Overcoming Challenges With Statin Therapy

scientific article

Overcoming Challenges With Statin Therapy is …
instance of (P31):
scholarly articleQ13442814
case reportQ2782326
review articleQ7318358

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P356DOI10.1161/JAHA.115.002497
P3181OpenCitations bibliographic resource ID4249838
P932PMC publication ID4859367
P698PubMed publication ID26819251
P5875ResearchGate publication ID292187604

P50authorGeorge K DresserQ116469852
J. David SpenceQ43094507
P2860cites workSLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acidQ57825144
Carotid Ultrasound Phenotypes Are Biologically DistinctQ58769489
Statins and Cataracts: Reverse Causality?Q58769544
Effects of Intensive Medical Therapy on Microemboli and Cardiovascular Risk in Asymptomatic Carotid StenosisQ58770328
Preventing Dementia by Treating Hypertension and Preventing StrokeQ58771247
Carotid Plaque Area and Intima-Media Thickness in Prediction of First-Ever Ischemic StrokeQ63380980
Drug interactions with grapefruit: whose responsibility is it to warn the public?Q73293609
Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemiaQ79272110
High-dose atorvastatin after stroke or transient ischemic attackQ80088259
[Reduced synthesis of coenzyme Q10 may cause statin related myopathy]Q82556884
Effects of rosuvastatin and atorvastatin on renal function: meta-analysisQ83552572
Effect of coenzyme Q10 supplementation on statin-induced myalgiasQ84169460
Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise enduranceQ84268559
Discontinuation of statin therapy due to muscular side effects: a survey in real lifeQ84501478
Balancing the cardiometabolic benefits and risks of statinsQ84774071
Improvement of statin-associated myotoxicity by L-carnitineQ45197186
Ezetimibe and regression of carotid atherosclerosis: importance of measuring plaque burdenQ45719462
Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus.Q45925043
Effect of L-carnitine on the size of low-density lipoprotein particles in type 2 diabetes mellitus patients treated with simvastatin.Q45928533
Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in IsraelQ46183486
Statin usage and all-cause and disease-specific mortality in a nationwide studyQ46421039
Pharmacokinetics of rosuvastatin when coadministered with rifampicin in healthy males: a randomized, single-blind, placebo-controlled, crossover study.Q46436953
The safety of rosuvastatin as used in common clinical practice: a postmarketing analysisQ46505797
Metabolic myopathies discovered during investigations of statin myopathy.Q46671140
Lipid profile, statin use, and outcome after intravenous thrombolysis for acute ischaemic stroke.Q46704364
Lipid profiles and outcome in patients treated by intravenous thrombolysis for cerebral ischemiaQ47328159
Statins do not cause intracerebral hemorrhageQ48424813
Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam StudyQ48874488
Impact of Dual Lipid-Lowering Strategy With Ezetimibe and Atorvastatin on Coronary Plaque Regression in Patients With Percutaneous Coronary Intervention: The Multicenter Randomized Controlled PRECISE-IVUS TrialQ50439115
Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy.Q50711584
Myopathy during statin therapy in the daily practice of an outpatient cardiology clinic: prevalence, predictors and relation with vitamin D.Q50937715
Treating arteries instead of risk factors: a paradigm change in management of atherosclerosis.Q51144514
Statins and intracerebral hemorrhage: a retrospective cohort study.Q53088871
Adherence to statin treatment and health outcomes in an Italian cohort of newly treated patients: results from an administrative database analysis.Q53675601
Ethanol enhances the hemodynamic effects of felodipine.Q54339719
Coenzyme Q(10) and selenium in statin-associated myopathy treatment.Q54446305
Accumulating evidence for statins in primary prevention.Q54535531
Weighing the benefits of high-dose simvastatin against the risk of myopathy.Q54581421
Statin Use and the Risk of Incident DementiaQ57392350
Effects of atorvastatin and rosuvastatin on renal function: A meta-analysisQ57618829
Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanismQ24603957
C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20,536 patients in the Heart Protection StudyQ24617734
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosisQ24629045
Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatinQ24679132
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and ManagementQ28083004
Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatinQ28142865
Statins and stroke preventionQ28166611
A statin-dependent QTL for GATM expression is associated with statin-induced myopathyQ28218899
Squalene synthase inhibitors: An update on the search for new antihyperlipidemic and antiatherosclerotic agentsQ28246326
Human skeletal muscle drug transporters determine local exposure and toxicity of statinsQ28265844
Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant dataQ28742740
Mitochondrial respiratory-chain diseasesQ29614474
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trialsQ29617910
SLCO1B1 variants and statin-induced myopathy--a genomewide studyQ29619028
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuidelinesQ29620108
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trialsQ29622947
Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory studyQ30417962
Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases.Q33685412
Effects of lovastatin on cognitive function and psychological well-beingQ33901538
Effect of coenzyme q10 on myopathic symptoms in patients treated with statinsQ34004066
Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysisQ34027392
The association of statin use and statin type and cognitive performance: analysis of the reasons for geographic and racial differences in stroke (REGARDS) studyQ34078486
Statin-associated myopathyQ34187996
Is statin-associated cognitive impairment clinically relevant? A narrative review and clinical recommendationsQ34219598
Effect of a monoclonal antibody to PCSK9 on LDL cholesterolQ34262650
Targeting cellular energy production in neurological disordersQ34266266
The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.Q34276618
Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trialQ34293369
Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathologyQ37579479
Drug interactions with HMG-CoA reductase inhibitors (statins): the importance of CYP enzymes, transporters and pharmacogenetics.Q37697094
The myth of statin-induced hepatotoxicityQ37743155
Coenzyme q10 and statin-induced mitochondrial dysfunction.Q37878308
Statins and intracerebral hemorrhage: collaborative systematic review and meta-analysis.Q37946869
Novel LDL-oriented pharmacotherapeutical strategies.Q37981532
Monogenic mitochondrial disordersQ37995644
Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspectsQ38026944
Association of statin use with risk of dementia: a meta-analysis of prospective cohort studiesQ38086584
Current Phase II proprotein convertase subtilisin/kexin 9 inhibitor therapies for dyslipidemiaQ38124404
New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: what can the clinician expect?Q38126418
Statins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effectsQ38149604
Carnitine therapy for the treatment of metabolic syndrome and cardiovascular disease: evidence and controversiesQ38212467
Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trialsQ38550677
Persistence and determinants of statin therapy among middle-aged patients free of cardiovascular diseaseQ40390462
Grapefruit juice-drug interactions. 1998.Q42092985
Liver tests are irrelevant when prescribing statinsQ42791971
Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysisQ42791977
Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart DiseaseQ42807626
Oral acetyl-L-carnitine therapy and insulin resistanceQ43075364
Impact of statin use and lipid profile on symptomatic intracerebral haemorrhage, outcome and mortality after intravenous thrombolysis in acute strokeQ43483709
Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemiaQ44264759
Effect of pravastatin on loss of renal function in people with moderate chronic renal insufficiency and cardiovascular diseaseQ44449846
Compliance and persistence with concomitant statin and oral antihyperglycemic therapy.Q44508293
Long term persistence with statin therapy -- experience in Australia 2006-2010.Q44528592
Previous statin use is not associated with an increased prevalence or degree of gradient-echo lesions in patients with acute ischemic stroke or transient ischemic attackQ44532987
Statin-associated rhabdomyolysis triggered by grapefruit consumptionQ44774923
Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6226 persons: the Tromsø StudyQ44902257
Adherence to guideline-recommended therapy is associated with decreased major adverse cardiovascular events and major adverse limb events among patients with peripheral arterial disease.Q34297015
Safety of statins: focus on clinical pharmacokinetics and drug interactionsQ34327120
Statin toxicity from macrolide antibiotic coprescription: a population-based cohort studyQ34351776
Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adultsQ34374952
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trialQ34375398
Statins and cognitive function: a systematic reviewQ34386044
Diagnosis, prevention, and management of statin adverse effects and intolerance: Canadian Working Group Consensus updateQ34387237
Statin therapy for primary prevention of cardiovascular diseaseQ34387879
Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trialsQ34450426
Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acidQ34467998
Ezetimibe Added to Statin Therapy after Acute Coronary SyndromesQ34479098
Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO studyQ34490730
Genetic risk factors associated with lipid-lowering drug-induced myopathiesQ34521375
Interaction of citrus juices with felodipine and nifedipineQ34567652
Antifatigue effects of coenzyme Q10 during physical fatigueQ34588341
Drug interactions with lipid-lowering drugs: mechanisms and clinical relevanceQ34592657
The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy.Q34613443
Discontinuation of statins in routine care settings: a cohort studyQ34644409
Genetically elevated C-reactive protein and ischemic vascular diseaseQ34868720
Benefit-risk assessment of Rosuvastatin 10 to 40 milligramsQ35209314
Clinical pharmacokinetics of statinsQ35209512
Mechanisms of statin-induced myalgia assessed by physiogenomic associationsQ35575560
The effect of statins versus untreated dyslipidaemia on renal function in patients with coronary heart disease. A subgroup analysis of the Greek atorvastatin and coronary heart disease evaluation (GREACE) study.Q35587723
Evaluation of C-reactive protein prior to and on-treatment as a predictor of benefit from atorvastatin: observations from the Anglo-Scandinavian Cardiac Outcomes TrialQ35756468
Persistence and determinants of statin therapy among middle-aged patients for primary and secondary preventionQ35826989
Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force.Q36438054
Statins for improving renal outcomes: a meta-analysisQ36500899
Approaches to the treatment of mitochondrial diseasesQ36524103
A randomized trial of coenzyme Q10 in patients with statin myopathy: rationale and study designQ36899354
Simvastatin impairs exercise training adaptationsQ37100826
Effects of simvastatin 40 mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk peopleQ37177038
Molecular basis of statin-associated myopathyQ37202013
Statin myopathy as a metabolic muscle diseaseQ37230388
Genetic predisposition to statin myopathyQ37306393
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcardiovascular diseaseQ389735
muscular diseaseQ692536
statinQ954845
insulin resistanceQ1053470
lipidQ11367
diabetesQ12206
statin therapyQ62562875
dyslipidemiaQ66291209
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)e002497
P577publication date2016-01-27
P1433published inJournal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseQ19880670
P1476titleOvercoming Challenges With Statin Therapy
P478volume5

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cites work (P2860)
Q88766431A comprehensive review and meta-analysis of risk factors for statin-induced myopathy
Q41678728Appropriate management of asymptomatic carotid stenosis
Q60301234Association of medication adherence and depression with the control of low-density lipoprotein cholesterol and blood pressure in patients at high cardiovascular risk
Q58769018Controlling resistant hypertension
Q55292729Free triiodothyronine level correlates with statin responsiveness in acute myocardial infarction.
Q26740304Recent advances in pathogenesis, assessment, and treatment of atherosclerosis
Q99630523Recent advances in preventing recurrent stroke
Q33873364Recent advances in preventing stroke recurrence
Q64062792Statins and Inflammation: New Therapeutic Opportunities in Psychiatry
Q90224258The Signaling Pathways Involved in the Antiatherosclerotic Effects Produced by Chinese Herbal Medicines
Q47255965Treatment patterns and low-density lipoprotein cholesterol (LDL-C) goal attainment among patients receiving high- or moderate-intensity statins

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