Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes

scientific article

Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1995PNAS...9211000X
P356DOI10.1073/PNAS.92.24.11000
P932PMC publication ID40558
P698PubMed publication ID7479925
P5875ResearchGate publication ID15719026

P2093author name stringJ P Morgan
A Leaf
Y F Xiao
J X Kang
P2860cites workImproved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acidsQ24564480
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart diseaseQ34059526
A Classification of Antiarrhythmic Actions Reassessed After a Decade of New DrugsQ34248170
Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytesQ34401274
Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART).Q34464251
Prevention of ischemia-induced ventricular fibrillation by omega 3 fatty acidsQ35233384
Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytesQ35750022
Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytesQ35820391
Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acidsQ36858387
Effect of fatty acids on the ventricular arrhythmia threshold in the isolated heart of the rabbitQ39923518
Upregulation of the rat cardiac sodium channel by in vivo treatment with a class I antiarrhythmic drugQ40341187
Modification of slow inactivation of single sodium channels by phenytoin in neuroblastoma cells.Q41336803
Proton-induced transformation of calcium channel in chick dorsal root ganglion cellsQ42638479
Slow voltage-dependent block of sodium channels in crayfish nerve by dihydropyrazole insecticidesQ43966027
Phosphorylation affects voltage gating of the delayed rectifier K+ channel by electrostatic interactionsQ43969118
Evidence for voltage-dependent block of cardiac sodium channels by tetrodotoxinQ46656741
Influence of dietary lipids on arrhythmias and infarction after coronary artery ligation in rats.Q51819662
Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the sodium channel alpha subunit in rat cardiac muscleQ67865283
Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkeyQ68139227
Potassium channels in cardiac cells activated by arachidonic acid and phospholipidsQ69621180
Elevated density and altered pharmacologic properties of myocardial calcium current of the spontaneously hypertensive ratQ71656868
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectfatty acidQ61476
P304page(s)11000-11004
P577publication date1995-11-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleBlocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes
P478volume92

Reverse relations

cites work (P2860)
Q92312174A Switch to Polyunsaturated Fatty Acid Based Ketogenic Diet Improves Seizure Control in Patients with Drug-resistant Epilepsy on the Mixed Fat Ketogenic Diet: A Retrospective Open Label Trial
Q37625453Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels
Q36561749Alexander Leaf, MD (1920-2012)-A tribute to a life in physiology and medicine
Q46496293Antiarrhythmic and electrophysiological effects of long-chain omega-3 polyunsaturated fatty acids
Q35208804Antiarrhythmic effects of omega-3 fatty acids: from epidemiology to bedside
Q82461776Antiarrhythmic mechanisms of n-3 PUFA and the results of the GISSI-Prevenzione trial
Q74446234Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model
Q35595421Antioxidants as a preventive treatment for epileptic process: a review of the current status
Q37321146Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy
Q35029057Blockade by N-3 polyunsaturated fatty acid of the Kv4.3 current stably expressed in Chinese hamster ovary cells
Q37461891Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors
Q38202021Cardiac physiology and clinical efficacy of dietary fish oil clarified through cellular mechanisms of omega-3 polyunsaturated fatty acids.
Q39013780Cardioprotective effects of omega 3 fatty acids: origin of the variability
Q37773594Cardiovascular effects of marine omega-3 fatty acids.
Q33720799Caveolae, ion channels and cardiac arrhythmias
Q40205455Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels.
Q36999779Chronic Omega-3 Polyunsaturated Fatty Acid Treatment Variably Affects Cellular Repolarization in a Healed Post-MI Arrhythmia Model
Q40868070Coexpression with beta(1)-subunit modifies the kinetics and fatty acid block of hH1(alpha) Na(+) channels
Q24645921Connexin channels and phospholipids: association and modulation
Q35067994Could n-3 polyunsaturated fatty acids reduce pathological pain by direct actions on the nervous system?
Q34437887Dampening of hyperexcitability in CA1 pyramidal neurons by polyunsaturated fatty acids acting on voltage-gated ion channels
Q37872360Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example
Q74410074Dietary fish oil prevents asynchronous contractility and alters Ca(2+) handling in adult rat cardiomyocytes
Q28143207Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico
Q33333376Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes
Q37627373Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice.
Q73904167Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes
Q57486424Disease Modifiers of Inherited Channelopathy
Q35834505Docosahexaenoic acid alters bilayer elastic properties.
Q34542831Docosahexaenoic acid: membrane properties of a unique fatty acid
Q37727047Drug-induced ion channel opening tuned by the voltage sensor charge profile
Q24793919Effect of Omacor on HRV parameters in patients with recent uncomplicated myocardial infarction – A randomized, parallel group, double-blind, placebo-controlled trial: study design [ISRCTN75358739]
Q44136449Effects of arachidonic acid on sodium currents in rat dorsal root ganglion neurons
Q73109278Effects of dietary n-3 fatty acids on contractility, Na+ and K+ currents in a rat cardiomyocyte model of arrhythmia
Q43788119Effects of dietary polyunsaturated fatty acids and hepatic steatosis on the functioning of isolated working rat heart under normoxic conditions and during post-ischemic reperfusion
Q33548046Effects of dietary polyunsaturated fatty acids on neuronal function
Q44100282Effects of docosahexaenoic acid on [Ca(2+)](i) increase induced by doxorubicin in ventricular rat cardiomyocytes.
Q53927544Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes.
Q77582091Effects of long-term treatment with eicosapentaenoic acid on the heart subjected to ischemia/reperfusion and hypoxia/reoxygenation in rats
Q36193646Effects of n-3 Polyunsaturated Fatty Acids on Cardiac Ion Channels
Q28192354Efficacy of n-3 polyunsaturated fatty acids after myocardial infarction: results of GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico
Q39893348Eicosapentaenoic acid inhibits voltage-gated sodium channels and invasiveness in prostate cancer cells
Q37815091Electrophysiological mechanisms of the anti-arrhythmic effects of omega-3 fatty acids
Q36957089Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules
Q37661135Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteins
Q28071835Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function
Q35935540Fatty acids suppress voltage-gated Na+ currents in HEK293t cells transfected with the alpha-subunit of the human cardiac Na+ channel
Q35552231Fish oil for the treatment of cardiovascular disease.
Q73141588Inhibition of cardiac sodium currents in adult rat myocytes by n-3 polyunsaturated fatty acids
Q41119269Inhibitory effects of omega-3 polyunsaturated fatty acids on receptor-mediated non-selective cation currents in rat A7r5 vascular smooth muscle cells
Q54587769Lasting alterations of the sodium current by short-term hyperlipidemia as a mechanism for initiation of cardiac remodeling.
Q44383116Linoleic acid metabolites act to increase contractility in isolated rat heart
Q41877460Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids
Q34358857Long chain polyunsaturated fatty acids alter oxytocin signaling and receptor density in cultured pregnant human myometrial smooth muscle cells
Q33559941Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model
Q53814626Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains.
Q92703441Marine-Derived Omega-3 Polyunsaturated Fatty Acids and Heart Failure: Current Understanding for Basic to Clinical Relevance
Q37617083May the best friend be an enemy if not recognized early: possible role of omega-3 against cardiovascular abnormalities due to antipsychotics in the treatment of autism
Q36445341Mechanism of arachidonic acid modulation of the T-type Ca2+ channel alpha1G
Q30666183Mechanisms of action of docosahexaenoic acid in the nervous system
Q54408051Mechanisms of cell death of thymocytes induced by polyunsaturated, monounsaturated and trans-fatty acids.
Q33993322Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias
Q45147815Membrane fluidity changes are associated with the antiarrhythmic effects of docosahexaenoic acid in adult rat cardiomyocytes
Q46870930Mitochondrial basis of the anti-arrhythmic action of lidocaine and modulation by the n-6 to n-3 PUFA ratio of cardiac phospholipids
Q46836414Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid
Q46737132Neuroprotective activity of omega-3 fatty acids against epilepsy-induced hippocampal damage: Quantification with immunohistochemical for calcium-binding proteins
Q33890925Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in dorsal root ganglion neurons from adult male rats
Q36115396Omega-3 fatty acid supplementation appears to attenuate particulate air pollution-induced cardiac effects and lipid changes in healthy middle-aged adults
Q38930015Omega-3 fatty acids (ω-3 fatty acids) in epilepsy: animal models and human clinical trials
Q38498202Omega-3 fatty acids, lipid rafts, and T cell signaling
Q48156357Omega-3 intake in people with obstructive sleep apnea: beauty sleep for the heart
Q34887291Omega-3 polyunsaturated fatty acids inhibit transient outward and ultra-rapid delayed rectifier K+currents and Na+current in human atrial myocytes
Q39715633Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research
Q42042951Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes
Q36254295Polyunsaturated Fatty acids in atrial fibrillation: looking for the proper candidates.
Q38042919Polyunsaturated Fatty acids modify the gating of kv channels
Q31089779Polyunsaturated dietary fats change the properties of calcium sparks in adult rat atrial myocytes
Q90619103Polyunsaturated fatty acid analogues differentially affect cardiac Nav, Cav, and Kv channels through unique mechanisms
Q37284621Polyunsaturated fatty acids and their effects on cardiovascular disease
Q71709239Polyunsaturated fatty acids exert antiarrhythmic actions as free acids rather than in phospholipids
Q73118879Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation
Q37243012Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons
Q40365076Potent block of inactivation-deficient Na+ channels by n-3 polyunsaturated fatty acids
Q73938542Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs
Q35143363Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids
Q37370040Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: a meta-analysis of randomized controlled trials
Q33161872Protective role of Ashwagandharishta and flax seed oil against maximal electroshock induced seizures in albino rats
Q80351853Protein kinase A is activated by the n-3 polyunsaturated fatty acid eicosapentaenoic acid in rat ventricular muscle
Q58001319Rapid adaptation of Rhodococcus erythropolis cells to salt stress by synthesizing polyunsaturated fatty acids
Q37634286Reduced Glycemic Variability in Diazoxide-Responsive Children with Congenital Hyperinsulinism Using Supplemental Omega-3-Polyunsaturated Fatty Acids; A Pilot Trial with MaxEPA(R.).
Q36355384Reduction of heart rate by omega-3 fatty acids and the potential underlying mechanisms
Q36055973Regulation of sodium channel gene expression by class I antiarrhythmic drugs and n - 3 polyunsaturated fatty acids in cultured neonatal rat cardiac myocytes
Q34252062Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism
Q91683502Resolution of a therapy-resistant focal atrial tachycardia after omega-3 fatty acid supplementation
Q41811863Role of redox state in modulation of ion channel function by fatty acids and phospholipids
Q34756665Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels
Q44729149Suppression of calcium sparks in rat ventricular myocytes and direct inhibition of sheep cardiac RyR channels by EPA, DHA and oleic acid
Q36111398Suppression of voltage-gated L-type Ca2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes
Q50971812Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Q40220632TRPV1 is a novel target for omega-3 polyunsaturated fatty acids
Q51398333Termination of asynchronous contractile activity in rat atrial myocytes by n-3 polyunsaturated fatty acids.
Q35890108The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium Channel
Q90206447The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3
Q41987929The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system
Q36386156The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation of cardiac ion channels as a potential mechanism
Q71319545The cardiac antiarrhythmic effects of polyunsaturated fatty acid
Q35865078The effects of supplementation with omega-3 polyunsaturated Fatty acids on cardiac rhythm: anti-arrhythmic, pro-arrhythmic, both or neither? It depends…
Q46610835The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to omega3 polyunsaturated fatty acids
Q34524185The electrophysiologic basis for the antiarrhythmic and anticonvulsant effects of n-3 polyunsaturated fatty acids: heart and brain
Q37176865The other side of the coin: Beneficiary effect of omega-3 fatty acids in sudden unexpected death in epilepsy.
Q28248377The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling
Q37848108The utility of omega-3 fatty acids in epilepsy: more than just a farmed tilapia!
Q46448157Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts
Q34441990Voltage-dependent calcium channels--beyond dihydropyridine antagonists.
Q36064570Why Do We Still Need Large Scale Clinical Trial: The Case of n-3 PUFA.
Q36052600n-3 (omega-3) polyunsaturated fatty acids prevent acute atrial electrophysiological remodeling
Q81657680n-3 fatty acids (eicosapentanoic and docosahexanoic acids) in epilepsy and for the prevention of sudden unexpected death in epilepsy
Q33695192n-3 fatty acids in the prevention of cardiac arrhythmias
Q46575091{Omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channels
Q64928631ω-6 and ω-9 polyunsaturated fatty acids with double bonds near the carboxyl head have the highest affinity and largest effects on the cardiac IK s potassium channel.

Search more.