Ageing, neurodegeneration and brain rejuvenation

scientific article published on 10 November 2016

Ageing, neurodegeneration and brain rejuvenation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1047984892
P356DOI10.1038/NATURE20411
P932PMC publication ID5172605
P698PubMed publication ID27830812

P50authorTony Wyss-CorayQ23782672
P2860cites workExtensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.Q53369656
The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900Q56851491
DNA methylation age of human tissues and cell typesQ21183994
TREM2 Variants in Alzheimer's DiseaseQ22250873
Variant of TREM2 Associated with the Risk of Alzheimer's DiseaseQ22250874
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's diseaseQ22251067
The ageing systemic milieu negatively regulates neurogenesis and cognitive function.Q24599219
Meta‐analysis of genetic variants associated with human exceptional longevityQ24605503
Distinct DNA methylation changes highly correlated with chronological age in the human brainQ24616264
Protective effects of NSAIDs on the development of Alzheimer diseaseQ24656148
Suspected non-Alzheimer disease pathophysiology--concept and controversyQ26771270
Blood-Borne Revitalization of the Aged BrainQ26799718
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesisQ27315300
The hallmarks of agingQ28131641
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscleQ28239514
Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factorsQ28239524
Neuroinflammation in Alzheimer's diseaseQ28259238
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophyQ28290417
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in miceQ28591283
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteinsQ44917427
Age-related myelin degradation burdens the clearance function of microglia during aging.Q46707647
Effect of exercise training on plasma visfatin and eotaxin levelsQ46983590
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology.Q50646784
Genetic influence on human lifespan and longevity.Q51820158
Anti-inflammatory drugs and Alzheimer disease.Q53183421
Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease.Q53328363
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortiumQ28596242
Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease neuroimaging initiative (ADNI) plasma proteome datasetQ28730795
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's diseaseQ28943325
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's diseaseQ29614879
Rejuvenation of aged progenitor cells by exposure to a young systemic environmentQ29615250
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressorQ29615559
mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.Q30539812
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRHQ30543829
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.Q30597164
Preclinical Assessment of Young Blood Plasma for Alzheimer Disease.Q30832612
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.Q31063014
Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus.Q32062012
Systemic inflammation and disease progression in Alzheimer diseaseQ33765718
The epigenetic landscape of Alzheimer's disease.Q33802600
Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevityQ33811539
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseasesQ34040980
The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a reviewQ34074186
Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal agingQ34117787
A pathophysiological framework of hippocampal dysfunction in ageing and diseaseQ34214060
Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathiesQ34281671
The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900.Q34395093
Plasma based markers of [11C] PiB-PET brain amyloid burdenQ34427001
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other lociQ34433829
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's diseaseQ34433837
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's diseaseQ34463543
Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patientsQ34504712
Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future InvestigationQ34520504
Deep biomarkers of human aging: Application of deep neural networks to biomarker developmentQ34527074
Plasma proteins predict conversion to dementia from prodromal diseaseQ34556953
The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosisQ34621569
A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in MicrogliaQ34672284
Non-steroidal anti-inflammatory drug use and the risk of Parkinson's diseaseQ34985170
Proinflammatory cytokines, sickness behavior, and Alzheimer diseaseQ35104455
Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome.Q35497573
Circulating Proteomic Signatures of Chronological Age.Q35746977
Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-cateninQ35775341
Young, proliferative thymic epithelial cells engraft and function in aging thymusesQ35783525
Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer arrayQ35951935
Multiple pathologies are common and related to dementia in the oldest-old: The 90+ StudyQ35966448
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer diseaseQ36183810
Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive agingQ36197707
The epidemiology of longevity and exceptional survivalQ36449872
Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease.Q36594535
CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain agingQ36598397
Novel loci and pathways significantly associated with longevityQ36615898
Altered Proteins in the Aging BrainQ36692073
Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI.Q36796489
Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participantsQ36802036
Network-driven plasma proteomics expose molecular changes in the Alzheimer's brainQ36836566
Whole-Genome Sequencing of a Healthy Aging CohortQ36880280
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's diseaseQ36914722
Plasma biomarkers associated with the apolipoprotein E genotype and Alzheimer diseaseQ36932748
Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease.Q37020043
Rejuvenation of regeneration in the aging central nervous systemQ37023170
Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trialQ37151258
Immune activation in brain aging and neurodegeneration: too much or too little?Q37617634
Microglial dysfunction in brain aging and Alzheimer's diseaseQ37678533
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotypeQ37886047
Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx.Q38012092
Immunotherapy for Alzheimer's disease: past, present and futureQ38222750
Genetic factors associated with longevity: a review of recent findingsQ38275055
Compromised autophagy and neurodegenerative diseasesQ38492623
Microglial brain region-dependent diversity and selective regional sensitivities to aging.Q38642851
Aging-associated changes in human brainQ41669704
Systemic regulation of the age-related decline of pancreatic β-cell replicationQ41842271
MHC class I: an unexpected role in neuronal plasticityQ42115670
Enhancement of memories by systemic administration of insulin-like growth factor II.Q42740389
Eotaxin and obesityQ42808492
Pathological stress granules in Alzheimer's diseaseQ43056232
One year of insulin-like growth factor I treatment does not affect bone density, body composition, or psychological measures in postmenopausal womenQ43571560
Aβ secretion and plaque formation depend on autophagyQ44061458
P433issue7628
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
neurodegenerationQ1755122
P304page(s)180-186
P577publication date2016-11-10
P1433published inNatureQ180445
P1476titleAgeing, neurodegeneration and brain rejuvenation
P478volume539

Reverse relations

cites work (P2860)
Q47872845"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities".
Q52431215A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease.
Q57188247A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
Q90561593A hormone receptor pathway cell-autonomously delays neuron morphological aging by suppressing endocytosis
Q49578602A transcriptomic atlas of aged human microglia.
Q62748361Absolute quantitative lipidomics reveals lipidome-wide alterations in aging brain
Q59126043Advanced model systems and tools for basic and translational human immunology
Q92381661Age- and disease-specific changes of the kynurenine pathway in Parkinson's and Alzheimer's disease
Q92523995Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response
Q92001084Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
Q90003697Ageing as a risk factor for neurodegenerative disease
Q49372792Aging and the Krüppel-like factors.
Q60923331Bioassay for monitoring the anti-aging effect of cord blood treatment
Q46250174Black Phosphorus Nanosheets as a Neuroprotective Nanomedicine for Neurodegenerative Disorder Therapy.
Q98725888Blood substitution therapy rescues the brain of mice from ischemic damage
Q90745439Boosting Antioxidant Self-defenses by Grafting Astrocytes Rejuvenates the Aged Microenvironment and Mitigates Nigrostriatal Toxicity in Parkinsonian Brain via an Nrf2-Driven Wnt/β-Catenin Prosurvival Axis
Q54953232Brain Mitochondria, Aging, and Parkinson's Disease.
Q42364364CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease.
Q88308572Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation
Q52586031Can Curcumin Counteract Cognitive Decline? Clinical Trial Evidence and Rationale for Combining ω-3 Fatty Acids with Curcumin.
Q38643560Cardiovascular Disease, the Nitric Oxide Pathway and Risk of Cognitive Impairment and Dementia
Q92513138Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer's Disease
Q96816564Cellular senescence and Alzheimer disease: the egg and the chicken scenario
Q54217784Chemical compound-based direct reprogramming for future clinical applications.
Q57050335Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus
Q90331275Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood
Q47119516Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins.
Q92259337Combining Chalcones with Donepezil to Inhibit Both Cholinesterases and Aβ Fibril Assembly
Q41573979Comparative Studies on Behavioral, Cognitive and Biomolecular Profiling of ICR, C57BL/6 and Its Sub-Strains Suitable for Scopolamine-Induced Amnesic Models.
Q64119240Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTPβ/ζ Axis: Relevance in Therapeutic Development
Q54205666Connections of annexin A1 and translocator protein-18 kDa on toll like receptor stimulated BV-2 cells.
Q102220208Decoding individual identity from brain activity elicited in imagining common experiences
Q55715569Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy.
Q64111365Deficits in Social Behavior Precede Cognitive Decline in Middle-Aged Mice
Q64117846Designing and Characterization of a Novel Delivery System for Improved Cellular Uptake by Brain Using Dendronised Apo-E-Derived Peptide
Q61798592Dose-response relationship between exercise and cognitive function in older adults with and without cognitive impairment: A systematic review and meta-analysis
Q96110145Effect of a multicomponent exercise intervention on brain metabolism: A randomized controlled trial on Alzheimer's pathology (Dementia-MOVE)
Q64237552Effects of Thioflavin T and GSK-3 Inhibition on Lifespan and Motility in a Model of Tauopathy
Q58799729Estimation of the cancer risk induced by therapies targeting stem cell replication and treatment recommendations
Q63245460Evaluation of the Antioxidant and Neuroprotectant Activities of New Asymmetrical 1,3-Diketones
Q48043354Exceptional in vivo catabolism of neurodegeneration-related aggregates
Q89701192FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
Q50115461Framework for Considering Productive Aging at Work.
Q97882884GABAergic Inhibitory Interneuron Deficits in Alzheimer's Disease: Implications for Treatment
Q58700782Gene Expression Analysis Reveals Novel Gene Signatures Between Young and Old Adults in Human Prefrontal Cortex
Q90220217Genome editing methods in animal models
Q95840660Genome-Wide Screen of the Hippocampus in Aged Rats Identifies Mitochondria, Metabolism and Aging Processes Implicated in Sevoflurane Anesthesia
Q90736866Ginkgo biloba Prevents Oxidative Stress-Induced Apoptosis Blocking p53 Activation in Neuroblastoma Cells
Q98577050Ginseng gintonin, aging societies, and geriatric brain diseases
Q38600419Gray matter structural networks are associated with cardiovascular risk factors in healthy older adults
Q59333076Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice
Q58765738Horizons in the evolution of aging
Q64287877Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5
Q64261557Hyperoxygenation revitalizes Alzheimer's disease pathology through the upregulation of neurotrophic factors
Q91646668Hypoxia-Induced Degenerative Protein Modifications Associated with Aging and Age-Associated Disorders
Q47382007Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration
Q90369806Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice
Q92994454Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence
Q41140219Interplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-β (Aβ) Toxicity in Yeast
Q64888123Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling.
Q59812412Is Alzheimer's Also a Stem Cell Disease? - The Zebrafish Perspective
Q49545472Kynurenic acid accumulation underlies learning and memory impairment associated with aging.
Q57799708Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations
Q54455762Long Non-Coding RNAs in Neuronal Aging.
Q43375858Markers of Alzheimer's Disease in Primary Visual Cortex in Normal Aging in Mice
Q61816980Material and Structural Modeling Aspects of Brain Tissue Deformation under Dynamic Loads
Q64119705Matter over mind: Liquid phase separation and neurodegeneration
Q55496634Metabolic enzymes in glial cells of the honeybee brain and their associations with aging, starvation and food response.
Q90579247Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer's Disease
Q88920896Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile
Q47123936Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease.
Q91667311Monitoring metal-amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening
Q47251476Multi-Protection of DL0410 in Ameliorating Cognitive Defects in D-Galactose Induced Aging Mice
Q88725530Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
Q57288794Multiplication of the SNCA locus exacerbates neuronal nuclear aging
Q64120496Neural Plasticity during Aging
Q39335873Neural Stem Cell Plasticity: Advantages in Therapy for the Injured Central Nervous System
Q42344614Neurodegenerative disease: models, mechanisms, and a new hope.
Q64073405Neuroinflammation and Perioperative Neurocognitive Disorders
Q64100444Neuroprotective Effect of Dioscin on the Aging Brain
Q92770486New terminology for a common TDP-43 proteinopathy
Q90754400Normal tension glaucoma-like degeneration of the visual system in aged marmosets
Q94450771Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study
Q53397884Odor Enrichment Increases Hippocampal Neuron Numbers in Mouse.
Q33624540Old Maids: Aging and Its Impact on Microglia Function
Q98563342Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders
Q93138367Peptide-conjugate antisense based splice-correction for Duchenne muscular dystrophy and other neuromuscular diseases
Q57039635Peripheral immune system in aging and Alzheimer's disease
Q90644110Perspective: Is therapeutic plasma exchange a viable option for treating Alzheimer's disease?
Q89683184Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases
Q41585770Prescription database analyses indicates that the asthma medicine montelukast might protect against dementia: a hypothesis to be verified
Q92596330Protective Effects of Hydrolyzed Chicken Extract (Probeptigen®/Cmi-168) on Memory Retention and Brain Oxidative Stress in Senescence-Accelerated Mice
Q92416204Protein-based amide proton transfer-weighted MR imaging of amnestic mild cognitive impairment
Q48143800Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression
Q46092009RNA targeting with CRISPR-Cas13.
Q60950137Repairing the Brain: Gene Therapy
Q30234641Role of circulating factors in cardiac aging.
Q90263029Single-cell transcriptomic profiling of the aging mouse brain
Q96302713Spatially-resolved metabolic profiling of living Drosophila in neurodegenerative conditions using 1H magic angle spinning NMR
Q92501090Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment
Q57157667Stem cell therapy for neurological disorders: A focus on aging
Q47717967Stem cells: Aging and transcriptional fingerprints
Q38373457Subclinical Atherosclerosis, Cardiac and Kidney Function, Heart Failure, and Dementia in the Very Elderly
Q90296581Targeting Iron Dyshomeostasis for Treatment of Neurodegenerative Disorders
Q51758684The Aging of Iron Man.
Q92354128The cGAS/STING pathway: a sensor of senescence-associated DNA damage and trigger of inflammation in early age-related macular degeneration
Q48221587The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain.
Q95936711The quest to slow ageing through drug discovery
Q46268121The role of mitochondrial ROS in the aging brain
Q41208095Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease.
Q89036250Tissue-Specific Upregulation of Drosophila Insulin Receptor (InR) Mitigates Poly(Q)-Mediated Neurotoxicity by Restoration of Cellular Transcription Machinery
Q92522957Transcriptome analysis of the hippocampus in environmental noise-exposed SAMP8 mice reveals regulatory pathways associated with Alzheimer's disease neuropathology
Q91559758Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Q92635625Uncovering the Pharmacological Mechanism of Stemazole in the Treatment of Neurodegenerative Diseases Based on a Network Pharmacology Approach
Q92796940Use of large animal models to investigate Huntington's diseases
Q90698963VEGF receptor-1 modulates amyloid β 1-42 oligomer-induced senescence in brain endothelial cells
Q64069093Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints
Q46252338Vertebrate food products as a potential source of prion-like α-synuclein.
Q58602514Young and aged TLR4 deficient mice show sex-dependent enhancements in spatial memory and alterations in interleukin-1 related genes
Q53397794Young blood products: emerging treatment for Alzheimer's disease?
Q64262792Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage

Search more.