ROP18 is a key factor responsible for virulence difference between Toxoplasma gondii and Neospora caninum

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ROP18 is a key factor responsible for virulence difference between Toxoplasma gondii and Neospora caninum is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...999744L
P356DOI10.1371/JOURNAL.PONE.0099744
P932PMC publication ID4057265
P698PubMed publication ID24927100
P5875ResearchGate publication ID263099155

P2093author name stringHui Wang
Jing Liu
Qun Liu
Tao Lei
Huizhu Nan
P2860cites workExpression of Toxoplasma gondii genes in the closely-related apicomplexan parasite Neospora caninum.Q53969942
Toxoplasma gondii immune mapped protein-1 (TgIMP1) is a novel vaccine candidate against toxoplasmosisQ56769278
Construction of Neospora caninum stably expressing TgSAG1 and evaluation of its protective effects against Toxoplasma gondii infection in miceQ85014576
Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategyQ21090491
Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Q22255523
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuoleQ24614550
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulenceQ24617053
Concerted action of two formins in gliding motility and host cell invasion by Toxoplasma gondiiQ27313299
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Q27341809
Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasionQ28210733
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiQ28476607
Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries.Q30328708
Redescription of Neospora caninum and its differentiation from related coccidia.Q31084246
Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and the anti-NcAMA1 antibody inhibits host cell invasion by both parasitesQ33265989
ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondiiQ33274196
A unique dual activity amino acid hydroxylase in Toxoplasma gondiiQ33416807
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.Q33591077
Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophagesQ33766719
Comparison of the major antigens of Neospora caninum and Toxoplasma gondiiQ33802271
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.Q34121309
Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.Q34157453
Toxoplasma gondii transmembrane microneme proteins and their modular designQ34316176
Proteomic analysis of rhoptry organelles reveals many novel constituents for host-parasite interactions in Toxoplasma gondiiQ34432069
Genotypes and mouse virulence of Toxoplasma gondii isolates from animals and humans in ChinaQ34545122
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondiiQ34591236
Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response.Q34757058
Toxoplasma gondii: the model apicomplexan.Q34909928
Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulenceQ35035005
Stable DNA transformation in the obligate intracellular parasite Toxoplasma gondii by complementation of tryptophan auxotrophyQ35476035
Acute virulence in mice is associated with markers on chromosome VIII in Toxoplasma gondiiQ35532044
Intracellular parasite invasion strategiesQ35741714
The secreted kinase ROP18 defends Toxoplasma's borderQ36041799
Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected hostQ36228600
Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophagesQ36228861
Newly recognized fatal protozoan disease of dogsQ36453577
Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).Q37006326
Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families.Q37034561
Polymorphic secreted kinases are key virulence factors in toxoplasmosisQ37105671
Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuoleQ39735086
Characterisation of Toxoplasma gondii engineered to express mouse interferon-gammaQ40624199
Identification and characterization of a novel Neospora caninum immune mapped protein 1.Q42639414
The expression of Toxoplasma proteins in Neospora caninum and the identification of a gene encoding a novel rhoptry proteinQ42667167
Virulent strains of Toxoplasma gondii comprise a single clonal lineageQ46105888
Recent expansion of Toxoplasma through enhanced oral transmissionQ47411368
Discrimination of Neospora caninum from Toxoplasma gondii and other apicomplexan parasites by hybridization and PCR.Q48061435
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectToxoplasma gondiiQ131003
Neospora caninumQ1431408
P304page(s)e99744
P577publication date2014-06-13
P1433published inPLOS OneQ564954
P1476titleROP18 is a key factor responsible for virulence difference between Toxoplasma gondii and Neospora caninum
P478volume9

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cites work (P2860)
Q42682333Characterization of novel microneme adhesive repeats (MAR) in Eimeria tenella
Q40369803Characterization of the Neospora caninum NcROP40 and NcROP2Fam-1 rhoptry proteins during the tachyzoite lytic cycle.
Q58702723Genome Wide Identification of Mutational Hotspots in the Apicomplexan Parasite Neospora caninum and the Implications for Virulence
Q36321820Identification and characterization of GRA6/GRA7 of Neospora caninum in MDBK cells
Q90020504NcGRA17 is an important regulator of parasitophorous vacuole morphology and pathogenicity of Neospora caninum
Q28830507Neospora caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity
Q40094125Neospora caninum ROP16 play an important role in the pathogenicity by phosphorylating host cell STAT3.
Q35573325Neospora caninum Recruits Host Cell Structures to Its Parasitophorous Vacuole and Salvages Lipids from Organelles
Q33812897New molecular tools in Neospora caninum for studying apicomplexan parasite proteins.
Q37684373Rhoptry protein 5 (ROP5) Is a Key Virulence Factor in Neospora caninum
Q28082044Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?
Q36201858T. gondii rhoptry protein ROP18 induces apoptosis of neural cells via endoplasmic reticulum stress pathway
Q40084847Toxoplasma gondii and Neospora caninum induce different host cell responses at proteome-wide phosphorylation events; a step forward for uncovering the biological differences between these closely related parasites.

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