Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function

scientific article

Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FPHYS.2016.00573
P932PMC publication ID5124694
P698PubMed publication ID27965583

P2093author name stringFrancisco J. Barrantes
Silvia S. Antollini
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External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acidsQ24564480
Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilonQ24633521
Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1Q28212731
Protein kinase C and lipid signaling for sustained cellular responsesQ28300819
Polyunsaturated fatty acids are potent neuroprotectorsQ28344163
Linolenic acid provides multi-cellular protective effects after photothrombotic cerebral ischemia in ratsQ28575123
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic HomeostasisQ29032115
Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel functionQ30416781
Gating of acetylcholine receptor channels: brownian motion across a broad transition stateQ30856044
The crucial role of plant mitochondria in orchestrating drought toleranceQ31159109
Steroids differentially inhibit the nicotinic acetylcholine receptorQ32037160
Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel.Q33421003
Electrostatic tuning of cellular excitabilityQ33622097
Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytesQ33749115
ATP-sensitive K+ channels in insulinoma cells are activated by nonesterified fatty acidsQ68118366
Regulation of K+ channels in cardiac myocytes by free fatty acidsQ68357977
Phosphorylation of membrane-bound acetylcholine receptor by protein kinase C: characterization and subunit specificityQ68913490
Lipid-protein interactions in reconstituted membranes containing acetylcholine receptorQ70178822
Functional properties of the acetylcholine receptor incorporated in model lipid membranes. Differential effects of chain length and head group of phospholipids on receptor affinity states and receptor-mediated ion translocationQ71430998
Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acidQ71822832
Modulatory action of arachidonic acid on GABAA/chloride channel receptor function in adult and aged brain cortex membranesQ72556001
Interactions of the nicotinic acetylcholine receptor transmembrane segments with the lipid bilayer in native receptor-rich membranesQ73040675
Effect of membrane lipid composition on the conformational equilibria of the nicotinic acetylcholine receptorQ73334305
Arachidonic acid and prostaglandin D2 cooperatively accelerate desensitization of nicotinic acetylcholine receptor channel in mouse skeletal musclesQ73416494
Fatty acid-activated K+ channels in autonomic neurons: activation by an endogenous source of free fatty acidsQ73491118
Arachidonic acid metabolic pathways regulating activity of renal Na(+)-K(+)-ATPase are age dependentQ73782714
Inhibitory effects of arachidonic acid on nicotinic transmission in bullfrog sympathetic neuronsQ73843117
Topography of nicotinic acetylcholine receptor membrane-embedded domainsQ74248176
Disclosure of discrete sites for phospholipid and sterols at the protein-lipid interface in native acetylcholine receptor-rich membraneQ77648565
Conformation-sensitive steroid and fatty acid sites in the transmembrane domain of the nicotinic acetylcholine receptorQ79824869
Structural basis for lipid modulation of nicotinic acetylcholine receptor functionQ81078595
Arachidonic acid inhibits Na⁺-K⁺-ATPase via cytochrome P-450, lipoxygenase and protein kinase C-dependent pathways in sheep pulmonary arteryQ82878409
The position of the double bond in monounsaturated free fatty acids is essential for the inhibition of the nicotinic acetylcholine receptorQ84378475
Arachidonic acid stimulates DNA synthesis in brown preadipocytes through the activation of protein kinase C and MAPKQ84528963
Activation of the plant mitochondrial potassium channel by free fatty acids and acyl-CoA esters: a possible defence mechanism in the response to hyperosmotic stressQ84964271
Polyunsaturated fatty acids induce ischemic and epileptic tolerance.Q43860471
The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent mannerQ43999135
Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of actionQ44174289
Phospholipase A2 hydrolysis of membrane phospholipids causes structural alteration of the nicotinic acetylcholine receptorQ44287237
The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptorsQ44366548
Three distinct forms of rat brain protein kinase C: differential response to unsaturated fatty acidsQ44382132
Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organQ44528795
Long-chain CoA esters activate human pancreatic beta-cell KATP channels: potential role in Type 2 diabetesQ44739809
Mutations in the M4 Domain of the Torpedo californica Nicotinic Acetylcholine Receptor Alter Channel Opening and ClosingQ44931151
The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminalsQ45160936
Conformational dynamics of the nicotinic acetylcholine receptor channel: a 35-ns molecular dynamics simulation studyQ45237730
Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responsesQ45264455
Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid.Q45940143
Tryptophan substitutions at the lipid-exposed transmembrane segment M4 of Torpedo californica acetylcholine receptor govern channel gating.Q46028727
Arachidonic acid as a possible negative feedback inhibitor of nicotinic acetylcholine receptors on neurons.Q46044571
Vasoregulation by the beta1 subunit of the calcium-activated potassium channelQ46410172
Modulation of nicotinic acetylcholine receptor conformational state by free fatty acids and steroidsQ46568369
{Omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channelsQ46575091
Lipid modulation of nicotinic acetylcholine receptor function: the role of membrane lipid composition and fluidityQ46622440
Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acidQ46836414
Modulation of ACh receptor currents by arachidonic acidQ47962426
Regulation of gamma-aminobutyric acid/barbiturate receptor-gated chloride ion flux in brain vesicles by phospholipase A2: possible role of oxygen radicalsQ48121494
Characterization of the influence of unsaturated free fatty acids on brain GABA/benzodiazepine receptor binding in vitro.Q48145474
The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions.Q48146067
Arachidonic acid induces a long-lasting facilitation of hippocampal synaptic transmission by modulating PKC activity and nicotinic ACh receptorsQ48188036
Free fatty acid derivative HUHS2002 potentiates α7 ACh receptor responses through indirect activation of CaMKII.Q48432372
Linoleic acid derivative DCP-LA stimulates vesicular transport of α7 ACh receptors towards surface membraneQ48452191
Biphasic liberation of arachidonic and stearic acids during cerebral ischemiaQ48477243
Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C.Q48581067
Arachidonic acid activation of potassium channels in rat visual cortex neuronsQ48756858
Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acidQ48762213
Oleic acid enhances ACh receptor currents by activation of Ca2+/calmodulin-dependent protein kinase II.Q48962929
Arachidonic acid potentiates ACh receptor currents by protein kinase C activation but not by receptor phosphorylationQ49013549
Inhibition of ion permeability control properties of acetylcholine receptor from Torpedo californica by long-chain fatty acidsQ52499535
Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity.Q53987542
Heterogeneous distribution of acetylcholine receptors in chick myocytes induced by cholesterol enrichment.Q54009704
Hydrocortisone and 11-desoxycortisone modify acetylcholine receptor channel gating.Q54052119
Phospholipase A inhibition of acetylcholine receptor function in Torpedo californica membrane vesiclesQ67051144
Effect of free fatty acids on GABAA receptor ligand bindingQ67492331
Fatty acids inhibit apical membrane chloride channels in airway epitheliaQ33807711
Lipid and mechano-gated 2P domain K(+) channels.Q34083994
Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytesQ34401274
Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channelsQ34756665
Reciprocal regulation of TREK-1 channels by arachidonic acid and CRH in mouse corticotropesQ34788427
Biphasic effect of linoleic acid on connexin 46 hemichannels.Q35026764
Vascular wall: potential target for the physicochemical effects of cis-unsaturated free fatty acidsQ35033839
Regulation of CRIg expression and phagocytosis in human macrophages by arachidonate, dexamethasone, and cytokinesQ35167899
Dual regulation of δ-opioid receptor function by arachidonic acid metabolites in rat peripheral sensory neuronsQ35197875
Modulation of nicotinic acetylcholine receptor function through the outer and middle rings of transmembrane domainsQ35568231
Fatty acid-sensitive two-pore domain K+ channelsQ35599846
Molecular regulations governing TREK and TRAAK channel functions.Q35693711
Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitorQ35830951
TREK-1, a K+ channel involved in neuroprotection and general anesthesiaQ35835856
The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium ChannelQ35890108
How lipids affect the activities of integral membrane proteinsQ35935383
Fatty acids suppress voltage-gated Na+ currents in HEK293t cells transfected with the alpha-subunit of the human cardiac Na+ channelQ35935540
Immobilized lipid in acetylcholine receptor-rich membranes from Torpedo marmorataQ35990601
Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitisQ35992375
Lipid domains in biological membranes: their structural and functional perturbation by free fatty acids and the regulation of receptor mobility. Co-presidential addressQ36093291
Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytesQ36111398
Effects of n-3 Polyunsaturated Fatty Acids on Cardiac Ion ChannelsQ36193646
Direct regulation of ion channels by fatty acidsQ36649339
Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels.Q36712811
Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intakeQ36733984
Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique propertiesQ36821471
Obesity and free fatty acidsQ37001269
A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.Q37268776
20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPaseQ37365057
Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interactionQ37387430
Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implicationsQ37531275
Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteinsQ37661135
Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.Q38107811
Phylogenetic conservation of protein-lipid motifs in pentameric ligand-gated ion channels.Q38403758
Structure of potassium channels.Q38526443
An electrostatic potassium channel opener targeting the final voltage sensor transitionQ39744712
Modulation of muscle rNaV1.4 Na+ channel isoform by arachidonic acid and its non-metabolized analog.Q39903397
Molecular mechanism of arachidonic acid inhibition of the CFTR chloride channelQ40151663
Activation of hEAG1 potassium channels by arachidonic acidQ40205720
Modulation of ion channels by arachidonic acidQ40394692
Role of fatty acids in signal transduction: Modulators and messengersQ40484569
The lipid-activated two-pore domain K+ channel TREK-1 is resistant to hypoxia: implication for ischaemic neuroprotectionQ40501248
Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gatingQ40509023
Protein kinase C: cellular target of the second messenger arachidonic acid?Q40546806
Direct effects of fatty acids and other charged lipids on ion channel activity in smooth muscle cellsQ40546830
Identification of threonine 422 in transmembrane domain alpha M4 of the nicotinic acetylcholine receptor as a possible site of interaction with hydrocortisone.Q40706391
Effects of fatty acids on BK channels in GH(3) cellsQ40852787
Inhibition of cystic fibrosis transmembrane conductance regulator chloride channel currents by arachidonic acidQ40865705
Coexpression with beta(1)-subunit modifies the kinetics and fatty acid block of hH1(alpha) Na(+) channelsQ40868070
PKA and arachidonic acid activation of human recombinant ClC-2 chloride channelsQ40868165
Structural requirements for the interaction of unsaturated free fatty acids with recombinant human GABAA receptor complexesQ40940756
Novel LQT-3 mutation affects Na+ channel activity through interactions between alpha- and beta1-subunitsQ41020380
Modulation of K+ channels by arachidonic acid in T84 cells. I. Inhibition of the Ca(2+)-dependent K+ channel.Q41066502
cis-unsaturated free fatty acids block growth hormone and prolactin secretion in thyrotropin-releasing hormone-stimulated GH3 cells by perturbing the function of plasma membrane integral proteinsQ41143738
Corticosterone modifies the murine muscle acetylcholine receptor channel kinetics.Q41144385
Unsaturated free fatty acids increase benzodiazepine receptor agonist binding depending on the subunit composition of the GABAA receptor complex.Q41156827
Modulation of muscle nicotinic acetylcholine receptors by the glucocorticoid hydrocortisone. Possible allosteric mechanism of channel blockadeQ41157892
Modulation of human muscle sodium channels by intracellular fatty acids is dependent on the channel isoformQ41175857
ATP-sensitive K channel modulation by products of PLA2 action in the insulin-secreting HIT cell lineQ41390722
Effects of phospholipase A2 on the binding and ion permeability control properties of the acetylcholine receptorQ41603091
Desensitization of acetylcholine receptors in BC3H-1 cellsQ41630120
Effects of long-chain fatty acids on the channel activity of the nicotinic acetylcholine receptorQ41662937
Regulation of epidermal-growth-factor-receptor signal transduction by cis-unsaturated fatty acids. Evidence for a protein kinase C-independent mechanismQ41665311
Alteration in ion channel function of mouse nicotinic acetylcholine receptor by mutations in the M4 transmembrane domainQ41682952
Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptorQ41730726
A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cellsQ41757717
Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acidsQ41877460
Functional modulation of human recombinant gamma-aminobutyric acid type A receptor by docosahexaenoic acidQ42060559
Annular and nonannular binding sites for cholesterol associated with the nicotinic acetylcholine receptorQ42214371
Stearic acid facilitates hippocampal neurotransmission by enhancing nicotinic ACh receptor responses via a PKC pathwayQ42452185
Protein kinase C isoforms have differential roles in the regulation of human sebocyte biologyQ42504504
Possible mechanisms underlying the biphasic regulatory effects of arachidonic acid on Ca2+ signaling in HEK293 cellsQ42504600
Inhibition of the Kv4 (Shal) family of transient K+ currents by arachidonic acid.Q42554319
Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: a putative mechanism of antiseizure actionQ42653875
Mutations at lipid-exposed residues of the acetylcholine receptor affect its gating kineticsQ42680595
Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerolQ42793205
GAP43 phosphorylation is critical for growth and branching of retinotectal arbors in zebrafish.Q42952826
Increased expression and altered subcellular distribution of PKC-δ and PKC-ɛ in pulmonary arteries exposed to hypoxia and 15-HETE.Q42975971
Probing the effects of membrane cholesterol in the Torpedo californica acetylcholine receptor and the novel lipid-exposed mutation alpha C418W in Xenopus oocytesQ43744808
Unique effects of different fatty acid species on the physical properties of the torpedo acetylcholine receptor membraneQ43781431
Lipid-protein interactions at the nicotinic acetylcholine receptor. A functional coupling between nicotinic receptors and phosphatidic acid-containing lipid bilayers.Q43781446
P407language of work or nameEnglishQ1860
P921main subjectfatty acidQ61476
P304page(s)573
P577publication date2016-11-28
P1433published inFrontiers in PhysiologyQ2434141
P1476titleFatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function
P478volume7

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cites work (P2860)
Q92402680Alzheimer's Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts
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