| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | Melki R | |
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| Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death | Q28287762 | ||
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| Regulation of HSF1 function in the heat stress response: implications in aging and disease | Q28307651 | ||
| Molecular chaperones in protein folding and proteostasis | Q29547715 | ||
| Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation | Q29615640 | ||
| Neuroinflammation in Parkinson's disease: a target for neuroprotection? | Q29616300 | ||
| Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases | Q29616535 | ||
| Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders | Q29619537 | ||
| Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice | Q29620597 | ||
| Theory of protein folding: the energy landscape perspective | Q30428743 | ||
| Prion-like transmission of protein aggregates in neurodegenerative diseases | Q33544162 | ||
| Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA. | Q33557077 | ||
| Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention | Q33663970 | ||
| Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice | Q33925689 | ||
| The heat shock response: systems biology of proteotoxic stress in aging and disease | Q34257283 | ||
| Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition | Q34413909 | ||
| Pharmacological treatment of Parkinson disease: a review | Q34416640 | ||
| The channel hypothesis of Huntington's disease | Q34446587 | ||
| What drives amyloid molecules to assemble into oligomers and fibrils? | Q34494487 | ||
| Koch's postulates and infectious proteins | Q34526708 | ||
| Levodopa and the progression of Parkinson's disease | Q34553278 | ||
| In vivo demonstration that alpha-synuclein oligomers are toxic | Q34652122 | ||
| Alpha-synuclein transfers from neurons to oligodendrocytes | Q35079415 | ||
| Hsc70 protein interaction with soluble and fibrillar alpha-synuclein | Q35266716 | ||
| Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration | Q35542169 | ||
| Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis | Q35601755 | ||
| Small-molecule proteostasis regulators for protein conformational diseases | Q35683088 | ||
| Levodopa in the treatment of Parkinson's disease: current controversies | Q35889917 | ||
| Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice | Q35946149 | ||
| Trans-cellular propagation of Tau aggregation by fibrillar species | Q36003836 | ||
| Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells | Q36045483 | ||
| Fibrillar structure and charge determine the interaction of polyglutamine protein aggregates with the cell surface | Q36216005 | ||
| Heat shock response modulators as therapeutic tools for diseases of protein conformation | Q36217181 | ||
| Identification of protein interfaces between α-synuclein, the principal component of Lewy bodies in Parkinson disease, and the molecular chaperones human Hsc70 and the yeast Ssa1p. | Q36294832 | ||
| Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport | Q36374952 | ||
| Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases? | Q36648907 | ||
| Brain homogenates from human tauopathies induce tau inclusions in mouse brain | Q36915421 | ||
| Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases | Q37119983 | ||
| Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide | Q37151260 | ||
| Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity | Q37209664 | ||
| Structural and functional characterization of two alpha-synuclein strains | Q37305236 | ||
| Transmission of multiple system atrophy prions to transgenic mice | Q37353012 | ||
| Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells | Q37446544 | ||
| Neuroglia in neurodegeneration | Q37640508 | ||
| Autophagy for tissue homeostasis and neuroprotection | Q37804575 | ||
| Potential therapeutic uses of BDNF in neurological and psychiatric disorders | Q37848053 | ||
| Rottlerin and curcumin: a comparative analysis. | Q38023565 | ||
| Neural stem cell-based treatment for neurodegenerative diseases | Q38079295 | ||
| The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity | Q38118823 | ||
| Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system | Q38121352 | ||
| Differential scales of protein quality control | Q38200251 | ||
| The organisation of the cell membrane: do proteins rule lipids? | Q38210822 | ||
| Latest treatment options for Alzheimer's disease, Parkinson's disease dementia and dementia with Lewy bodies | Q38225930 | ||
| Advances in the therapy of Alzheimer's disease: targeting amyloid beta and tau and perspectives for the future | Q38299414 | ||
| Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons | Q38975954 | ||
| Toxic effects of amyloid fibrils on cell membranes: the importance of ganglioside GM1. | Q39445726 | ||
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| Propagation of tau misfolding from the outside to the inside of a cell. | Q39873721 | ||
| Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic | Q40065738 | ||
| Small molecule inhibitors of alpha-synuclein filament assembly | Q40282679 | ||
| A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis | Q41672628 | ||
| Distinct tau prion strains propagate in cells and mice and define different tauopathies | Q41904960 | ||
| Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau | Q41979763 | ||
| Cell biology. A unifying role for prions in neurodegenerative diseases | Q41997625 | ||
| Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice | Q42874098 | ||
| The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins | Q42949802 | ||
| Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells | Q44189907 | ||
| Misfolded proteins in Huntington disease fetal grafts: further evidence of cell-to-cell transfer? | Q45299924 | ||
| Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease? | Q45300712 | ||
| Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology | Q45355658 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial 4.0 International | Q34179348 |
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | brain | Q1073 |
| neurodegeneration | Q1755122 | ||
| synucleinopathy | Q2376264 | ||
| nerve tissue protein | Q6996861 | ||
| nervous system | Q9404 | ||
| Parkinson disease associated proteins | Q77946709 | ||
| proteostasis deficiency | Q54943822 | ||
| Synuclein | Q24767155 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 217-27 | |
| P577 | publication date | 2015-01-01 | |
| P1433 | published in | Journal of Parkinson's disease | Q26842319 |
| P1476 | title | Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases | |
| P478 | volume | 5 |
| Q58598324 | A Proposed Roadmap for Parkinson's Disease Proof of Concept Clinical Trials Investigating Compounds Targeting Alpha-Synuclein |
| Q47580400 | A sensitive assay reveals structural requirements for α-synuclein fibril growth. |
| Q90003697 | Ageing as a risk factor for neurodegenerative disease |
| Q55152170 | Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration. |
| Q55360734 | Anti-Parkinson Potential of Silymarin: Mechanistic Insight and Therapeutic Standing. |
| Q55307741 | Are We Ready for Detecting α-Synuclein Prone to Aggregation in Patients? The Case of "Protein-Misfolding Cyclic Amplification" and "Real-Time Quaking-Induced Conversion" as Diagnostic Tools. |
| Q57289144 | Attempt to Untangle the Prion-Like Misfolding Mechanism for Neurodegenerative Diseases |
| Q64242757 | Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity |
| Q89963829 | Cellular Senescence in Neurodegenerative Diseases |
| Q89720828 | Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs |
| Q89557172 | Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy |
| Q26770266 | Disease Transmission by Misfolded Prion-Protein Isoforms, Prion-Like Amyloids, Functional Amyloids and the Central Dogma |
| Q89839892 | Effect of Parkin on methamphetamine-induced α-synuclein degradation dysfunction in vitro and in vivo |
| Q90219888 | Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models |
| Q38852629 | How strong is the evidence that Parkinson's disease is a prion disorder? |
| Q57792069 | Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light chain amyloidosis |
| Q90115118 | Initiation and propagation of α-synuclein aggregation in the nervous system |
| Q39297100 | Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prism. |
| Q41664833 | Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein? |
| Q94544629 | Modeling Parkinson's Disease With the Alpha-Synuclein Protein |
| Q90379922 | More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change |
| Q49562668 | Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy. |
| Q39183459 | Multiple system atrophy: insights into a rare and debilitating movement disorder |
| Q48502440 | New developments in genetic rat models of Parkinson's disease. |
| Q36319286 | Parkinson disease |
| Q64814698 | Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics |
| Q38942540 | Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases |
| Q47663712 | Potential clinical utility of multiple system atrophy biomarkers |
| Q64238991 | Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network |
| Q91705222 | Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases |
| Q39022241 | Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases. |
| Q90638178 | Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson's Disease |
| Q47665674 | Prying into the Prion Hypothesis for Parkinson's Disease |
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| Q38667942 | Review: Sporadic Parkinson's disease: development and distribution of α-synuclein pathology |
| Q61443234 | Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity |
| Q58700515 | Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study |
| Q38550428 | Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies |
| Q55027741 | Tau: A Common Denominator and Therapeutic Target for Neurodegenerative Disorders. |
| Q39035488 | The Prion-Like Behavior of Assembled Tau in Transgenic Mice |
| Q39052041 | The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases |
| Q47567656 | Therapeutic approaches to target alpha-synuclein pathology |
| Q33804420 | Types and Strains: Their Essential Role in Understanding Protein Aggregation in Neurodegenerative Diseases |
| Q52431617 | p27Kip1 regulates alpha-synuclein expression. |
| Q36499643 | α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane |
| Q92332890 | α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb |
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