Natural Compounds Modulating Mitochondrial Functions

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Natural Compounds Modulating Mitochondrial Functions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2015/527209
P3181OpenCitations bibliographic resource ID4535685
P932PMC publication ID4489008
P698PubMed publication ID26167193
P5875ResearchGate publication ID280060234

P50authorSara De BiasiQ82958176
Lara GibelliniQ114404433
Andrea CossarizzaQ38804464
Marcello PintiQ41701743
Milena NasiQ38804449
P2093author name stringElena Bianchini
P2860cites workEffect of antioxidants supplementation on aging and longevityQ41890789
Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer CellsQ41976627
Inhibition sites in F1-ATPase from bovine heart mitochondria.Q42134189
Mitochondrial DNA: a proinflammatory 'enemy from within' during HIV infection?Q42183107
Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytesQ42442589
Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating actionQ42525473
Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretionQ42710215
Quercetin treatment against ischemia/reperfusion injury in rat corpus cavernosum tissue: a role on apoptosis and oxidative stress.Q42710741
Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.Q42722691
Effect of curcumin on chromium-induced oxidative damage in male reproductive systemQ42729543
Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin.Q42875767
Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cellsQ43062416
Quercetin's influence on exercise performance and muscle mitochondrial biogenesisQ43238328
Effects of turmeric (Curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks fed aflatoxinQ43244762
Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groupsQ43548576
Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidationQ43588694
Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activityQ43750878
Effect of estradiol, diethylstilbestrol, and resveratrol on F0F1-ATPase activity from mitochondrial preparations of rat heart, liver, and brainQ43807134
Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.Q43972433
Early changes in intramitochondrial cardiolipin distribution during apoptosis.Q44159078
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosisQ44189582
In vitro peroxynitrite scavenging activity of diarylheptanoids from Curcuma longaQ44442246
Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementationQ44546815
Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cellsQ44555521
Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells.Q44638649
Evaluation of the nitric oxide radical scavenging activity of manganese complexes of curcumin and its derivativeQ44752669
Curcumin modulates free radical quenching in myocardial ischaemia in ratsQ44941078
Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL.Q45231900
Curcumin and resveratrol act by different ways on NADPH oxidase activity and reactive oxygen species produced by equine neutrophils.Q46010001
The flavonoid quercetin induces changes in mitochondrial permeability by inhibiting adenine nucleotide translocaseQ46083880
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoidQ46091889
Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generationQ46107742
Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated miceQ46335487
Quercetin inhibits lymphocyte activation and proliferation without inducing apoptosis in peripheral mononuclear cellsQ46387103
The interaction of flavonoids with mitochondria: effects on energetic processes.Q46445573
Antioxidant and radical scavenging properties of curcuminQ46545266
Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cellsQ46794275
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunctionQ46865473
Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosisQ47630326
Effects of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particlesQ47836328
Resveratrol increases antioxidant defenses and decreases proinflammatory cytokines in hippocampal astrocyte cultures from newborn, adult and aged Wistar rats.Q50480327
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.Q50711998
Curcumin prevents cerebral ischemia reperfusion injury via increase of mitochondrial biogenesis.Q51727127
Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa.Q53337206
Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression.Q53407584
Mitochondrial modifications during rat thymocyte apoptosis: a study at the single cell level.Q54023925
Strong inhibitory effects of curcumin and its demethoxy analog on Escherichia coli ATP synthase F1 sector.Q54285707
A unique mechanism of curcumin inhibition on F1 ATPase.Q54321507
Curcumin maintains cardiac and mitochondrial function in chronic kidney diseaseQ61192701
Curcumin prevents Cr(VI)-induced renal oxidant damage by a mitochondrial pathwayQ61192750
Curcumin Protects from Cardiac Reperfusion Damage by Attenuation of Oxidant Stress and Mitochondrial DysfunctionQ61192758
Changes in the xanthine dehydrogenase/xanthine oxidase ratio in the rat kidney subjected to ischemia-reperfusion stress: preventive effect of some flavonoidsQ67978197
Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-transferase in isolated rat liver nucleiQ71148341
Dietary flavonoids: intake, health effects and bioavailabilityQ73132209
Prooxidant activity of flavonoids: copper-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNAQ73294746
Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal productQ77799982
Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancerQ78109160
The interaction of energy and electron transfer reactions in mitochondria. I. General properties and nature of the products of succinate-linked reduction of pyridine nucleotideQ78814333
The effect of flavonoids on rat heart mitochondrial functionQ79732380
Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: ortho-methoxy groups are essential to enhance heme oxygenase activity and protectionQ80213574
Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetinQ80225202
Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged ratsQ80837041
Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicityQ84627293
The effects of age and resveratrol on the hypoxic preconditioning protection against hypoxia-reperfusion injury: studies in rat hearts and human cardiomyocytesQ86830476
Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responsesQ23921756
Cytoplasmic ribosomal protein S3 (rpS3) plays a pivotal role in mitochondrial DNA damage surveillanceQ24314596
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive elementQ24529933
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1Q24633063
Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cellsQ24793084
Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondriaQ26996150
Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenolsQ27647277
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanQ28203572
Resveratrol is not a direct activator of SIRT1 enzyme activityQ28261917
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alphaQ28274682
Intracellular ROS protection efficiency and free radical-scavenging activity of curcuminQ28477422
Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluationQ28534558
Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of agingQ28582783
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicineQ29547303
Mitochondrial membrane permeabilization in cell deathQ29547425
Binding of phytopolyphenol piceatannol disrupts β/γ subunit interactions and rate-limiting step of steady-state rotational catalysis in Escherichia coli F1-ATPaseQ30418606
Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians.Q33181596
Mitochondrial neurogastrointestinal encephalomyopathy: evidence of mitochondrial DNA depletion in the small intestineQ33236131
Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cellsQ33294174
Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometryQ33305815
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivoQ33417863
Regulation of survivin and Bcl-2 in HepG2 cell apoptosis induced by quercetinQ33485285
Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians.Q33657322
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrolQ33688533
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.Q33994850
Targeting mitochondria for cancer therapyQ34115304
The combination of oral quercetin supplementation and exercise prevents brain mitochondrial biogenesisQ34232723
Oxidative damage and aging: spotlight on mitochondriaQ34498676
Resveratrol attenuates ischemia/reperfusion injury in neonatal cardiomyocytes and its underlying mechanismQ34531697
Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathwaysQ39119642
Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesisQ39208622
Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen.Q39357545
Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death.Q39589256
Calpain and caspase orchestrated death signal to accomplish apoptosis induced by resveratrol and its novel analog hydroxystilbene-1 [correction of hydroxstilbene-1] in cancer cellsQ39702409
Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathwayQ39750640
Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cellsQ39799455
Uncoupling of oxidative phosphorylation by curcumin: implication of its cellular mechanism of actionQ39806743
Curcumin derivatives: molecular basis of their anti-cancer activity.Q39828576
Curcumin blocks brain tumor formationQ39860791
Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell linesQ39999539
Resistance of mtDNA-depleted cells to apoptosisQ40008780
Early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targetsQ40008951
Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancerQ40082338
Resveratrol-induced mitochondrial dysfunction and apoptosis are associated with Ca2+ and mCICR-mediated MPT activation in HepG2 cellsQ40151897
Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).Q40216907
Curcumin activated both receptor-mediated and mitochondria-mediated proteolytic pathways for apoptosis in human glioblastoma T98G cellsQ40236946
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activityQ40291546
Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cellsQ40304821
Essential requirement of reduced glutathione (GSH) for the anti-oxidant effect of the flavonoid quercetinQ40349362
Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosisQ40352598
Curcumin inhibits ROS formation and apoptosis in methylglyoxal-treated human hepatoma G2 cellsQ40407447
Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosisQ40505601
Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosisQ40594629
Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrolQ40598265
Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway.Q40602802
Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cellsQ40615972
Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax inductionQ40750009
Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapseQ40763086
Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell linesQ41107071
Exercise, but not quercetin, ameliorates inflammation, mitochondrial biogenesis, and lipid metabolism in skeletal muscle after strenuous exercise by high-fat diet miceQ34563494
Resveratrol increases vascular oxidative stress resistanceQ34573984
Neuroprotective role of nanoencapsulated quercetin in combating ischemia-reperfusion induced neuronal damage in young and aged ratsQ34688621
Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life spanQ34820212
Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicalsQ35042398
The protective effect of resveratrols on ischaemia-reperfusion injuries of rat hearts is correlated with antioxidant efficacy.Q35044291
Anticancer potential of curcumin: preclinical and clinical studies.Q35101413
Quercetin and cancer chemopreventionQ35106541
Skin resistance to oxidative stress induced by resveratrol: from Nrf2 activation to GSH biosynthesisQ35468595
Senescence, immortalization, and apoptosis. An intriguing relationshipQ35659514
Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cellsQ35679218
Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis.Q35737599
Mitochondria in health and disease: perspectives on a new mitochondrial biologyQ35859318
Mitochondria, oxidative DNA damage, and agingQ36269768
Anti-HIV drugs and the mitochondriaQ36510285
Resveratrol enhances exercise training responses in rats selectively bred for high running performanceQ36988868
Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signalingQ37060629
Curcumin pretreatment prevents potassium dichromate-induced hepatotoxicity, oxidative stress, decreased respiratory complex I activity, and membrane permeability transition pore openingQ37061933
AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetinQ37184785
Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cellsQ37222677
Quercetin induces mitochondrial biogenesis through activation of HO-1 in HepG2 cellsQ37323475
Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progressionQ37330137
Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cellsQ37430857
Resveratrol attenuates exercise-induced adaptive responses in rats selectively bred for low running performance.Q37651683
Flavonoid-induced glutathione depletion: potential implications for cancer treatmentQ37698424
Regulation of SIRT1 in cellular functions: role of polyphenolsQ37745178
Modulation of apoptosis by natural products for cancer therapyQ37756691
Mitochondrial ROS generation and its regulation: mechanisms involved in H(2)O(2) signalingQ37774660
Mitochondrial liaisons of p53.Q37780205
Mitochondrial control of cellular life, stress, and deathQ38052070
Mitochondria: master regulators of danger signallingQ38061862
The Nrf2 regulatory network provides an interface between redox and intermediary metabolismQ38197467
Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cellsQ38332714
Resveratrol supplementation: Where are we now and where should we go?Q38334249
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)527209
P577publication date2015-01-01
P1433published inEvidence-based Complementary and Alternative MedicineQ5418319
P1476titleNatural Compounds Modulating Mitochondrial Functions
P478volume2015

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