The Role of Toll-Like Receptors in Hematopoietic Malignancies

scientific article

The Role of Toll-Like Receptors in Hematopoietic Malignancies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2016.00390
P3181OpenCitations bibliographic resource ID3291424
P932PMC publication ID5039188
P698PubMed publication ID27733853

P2093author name stringDarlene A. Monlish
Laura G. Schuettpelz
Sima T. Bhatt
P2860cites workDiscrimination of bacterial lipoproteins by Toll-like receptor 6Q24291383
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...Q24297037
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteinsQ24300005
Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cellsQ24658240
Human lung cancer cells express functionally active Toll-like receptor 9Q24802960
Unraveling the Pathogenesis of MDS: The NLRP3 Inflammasome and Pyroptosis Drive the MDS PhenotypeQ26744481
Myelodysplastic syndromes: 2015 Update on diagnosis, risk-stratification and managementQ26796240
Deconstructing innate immune signaling in myelodysplastic syndromesQ26991974
Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodesQ57194638
'TaiLoRing' the response of dendritic cells to pathogensQ57275464
Association study of a functional Toll-like receptor 4 polymorphism with susceptibility to gastric mucosa-associated lymphoid tissue lymphomaQ57569182
The roles of adoptive and active forms of immunotherapy in the cure of children suffering from acute lymphoid leukemia: a) underestimation of active immunotherapy benefit, b) its immunogenetic indications to select sensitive patients, hence preventQ77429957
Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrowQ78460549
Toll-like receptor-4 is up-regulated in hematopoietic progenitor cells and contributes to increased apoptosis in myelodysplastic syndromesQ79819381
Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma riskQ80259660
Proinflammatory response of human leukemic cells to dsRNA transfection linked to activation of dendritic cellsQ80382738
Toll-like receptors (TLRs) are expressed by myeloid leukaemia cell lines, but fail to trigger differentiation in response to the respective TLR ligandsQ84392005
MYD88 Mutations and Response to Ibrutinib in Waldenström's MacroglobulinemiaQ85732520
Demand-adapted regulation of early hematopoiesis in infection and inflammationQ27011458
Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromesQ27015288
Proinflammatory signaling regulates hematopoietic stem cell emergence.Q27324011
Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signallingQ27661754
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.Q27851888
Ibrutinib in previously treated Waldenström's macroglobulinemia.Q27853148
Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapyQ28067939
Different Toll-Like Receptor Expression Patterns in Progression toward CancerQ28085163
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signalingQ28259810
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomesQ28270473
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9Q28292044
Oncogenically active MYD88 mutations in human lymphomaQ28301648
Identification of Lps2 as a key transducer of MyD88-independent TIR signallingQ28587545
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4Q28611075
Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammationQ28742707
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemiaQ29614659
Myelodysplastic syndromes: Contemporary review and how we treatQ33429195
Toll-like receptor alterations in myelodysplastic syndromeQ33572616
Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistanceQ33755300
Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumorsQ33824623
Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signalingQ33857117
Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation.Q33978723
Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesisQ33993410
DAMPening inflammation by modulating TLR signallingQ34035570
Functional diversity of stem and progenitor cells with B-lymphopoietic potentialQ34083743
Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesisQ34106812
Toll-like receptor-4 signaling in mantle cell lymphoma: effects on tumor growth and immune evasionQ34415459
Chronic TLR signaling impairs the long-term repopulating potential of hematopoietic stem cells of wild type but not Id1 deficient miceQ34577180
Chronic exposure to a TLR ligand injures hematopoietic stem cellsQ34907233
Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromesQ34970662
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotypeQ35011883
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishmentQ35113561
Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer.Q35197371
The role of TLR8 signaling in acute myeloid leukemia differentiationQ35288072
Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signalingQ35803662
The Role of TLR2 in Infection and ImmunityQ35927566
Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesotheliomaQ36074728
Antagonist-mediated down-regulation of Toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus.Q36245824
TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidaseQ36259614
Differential constitutive and cytokine-modulated expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophagesQ36389463
TLR agonists: our best frenemy in cancer immunotherapyQ36850457
Toll-like receptors in the brain and their potential roles in neuropathology.Q36898647
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9Q36909178
Targeting IRAK1 as a therapeutic approach for myelodysplastic syndromeQ37011627
Toll-like receptors' two-edged sword: when immunity meets apoptosis.Q37011869
Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production.Q37060644
A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphomaQ37090435
Induction of myelodysplasia by myeloid-derived suppressor cells.Q37259216
Cancer Cells Expressing Toll-like Receptors and the Tumor MicroenvironmentQ37373357
Combinations of TLR ligands: a promising approach in cancer immunotherapyQ37383587
Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsisQ37414700
Consequences of the recurrent MYD88(L265P) somatic mutation for B cell toleranceQ37630211
The TAK1-TRAF6 signalling pathwayQ37671306
Anticancer function of polyinosinic-polycytidylic acidQ37798657
Inflammatory signals regulate hematopoietic stem cellsQ37828295
Toll-Like Receptors (TLRs): The Role in Tumor ProgressionQ38014847
Pediatric myelodysplastic syndromes: they do exist!Q38171923
The mechanism of action of BCG therapy for bladder cancer--a current perspectiveQ38184849
TLR Agonists for Cancer Immunotherapy: Tipping the Balance between the Immune Stimulatory and Inhibitory EffectsQ38195599
The inflammatory microenvironment in MDS.Q38348119
Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cellsQ38507121
Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged swordQ38878794
Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemiaQ38888128
Direct Toll-like receptor-mediated stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation toward macrophagesQ39363077
Inflammation-induced up-regulation of TLR2 expression in human endothelial cells is independent of differential methylation in the TLR2 promoter CpG island.Q39504839
Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanismsQ39675197
The TLR1/2 agonist PAM(3)CSK(4) instructs commitment of human hematopoietic stem cells to a myeloid cell fateQ39819090
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergyQ40010311
Human skin endothelial cells can express all 10 TLR genes and respond to respective ligandsQ40058099
TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistanceQ40165390
Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptorsQ40289625
Toll-like receptors mediate proliferation and survival of multiple myeloma cellsQ40291993
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta inductionQ40675827
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reactionQ41149988
Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebratesQ41582148
A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia.Q42285217
G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signalingQ42787187
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.Q43845859
Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphomaQ43897803
A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.Q45976947
The history of Toll-like receptors - redefining innate immunity.Q46240771
STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.Q46493365
Upregulation of TLR2 expression on G-CSF-mobilized peripheral blood stem cells is responsible for their rapid engraftment after allogeneic hematopoietic stem cell transplantation.Q53442383
The expression of Toll-like receptors in patients with acute myeloid leukemia treated with induction chemotherapy.Q53627646
Expression and function of toll-like receptors in multiple myeloma patients: toll-like receptor ligands promote multiple myeloma cell growth and survival via activation of nuclear factor-kappaB.Q54419884
Expression and function of toll like receptors in chronic lymphocytic leukaemia cells.Q54505699
Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+ progenitor cells along the myeloid lineage.Q54575672
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)390
P577publication date2016-09-28
P1433published inFrontiers in ImmunologyQ27723748
P1476titleThe Role of Toll-Like Receptors in Hematopoietic Malignancies
P478volume7

Reverse relations

cites work (P2860)
Q94547384A Dual TLR7/TLR9 Inhibitor HJ901 Inhibits ABC-DLBCL Expressing the MyD88 L265P Mutation
Q40246794Activation of TLR7 Inhibition of Mycobacterium Tuberculosis Survival by Autophagy in RAW 264.7 Macrophages.
Q47106227Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigen-specific IgA seropositive population.
Q91341088Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NFκB signaling
Q92978283Depicting the genetic architecture of pediatric cancers through an integrative gene network approach
Q64076861Dysregulation of Cell Survival in Diffuse Large B Cell Lymphoma: Mechanisms and Therapeutic Targets
Q92977777Expression of toll-like receptors and their regulatory roles in murine cardiac telocytes
Q92127608Functional Toll-Like Receptors (TLRs) Are Expressed by a Majority of Primary Human Acute Myeloid Leukemia Cells and Inducibility of the TLR Signaling Pathway Is Associated with a More Favorable Phenotype
Q55401366Hsp90 Inhibition Reduces TLR5 Surface Expression and NF-κB Activation in Human Myeloid Leukemia THP-1 Cells.
Q47116205Inflammatory Signaling Pathways in Preleukemic and Leukemic Stem Cells
Q49875948Loss of toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS.
Q89909025Network Pharmacology-Based Investigation of the System-Level Molecular Mechanisms of the Hematopoietic Activity of Samul-Tang, a Traditional Korean Herbal Formula
Q38650702Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations
Q89776910Proliferation through activation: hemophagocytic lymphohistiocytosis in hematologic malignancy
Q37690959Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways
Q48336230RNA-binding proteins mind the GAPs.
Q48018788Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases
Q41123286Role of Type I and II Interferons in Colorectal Cancer and Melanoma.
Q64055264Yersinia pestis Exploits Early Activation of MyD88 for Growth in the Lungs during Pneumonic Plague

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