Type 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal cilia

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Type 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal cilia is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P932PMC publication ID5078481
P698PubMed publication ID27785336

P2093author name stringChen X
Qiu L
Storm DR
LeBel RP
P2860cites workFlagellar synchronization through direct hydrodynamic interactionsQ21128775
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The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensationQ28000035
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Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic miceQ28142480
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Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signalsQ28285141
Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivoQ28289372
The type 3 adenylyl cyclase is required for the survival and maturation of newly generated granule cells in the olfactory bulbQ28390576
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Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary ciliaQ28513272
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Adenylyl cyclases and the interaction between calcium and cAMP signallingQ40496494
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Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depressionQ42439958
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Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase.Q42825721
Ciliary dysfunction and obesityQ43227936
Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteriesQ43606187
Adenylyl cyclase 3 mediates prostaglandin E(2)-induced growth inhibition in arterial smooth muscle cellsQ43658451
Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat.Q44329653
Odorant-induced and sniff-induced activation in the cerebellum of the human.Q46597273
Difference in physiogenomics between male and female infertilityQ46598174
Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brainQ46959770
Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men.Q46981721
Ablation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like PhenotypesQ47888461
Sniffing controls an adaptive filter of sensory input to the olfactory bulb.Q48193538
Olfaction as a marker for depression in humansQ48367564
The olfactory adenylyl cyclase type 3 is expressed in male germ cellsQ48491838
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Transducing emotionality: the role of adenylyl cyclasesQ48612174
Olfactory bulb units: activity correlated with inhalation cycles and odor quality.Q51107825
Sniffing longer rather than stronger to maintain olfactory detection thresholdQ73431600
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Central nervous system control of metabolism.Q38059776
Primary cilia and graded Sonic Hedgehog signalingQ38116920
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Influences of primary cilia on cortical morphogenesis and neuronal subtype maturationQ38205163
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'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexusQ38789681
Ciliary adenylyl cyclases control the Hedgehog pathwayQ38861982
Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1.Q39184362
Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptorsQ28577465
Identification of a specialized adenylyl cyclase that may mediate odorant detectionQ28581625
Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney diseaseQ28585961
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signalingQ28589325
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseasesQ28591325
Hedgehog signalling in the mouse requires intraflagellar transport proteinsQ28593010
Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagellaQ28593253
When cilia go bad: cilia defects and ciliopathiesQ29547198
The vertebrate primary cilium in development, homeostasis, and diseaseQ29614609
Proteomic analysis of a eukaryotic ciliumQ29614823
The primary cilium as the cell's antenna: signaling at a sensory organelleQ29615165
Adenylate cyclase 3: a new target for anti-obesity drug developmentQ30249873
Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibitionQ30407430
dTULP, the Drosophila melanogaster homolog of tubby, regulates transient receptor potential channel localization in cilia.Q30448964
Why sniff fast? The relationship between sniff frequency, odor discrimination, and receptor neuron activation in the rat.Q30483660
C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channelQ30496277
Chemically inducible diffusion trap at cilia reveals molecular sieve-like barrier.Q30560329
G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neuronsQ30616611
The type III calcium/calmodulin-sensitive adenylyl cyclase is not specific to olfactory sensory neuronsQ31001112
Force generation and dynamics of individual cilia under external loadingQ33568368
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.Q33911593
Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cellsQ33933817
Regulation and role of adenylyl cyclase isoformsQ33939373
Genetic architectures of psychiatric disorders: the emerging picture and its implicationsQ33949729
Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cellsQ34017092
Primary cilia are required in a unique subpopulation of neural progenitorsQ34119929
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learnedQ34147518
A cyclic nucleotide-gated conductance in olfactory receptor ciliaQ34162894
Intraflagellar transport and cilia-dependent diseases.Q34166357
Cilia in the CNS: the quiet organelle claims center stageQ34173153
All in a sniff: olfaction as a model for active sensingQ34219082
Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP.Q34319558
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposityQ34330305
Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.Q34355892
How the olfactory system makes sense of scentsQ34370087
Sniffing and smelling: separate subsystems in the human olfactory cortexQ34461883
Maternal behavior is impaired in female mice lacking type 3 adenylyl cyclaseQ34662005
Central role of soluble adenylyl cyclase and cAMP in sperm physiology.Q34674355
Controlling fertilization and cAMP signaling in sperm by optogenetics.Q34983253
The vertebrate primary cilium is a sensory organelleQ35041118
Calmodulin-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous systemQ35073678
Isoforms of mammalian adenylyl cyclase: multiplicities of signalingQ35679436
A genome-wide association study of body mass index across early life and childhoodQ35749372
Meta-analysis identifies common variants associated with body mass index in east AsiansQ35785297
Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney diseaseQ36156370
The sniff as a unit of olfactory processing.Q36336756
Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease?Q36337939
Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclaseQ36423132
Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors.Q36430246
Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitabilityQ36514620
Hepatic adenylate cyclase 3 is upregulated by Liraglutide and subsequently plays a protective role in insulin resistance and obesityQ36548301
Primary cilia are not calcium-responsive mechanosensorsQ36852774
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass indexQ36861322
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signalingQ36861834
High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.Q36916014
Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal CiliaQ36948633
The retinal ciliopathies.Q36951820
Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targetingQ36966260
Testing the sorption hypothesis in olfaction: a limited role for sniff strength in shaping primary odor representations during behavior.Q37008405
The sensory cilia of Caenorhabditis elegansQ37020826
Functional expression of the olfactory signaling system in the kidneyQ37100981
Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathwayQ37381625
Capturing adenylyl cyclases as potential drug targetsQ37428727
Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo.Q37594004
Mechanics of microtubules.Q37611250
Olfactory signalling in vertebrates and insects: differences and commonalitiesQ37690116
Structure and function of vertebrate cilia, towards a new taxonomy.Q37961285
Targeting neuronal adenylyl cyclase for the treatment of chronic painQ37992353
Synaptic dysfunction in depression: potential therapeutic targetsQ38050123
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)95-108
P577publication date2016-09-30
P1476titleType 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal cilia
P478volume8

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cites work (P2860)
Q64260759Comparative Phosphoproteomic Profiling of Type III Adenylyl Cyclase Knockout and Control, Male, and Female Mice
Q89980676Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults
Q42363242Drosophila Model for the Analysis of Genesis of LIM-kinase 1-Dependent Williams-Beuren Syndrome Cognitive Phenotypes: INDELs, Transposable Elements of the Tc1/Mariner Superfamily and MicroRNAs.
Q55515250Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial.
Q57040563Neuronal and Astrocytic Primary Cilia in the Mature Brain
Q49721704Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain

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