Ablation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like Phenotypes

scientific article published on 19 December 2015

Ablation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like Phenotypes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BIOPSYCH.2015.12.012
P932PMC publication ID5972377
P698PubMed publication ID26868444
P5875ResearchGate publication ID287512684

P50authorLarry S ZweifelQ52551331
Yihua LengQ58048295
Jie LuoQ58048300
P2093author name stringRichard D Palmiter
Daniel R Storm
Xuanmao Chen
Yimei Yang
P2860cites workAdult type 3 adenylyl cyclase-deficient mice are obeseQ27342322
Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic miceQ28142480
Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human plateletsQ28181440
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell lossQ28274165
The primary cilium as the cell's antenna: signaling at a sensory organelleQ29615165
Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibitionQ30407430
Disruption of dopamine neuron activity pattern regulation through selective expression of a human KCNN3 mutation.Q30425716
Olfactory deficits cause anxiety-like behaviors in miceQ30461093
A role for primary cilia in glutamatergic synaptic integration of adult-born neuronsQ30505760
Visualization of plasticity in fear-evoked calcium signals in midbrain dopamine neurons.Q30593949
Hippocampal volume and depression: a meta-analysis of MRI studiesQ30974294
Genetic epidemiology of major depression: review and meta-analysisQ33919509
Depression, antidepressants, and the shrinking hippocampusQ33947617
Functional modifications of acid-sensing ion channels by ligand-gated chloride channelsQ33971181
Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalographyQ34000026
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learnedQ34147518
Blood transcriptomic biomarkers in adult primary care patients with major depressive disorder undergoing cognitive behavioral therapy.Q34345609
Pheromone detection in male mice depends on signaling through the type 3 adenylyl cyclase in the main olfactory epithelium.Q34547020
The burden of depression and anxiety in general medicine.Q34729020
From monoamines to genomic targets: a paradigm shift for drug discovery in depressionQ35709598
Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclaseQ36423132
Adult hippocampal neurogenesis in depressionQ36921967
Functional expression of the olfactory signaling system in the kidneyQ37100981
Depression and hippocampal neurogenesis: a road to remission?Q37131367
Cognitive role of neurogenesis in depression and antidepressant treatmentQ37210811
Diarylamidines: high potency inhibitors of acid-sensing ion channelsQ37356377
Cognitive dysfunction in depression: neurocircuitry and new therapeutic strategiesQ37894311
A meta-analysis of electroencephalographic sleep in depression: evidence for genetic biomarkersQ37936597
Bidirectional association between depression and sexual dysfunction: a systematic review and meta-analysisQ37998526
Synaptic dysfunction in depression: potential therapeutic targetsQ38050123
REM sleep dysregulation in depression: state of the art.Q38079910
βCaMKII in lateral habenula mediates core symptoms of depressionQ41899899
Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depressionQ42439958
Platelet adenylyl cyclase activity: a biological marker for major depression and recent drug use.Q42482528
Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.Q42524386
Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase.Q42825721
Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studiesQ44066592
Age at onset and familial risk for major depression in a Swedish national twin sampleQ44914246
Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brainQ46959770
State-dependent changes in hippocampal grey matter in depressionQ48307194
Transducing emotionality: the role of adenylyl cyclasesQ48612174
Subgenual prefrontal cortex abnormalities in mood disordersQ48725544
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortexQ69419174
The symptoms of major depressive illnessQ71425334
Lower hippocampal volume in patients suffering from depression: a meta-analysisQ79851071
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)836-848
P577publication date2015-12-19
P1433published inBiological PsychiatryQ4914961
P1476titleAblation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like Phenotypes
P478volume80

Reverse relations

cites work (P2860)
Q61448715A Flow Cytometry-Based Approach for the Isolation and Characterization of Neural Stem Cell Primary Cilia
Q64260759Comparative Phosphoproteomic Profiling of Type III Adenylyl Cyclase Knockout and Control, Male, and Female Mice
Q48014029Depression and Adenylyl Cyclase: Sorting Out the Signals
Q37486011Disruption of type 3 adenylyl cyclase expression in the hypothalamus leads to obesity
Q89980676Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults
Q92504184Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression
Q92684514Induction of activity synchronization among primed hippocampal neurons out of random dynamics is key for trace memory formation and retrieval
Q55515250Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial.
Q39158851International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.
Q47745542Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
Q47375165Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.
Q57040563Neuronal and Astrocytic Primary Cilia in the Mature Brain
Q49721704Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain
Q100454900Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
Q36948633Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia
Q28073873Type 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal cilia

Search more.