Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?

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Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis? is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1111/PIM.12166
P3181OpenCitations bibliographic resource ID796079
P932PMC publication ID4359005
P698PubMed publication ID25655311
P5875ResearchGate publication ID269286921

P50authorElizabeth D EnglishQ57061306
P2093author name stringJ P Boyle
Y Adomako-Ankomah
P2860cites workComparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategyQ21090491
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The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Q27341809
A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma VirulenceQ27670588
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiQ28476607
A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteinsQ28481222
Fatal outbreak of human toxoplasmosis along the Maroni River: epidemiological, clinical, and parasitological aspectsQ29353941
Globalization and the population structure of Toxoplasma gondiiQ30355588
Redescription of Neospora caninum and its differentiation from related coccidia.Q31084246
Redescription of Hammondia hammondi and its differentiation from Toxoplasma gondiiQ33194144
The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteinsQ33218406
ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondiiQ33274196
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.Q33591077
GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune responseQ33602978
Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulenceQ33606893
Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9.Q33648073
ROP18 is a key factor responsible for virulence difference between Toxoplasma gondii and Neospora caninumQ33753887
The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in miceQ33861156
Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondiiQ33960170
In the absence of endogenous gamma interferon, mice acutely infected with Neospora caninum succumb to a lethal immune response characterized by inactivation of peritoneal macrophagesQ33999302
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth controlQ34023014
Lytic cycle of Toxoplasma gondiiQ34023676
Strain-dependent host transcriptional responses to Toxoplasma infection are largely conserved in mammalian and avian hostsQ34056304
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.Q34121309
Infected dendritic cells facilitate systemic dissemination and transplacental passage of the obligate intracellular parasite Neospora caninum in miceQ34189342
Importance of nonenteric protozoan infections in immunocompromised people.Q34189873
Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.Q34230563
The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPasesQ34283543
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.Q34325516
Hammondia hammondi, an avirulent relative of Toxoplasma gondii, has functional orthologs of known T. gondii virulence genesQ34339536
Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondiiQ34432069
Severe acquired toxoplasmosis in immunocompetent adult patients in French Guiana.Q34438816
Dogs are definitive hosts of Neospora caninumQ34475050
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.Q34501481
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondiiQ34591236
Hammondia hammondi harbors functional orthologs of the host-modulating effectors GRA15 and ROP16 but is distinguished from Toxoplasma gondii by a unique transcriptional profileQ34592579
A history of studies that examine the interactions of Toxoplasma with its host cell: Emphasis on in vitro modelsQ34610212
Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondiiQ34697891
Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondiiQ34772368
Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinasesQ35034984
Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulenceQ35035005
Toxoplasma gondii: Infection natural congenital in cattle and an experimental inoculation of gestating cows with oocystsQ60668398
Toxoplasmosis in a calfQ66918054
Neospora caninum (Apicomplexa) in an aborted equine fetusQ68559875
Neosporosis-like abortions in a herd of dairy cattleQ69155072
A Neospora-like protozoon found in an aborted bovine placentaQ69390288
Toxoplasma gondii-induced abortion in dairy goatsQ69491150
Primary and reactivated toxoplasma infection in patients with cardiac transplants. Clinical spectrum and problems in diagnosis in a defined populationQ70261374
Spleen and lymph node cell populations, in vitro cell proliferation and interferon-gamma production during the primary immune response to Toxoplasma gondiiQ70324564
Repeat transplacental transfer of Toxoplasma gondii in dairy goatsQ70372884
Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmissionQ70415014
Abortion associated with toxoplasmosis in sheep in OregonQ70686429
Immune response of mice to ingested Toxoplasma gondii: a model of toxoplasma infection acquired by ingestionQ71276726
A survey of the incidence of Neospora caninum infection in aborted and stillborn bovine fetuses in England and WalesQ71771109
Toxoplasma gondii Comprises Three Clonal Lineages: Correlation of Parasite Genotype with Human DiseaseQ71829835
Interferon-gamma and interleukin-12 mediate protection to acute Neospora caninum infection in BALB/c miceQ73296745
Murine ileitis after intracellular parasite infection is controlled by TGF-beta-producing intraepithelial lymphocytesQ73570988
Prevalence of antibodies to Neospora caninum and Toxoplasma gondii in cattle and water buffaloes in southern VietnamQ74496093
Acute toxoplasmosis leads to lethal overproduction of Th1 cytokinesQ74601866
Prevalence of Neospora caninum and Toxoplasma gondii in sheep and dogs from Guarapuava farms, Paraná State, BrazilQ79698861
The induction of acute ileitis by a single microbial antigen of Toxoplasma gondiiQ80418731
Prevalence of anti-Toxoplasma gondii and anti-Neospora caninum antibodies in ovine from São Paulo State, BrazilQ80483248
Prevalence of anti-Toxoplasma gondii and anti-Neospora caninum antibodies in goats slaughtered in the public slaughterhouse of Patos city, Paraíba State, Northeast region of BrazilQ80812076
HUMAN TOXOPLASMOSIS: OCCURRENCE IN INFANTS AS AN ENCEPHALOMYELITIS VERIFICATION BY TRANSMISSION TO ANIMALSQ80891678
Seroprevalence of Toxoplasma gondii and Neospora caninum in dairy goats from RomaniaQ83002070
Histopathology of the reproductive system of male sheep experimentally infected with Toxoplasma gondiiQ83346950
Seroprevalence of Toxoplasma gondii and Neospora caninum infection in dairy cows in subtropical southern ChinaQ84420606
Experimental infection by Toxoplasma gondii using contaminated semen containing different doses of tachyzoites in sheepQ40363898
A Hammondia-like parasite from the European fox (Vulpes vulpes) forms biologically viable tissue cysts in cell culture.Q40659332
Experimental toxoplasmosis in calves and pregnant cows.Q40864111
Cross-immunity between Hammondia and Toxoplasma infections in mice and hamstersQ40907815
Experimental neosporosis in pregnant ewes and their offspringQ40921821
Hammondia hammondi cysts in cell culturesQ41292848
Abortions, fetal death, and stillbirths in pregnant pygmy goats inoculated with tachyzoites of Neospora caninum.Q41307483
Sexual transmission of Toxoplasma gondii in sheepQ42276185
Isolated, spontaneous Toxoplasma abortion in a young sowQ42969593
Neospora caninum (Apicomplexa) in a stillborn goatQ43208709
Isolation of Toxoplasma gondii from a Naturally Infected Beef CowQ43208804
Neospora caninum-like protozoon associated with fatal myelitis in newborn calvesQ43209417
Neospora caninum (Protozoa: apicomplexa) infections in miceQ43209672
Toxoplasma gondii-induced abortion in sheepQ43209917
Hammondia hammondi: A new coccidium of cats producing cysts in muscle of other mammalsQ43827285
Differential induction of TLR3-dependent innate immune signaling by closely related parasite speciesQ35088720
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.Q35102296
Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host responseQ35159661
Efficient genome engineering of Toxoplasma gondii using CRISPR/Cas9.Q35196266
Toxoplasma gondii effectors are master regulators of the inflammatory responseQ35434828
A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondiiQ35547974
Toxoplasma gondii targets a protein phosphatase 2C to the nuclei of infected host cells.Q35641036
A single chromosome unexpectedly links highly divergent isolates of Toxoplasma gondii.Q35652335
Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodellingQ36191387
Newly recognized fatal protozoan disease of dogsQ36453577
Role of NK cells and gamma interferon in transplacental passage of Toxoplasma gondii in a mouse model of primary infectionQ36576126
High rate of transplacental infection and transmission of Neospora caninum following experimental challenge of cattle at day 210 of gestationQ36597151
Tissue distribution of Neospora caninum in experimentally infected cattleQ36606763
Hammondia hammondi gen. nov., sp.nov., from domestic cats, a new coccidian related to Toxoplasma and SarcocystisQ36738279
Oral oocyst-induced mouse model of toxoplasmosis: effect of infection with Toxoplasma gondii strains of different genotypes, dose, and mouse strains (transgenic, out-bred, in-bred) on pathogenesis and mortalityQ36931850
Kiss and spit: the dual roles of Toxoplasma rhoptriesQ37024471
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologueQ37087502
Polymorphic secreted kinases are key virulence factors in toxoplasmosisQ37105671
Materno-fetal Toxoplasma gondii infection: critical review of available diagnostic methods.Q37119599
Severe acquired toxoplasmosis caused by wild cycle of Toxoplasma gondii, French GuianaQ37164712
A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation.Q37194952
Experimental infection with a low virulence isolate of Neospora caninum at 70 days gestation in cattle did not result in foetopathyQ37246826
Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouseQ37262073
Toxoplasma gondii, "new" genotypes and virulenceQ37278534
Differential locus expansion distinguishes Toxoplasmatinae species and closely related strains of Toxoplasma gondiiQ37631484
Toxoplasma gondii prevalence in farm animals in the United StatesQ38064203
Seroprevalence of antibodies to Neospora caninum and Toxoplasma gondii in water buffaloes (Bubalus bubalis) from EgyptQ38978806
Neospora caninum is associated with abortion in Algerian cattleQ39021601
The extent of parasite-associated necrosis in the placenta and foetal tissues of cattle following Neospora caninum infection in early and late gestation correlates with foetal death.Q39023059
Neospora caninum in cattle: experimental infection with oocysts can result in exogenous transplacental infection, but not endogenous transplacental infection in the subsequent pregnancyQ39231233
Acute phase toxoplasma abortions in sheep.Q39331566
Transplacental transmission in cattle: is Toxoplasma gondii less potent than Neospora caninum?Q39591901
Experimental Hammondia hammondi Infection in MonkeysQ39601801
A helical membrane-binding domain targets the Toxoplasma ROP2 family to the parasitophorous vacuoleQ39812575
Fatal Toxoplasma gondii Dissemination in a Heart Transplant Recipient: Description of a CaseQ40263480
Development of lesions and tissue distribution of parasite in lambs orally infected with sporulated oocysts of Toxoplasma gondii.Q40329839
Toxoplasmosis and neosporosis among beef cattle slaughtered for food in Western Thailand.Q43875260
Toxoplasma gondii in cats: fecal stages identified as coccidian oocystsQ44047126
Toxoplasma-induced abortion in dairy goats.Q44139987
Studies on the role of interleukin-12 in acute murine toxoplasmosisQ44321828
Prevalence of Toxoplasma gondii and Neospora caninum infections in sheep from Federal District, central region of BrazilQ44375480
Pathogenic characterization in mice of Neospora caninum isolates obtained from asymptomatic calvesQ44460553
Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice.Q44517620
Seroprevalence of Toxoplasma gondii and Neospora caninum infections in goats in Poland.Q44709962
Interferon-gamma: the major mediator of resistance against Toxoplasma gondiiQ45128276
Virulent strains of Toxoplasma gondii comprise a single clonal lineageQ46105888
Detection of Neospora sp. from infected bovine tissues by PCR and probe hybridizationQ46275068
Experimental vaginal infection of goats with semen contaminated with the "CPG" strain of Toxoplasma gondii.Q46326606
Oocysts of Neospora caninum, Hammondia heydorni, Toxoplasma gondii and Hammondia hammondi in faeces collected from dogs in Germany.Q46730415
Recent expansion of Toxoplasma through enhanced oral transmissionQ47411368
The pathogenesis of experimental neosporosis in pregnant sheepQ47889692
Antigenic similarity between Hammondia hammondi and Toxoplasma gondii tachyzoitesQ47913610
Molecular and biological characterization of first isolates of Hammondia hammondi from cats from EthiopiaQ48040242
Repetitive abortion in Neospora-infected ewesQ48199380
Comparison of the biological characteristics of two isolates of Neospora caninumQ48203183
Characterisation of the first Australian isolate of Neospora caninum from cattleQ48433059
Neospora caninum: high susceptibility to the parasite in C57BL/10ScCr mice.Q48454611
Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondiiQ48464908
Outbreak of central-nervous-system toxoplasmosis in western Europe and North AmericaQ48662823
Experimental infection of non-pregnant and pregnant sheep with Neospora caninumQ48665095
Occurrence of Neospora caninum and Toxoplasma gondii infections in ovine and caprine abortions.Q48703379
Neospora caninum: role for immune cytokines in host immunityQ48811296
Distribution of lesions in fetal brains following experimental infection of pregnant sheep with Toxoplasma gondiiQ48834740
Fatal congenital Neospora caninum infection in a lambQ49116433
Maternal infection with toxoplasma gondii in pregnancy and the risk of hearing loss in the offspringQ50440055
Chronic Neospora caninum infection and repeat abortion in dairy cows: a 3-year study.Q50803633
Serologic diagnosis of toxoplasmosis in experimentally infected pregnant goats and transplacentally infected kids.Q50916246
Toxoplasma gondii and Neospora caninum antibodies in sheep in the Czech Republic.Q51669441
Construction of a molecular karyotype for Toxoplasma gondiiQ54272649
Detection of Toxoplasma gondii in the reproductive system of male goatsQ54406907
Fetal death in cows experimentally infected with Neospora caninum at 110 days of gestationQ57743080
Evidence that primary infection of Charollais sheep with Toxoplasma gondii may not prevent foetal infection and abortion in subsequent lambingsQ58416874
Gerbils ( Meriones unguiculatus ) are highly susceptible to oral infection with Neospora caninum oocystsQ58708364
Mouse Model for Central Nervous System Neospora caninum InfectionsQ58708751
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectToxoplasmaQ9360606
eukaryoteQ19088
Toxoplasma gondiiQ131003
toxoplasmosisQ154878
pathogenesisQ372016
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)127-140
P577publication date2015-03-01
P1433published inParasite ImmunologyQ15751559
P1476titleSecreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?
P478volume37

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cites work (P2860)
Q91026493Annotating the 'hypothetical' in hypothetical proteins: In-silico analysis of uncharacterised proteins for the Apicomplexan parasite, Neospora caninum
Q26776334Flagellar membrane proteins in kinetoplastid parasites
Q58702723Genome Wide Identification of Mutational Hotspots in the Apicomplexan Parasite Neospora caninum and the Implications for Virulence
Q48277104Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines
Q33847295IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns
Q89516778Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum
Q26747055Recent advances in understanding apicomplexan parasites
Q37499182Vacuolar protein sorting mechanisms in apicomplexan parasites

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