and apoptosis
Q33210189Mutations of mitochondrial 12S rRNA in gastric carcinoma and their significance
Q34500860Neuronal injury in bacterial meningitis: mechanisms and implications for therapy
Q46477094Nonylphenol diethoxylate inhibits apoptosis induced in PC12 cells
Q44764287Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I.
Q37711952Ophiobolin A, a sesterpenoid fungal phytotoxin, displays different mechanisms of cell death in mammalian cells depending upon the cancer cell origin
Q43960634P2 receptor modulation and cytotoxic function in cultured CNS neurons
Q46619662Peroxynitrite is Involved in the Apoptotic Death of Cultured Cerebellar Granule Neurons Induced by Staurosporine, but not by Potassium Deprivation
Q43953859Proteasome inhibitors prevent cytochrome c release during apoptosis but not in excitotoxic death of cerebellar granule neurons
Q33494069Protective effects of the free radical scavenger edaravone against glutamate neurotoxicity in nearly pure neuronal culture
Q33210190Quantitative analysis of tumor mitochondrial RNA using microarray
Q86428901Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug-DNA interaction
Q34761154Radiation-induced intercellular signaling mediated by cytochrome-c via a p53-dependent pathway in hepatoma cells
Q44163178Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax.
Q51731765Relating the multi-functionality of cytochrome c to membrane binding and structural conversion.
Q48254989Selective cytochrome c displacement by phosphate and Ca(2+) in brain mitochondria.
Q36542999Single-walled carbon nanotubes alter cytochrome c electron transfer and modulate mitochondrial function
Q38040407Targeting malignant mitochondria with therapeutic peptides.
Q44086462The NADH oxidase activity of the plasma membrane of synaptosomes is a major source of superoxide anion and is inhibited by peroxynitrite
Q64096078The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation
Q83117335The effect of iron overload and chelation on erythroid differentiation
Q41835286The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response
Q44516512The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells
Q35848514The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism
Q43071368Ulinastatin inhibits oxidant-induced endothelial hyperpermeability and apoptotic signaling
Q36309165Variations of mitochondrial D-loop region plus downstream gene 1 2S rRNA-tRNA(phe) and gastric carcinomas
Q43249349Verteporfin-photoinduced apoptosis in HepG2 cells mediated by reactive oxygen and nitrogen species intermediates
Q94594539Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin
Q43234994Yeast acetic acid-induced programmed cell death can occur without cytochrome c release which requires metacaspase YCA1.