C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20,536 patients in the Heart Protection Study

scientific article

C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20,536 patients in the Heart Protection Study is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0140-6736(10)62174-5
P932PMC publication ID3042687
P698PubMed publication ID21277016

P50authorRory Edwards CollinsQ7366866
John DaneshQ22277498
Sarah ParishQ86996408
P2093author name stringDerrick Bennett
Jonathan Emberson
Jane Armitage
Emma Link
P2860cites workAtherosclerosis — An Inflammatory DiseaseQ26776972
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trialQ28214393
Inflammation, atherosclerosis, and coronary artery diseaseQ29547232
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive proteinQ29547752
Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statinsQ29547856
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trialsQ29617910
The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: an updated meta-analysisQ33420117
MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trialQ33960122
Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trialsQ34157981
Reliable assessment of the effects of treatment on mortality and major morbidity, II: observational studiesQ34198010
Current concepts of the pathogenesis of the acute coronary syndromesQ34310339
Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trialQ34550538
Low-density lipoprotein-dependent and -independent effects of cholesterol-lowering therapies on C-reactive protein: a meta-analysisQ34629713
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysisQ35182277
Chemical, pharmacokinetic and pharmacodynamic properties of statins: an updateQ36014966
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysisQ37717921
By Jove! What is a clinician to make of JUPITER?Q37768304
Effects of statin therapy according to plasma high-sensitivity C-reactive protein concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA): a retrospective analysisQ38377634
Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER).Q38467359
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trialQ38473723
Lipoprotein-associated phospholipase A₂ activity and mass in relation to vascular disease and nonvascular mortalityQ42836650
Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary eventsQ43656468
C-reactive protein levels and outcomes after statin therapyQ45213511
Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators.Q50866439
Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score.Q51922378
MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experienceQ56336748
Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) InvestigatorsQ78017116
P433issue9764
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
statin therapyQ62562875
P304page(s)469-76
P577publication date2011-02-05
P1433published inThe LancetQ939416
P1476titleC-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20,536 patients in the Heart Protection Study
P478volume377

Reverse relations

cites work (P2860)
Q36721590A Novel Medical Treatment for Lipid Control in Patients with Unstable Angina Pectoris and Statin-Induced Liver Dysfunction.
Q38134084Almost everyone over 50 should be put on a statin to reduce the risk of cardiovascular disease: A protagonist view.
Q34095488Anti-inflammatory and anti-thrombogenic effects of atorvastatin in acute ischemic stroke
Q92610593Association Between Baseline, Achieved, and Reduction of CRP and Cardiovascular Outcomes After LDL Cholesterol Lowering with Statins or Ezetimibe: A Systematic Review and Meta-Analysis
Q37000223Association of malnutrition-inflammation complex and responsiveness to erythropoiesis-stimulating agents in long-term hemodialysis patients
Q35213010Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort study
Q90013033Atherosclerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and Related Risk Factor in Patient with Dyslipidemia
Q38072595Between risk charts and imaging: how should we stratify cardiovascular risk in clinical practice?
Q83810410Biomarkers: Is CRP level useful to guide statin therapy? Lack of evidence from HPS fuels the debate
Q84275088C-reactive protein in the Heart Protection Study
Q57496180C-reactive protein in the Heart Protection Study – Authors' reply
Q35101153C-reactive protein levels in patients at cardiovascular risk: EURIKA study
Q37021409C-reactive protein, fibrinogen, and cardiovascular disease prediction
Q37906353C-reactive protein, statins and the risk of vascular events: a better understanding
Q95633714Clinical approach to the inflammatory etiology of cardiovascular diseases
Q38880500Clinical relevance for lowering C-reactive protein with statins.
Q26764766Clinical relevance of high sensitivity C-reactive protein in cardiology
Q35153209Coexistence of low vitamin D and high fibroblast growth factor-23 plasma levels predicts an adverse outcome in patients with coronary artery disease
Q38049066Dyslipidemia: management using optimal lipid-lowering therapy
Q35757048Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial
Q45191361Effects of low-fat or full-fat fermented and non-fermented dairy foods on selected cardiovascular biomarkers in overweight adults.
Q42021710Effects of pitavastatin on walking capacity and CD34+/133+ cell number in patients with peripheral artery disease
Q44973053Effects of rosuvastatin on subclinical atherosclerosis and arterial stiffness in rheumatoid arthritis: a randomized controlled pilot trial
Q52886658Effects of simvastatin and ezetimibe on interleukin-6 and high-sensitivity C-reactive protein.
Q52371615Elevated Levels of Serum β2-Glycoprotein I/Oxidized Low-Density Lipoprotein Complexes Are Associated with Cerebral Infarction in Patients with Type 2 Diabetes Mellitus.
Q35756468Evaluation of C-reactive protein prior to and on-treatment as a predictor of benefit from atorvastatin: observations from the Anglo-Scandinavian Cardiac Outcomes Trial
Q38233001High-Sensitivity C-Reactive Protein and Statin Initiation.
Q34516430Homocysteine levels and treatment effect in the PROspective Study of Pravastatin in the Elderly at Risk
Q38176273How low an LDL-C should we go with statin therapy?
Q37586959Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life
Q26865722Identifying novel biomarkers for cardiovascular disease risk prediction
Q90389973Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology
Q30731532Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial)
Q37947242Inflammatory markers in coronary heart disease
Q36637949Influence of atherosclerosis-related risk factors on serum high-sensitivity C-reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non-obese patients
Q47394637Lowering LDL cholesterol reduces cardiovascular risk independently of presence of inflammation
Q45822783Meta-Analysis Comparing Rosuvastatin and Atorvastatin in Reducing Concentration of C-Reactive Protein in Patients With Hyperlipidemia
Q50890395Metabolic syndrome in the prediction of cardiovascular events: the potential additive role of hsCRP and adiponectin.
Q97559552Multimarker approach including CRP, sST2 and GDF-15 for prognostic stratification in stable heart failure
Q28073319Overcoming Challenges With Statin Therapy
Q36247131Reducing serum cholesterol levels in women
Q100525999Reduction in hsCRP levels is associated with decreased incidence of cardiovascular events in Japanese hypertensive women but not in men
Q37962460Role of C-reactive protein when prescribing a statin
Q33922922Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein.
Q34812017Statin therapy after infrainguinal bypass surgery for critical limb ischemia is associated with improved 5-year survival
Q36088110Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials.
Q24201513Statins for the primary prevention of cardiovascular disease
Q37883015Statins, inflammation and kidney disease
Q38462688The JUPITER trial: myth or reality?
Q41967368The effect of periodontal treatment on C-reactive protein: A clinical study.
Q38106872The immune system in stroke: clinical challenges and their translation to experimental research
Q35866695The role and clinical significance of high-sensitivity C-reactive protein in cardiovascular disease
Q34665888Time variability of C-reactive protein: implications for clinical risk stratification
Q45125528Treatment of patients with intermediate cardiovascular risk: Are clinical measures enough?
Q53669745Under-reporting of venous and arterial thrombotic events in randomized clinical trials: a meta-analysis.
Q39215606Vascular inflammation and low-density lipoproteins: is cholesterol the link? A lesson from the clinical trials

Search more.